Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chu C. Chua"'
Publikováno v:
Brain Research. 1355:189-194
Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection. In this study, we examined the protective effects of an apoptosis inhibi
Autor:
Balvin H.L. Chua, Xingshun Xu, Chun-Feng Liu, Min Zhang, Chu C. Chua, Ronald C. Hamdy, Deqin Geng
Publikováno v:
Brain Research. 1343:206-212
Oxidative cell death contributes to neuronal cell death in many neurological diseases such as stroke, brain trauma, and Alzheimer's disease. In this study, we explored the involvement of poly(ADP-ribose)-polymerase (PARP) in oxidative stress-induced
Autor:
Zhongyi Chen, Ye-Shih Ho, Kao-Wei Chua, Chu C. Chua, Ronald C. Hamdy, Balvin H.L. Chua, Jinping Gao
Publikováno v:
Journal of Pineal Research. 46:235-241
Free-radical generation is one of the primary causes of myocardial ischemia/reperfusion (I/R) injury. Melatonin is an efficient free-radical scavenger and induces the expression of antioxidant enzymes. We have previously shown that melatonin can prev
Publikováno v:
Circulation. 116
Psychological and physical stressors are a major health problem in our society. The effect of chronic stress on myocardial function has not been assessed. Our hypothesis is that chronic stress induces cardiac dysfunction and that its effect is mediat
Publikováno v:
Stroke. 37(10)
Background and Purpose— Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on
Autor:
Balvin H.L. Chua, Zhongyi Chen, Cathy Landy, Jinping Gao, Ronald C. Hamdy, Chu C. Chua, Xuwan Liu
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 286(3)
The present experiments were designed to evaluate the effects of pifithrin-alpha (PFT-alpha), which is a p53 inhibitor, on doxorubicin (DOX)-induced apoptosis and cardiac injury. Administration of DOX (22.5 mg/kg ip) in mice upregulated the mRNA leve