Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Chu Biao Xue"'
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Supplemental Tables 1 & 2 Supplemental Figure Legends Supplemental Figures 1 - 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cd1caeb5c5e06cfd8b05f86b576b1
https://doi.org/10.1158/1078-0432.22475952
https://doi.org/10.1158/1078-0432.22475952
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Purpose:Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67622e0fbfefceb9ea9cf87738b999fe
https://doi.org/10.1158/1078-0432.c.6529230.v1
https://doi.org/10.1158/1078-0432.c.6529230.v1
Autor:
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Kathy Wang, Maryanne Covington, Cindy Marando, Kevin Bowman, Jason Boer, Krista Burke, Richard Wynn, Alex Margulis, Gary W Reuther, Que T Lambert, Valerie Dostalik Roman, Ke Zhang, Hao Feng, Chu-Biao Xue, Sharon Diamond, Greg Hollis, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Kris Vaddi, Peggy Scherle
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199108 (2018)
The Proviral Integration site of Moloney murine leukemia virus (PIM) serine/threonine protein kinases are overexpressed in many hematologic and solid tumor malignancies and play central roles in intracellular signaling networks important in tumorigen
Externí odkaz:
https://doaj.org/article/171a9a5db0614099bf5185681e8619f9
Autor:
Reid Huber, Maryanne Covington, Xin He, Paul Waeltz, Valerie Dostalik, Yanlong Li, Nina Zolotarjova, Chu-Biao Xue, Matthew C. Stubbs, Jun Li, Huiqing Liu, Peggy Scherle, Timothy Burn, Sharon Diamond, Thomas Maduskuie, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Christine Gardiner, Xuesong Mike Liu, Robert Collins, Nikoo Falahatpisheh, Andrew P. Combs, Phillip Liu, Margaret Favata, Gregory Hollis, Richard Wynn, Swamy Yeleswaram, Bruce Ruggeri, Alla Volgina, Ravi Kumar Jalluri, Pramod Thekkat, Darlise DiMatteo, Patricia Feldman, Mark Rupar, Xiaoming Wen
Publikováno v:
Clinical Cancer Research. 25:300-311
Purpose: Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0f9e6b013bb2a593a4e013aa8feee1
https://doi.org/10.1158/1078-0432.ccr-18-0098
https://doi.org/10.1158/1078-0432.ccr-18-0098
Autor:
Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (20, parsaclisib). The unique structure of 20 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb077aa93316c89804bca15aea78a20
https://pubmed.ncbi.nlm.nih.gov/31749910
https://pubmed.ncbi.nlm.nih.gov/31749910
Autor:
Sharon Diamond, Taisheng Huang, Karen Gallagher, Jun Li, Brittany Fay, Monika Scuron, Michael Peel, Robert C. Newton, Niu Shin, Ashish Juvekar, Peggy Scherle, Xin He, Julian Oliver, Robert Collins, Chu-Biao Xue, Krista Burke, Yan Zhang, Paul Smith, Wenqing Yao, Maryanne Covington, Margaret Favata, Sarala Sarah
Publikováno v:
European Journal of Pharmacology. 885:173505
Pharmacological modulation of the Janus kinase (JAK) family has achieved clinically meaningful therapeutic outcomes for the treatment of inflammatory and hematopoietic diseases. Several JAK1 selective compounds are being investigated clinically to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b303ded56282c591cd24d94685b79bfe
https://doi.org/10.1016/j.ejphar.2020.173505
https://doi.org/10.1016/j.ejphar.2020.173505
Autor:
Brian Metcalf, Reid Huber, Wenqing Yao, Taisheng Huang, Peggy Scherle, Bruce Ruggeri, Matthew C. Stubbs, Chu-Biao Xue, Xiaoming Wen
Publikováno v:
Cancer Research. 78:2938-2938
Non-small cell lung cancers (NSCLC) make up the majority of lung cancers, and are predominantly driven by aberrant kinase pathway signaling. Oncogenic mutations leading to activation of the epidermal growth factor receptor (EGFR) have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b81610e89409924fcd340023e1c04a1
https://doi.org/10.1158/1538-7445.am2018-2938
https://doi.org/10.1158/1538-7445.am2018-2938
Autor:
Jun Li, Richard Wynn, Jennifer J. Harris, Yanlong Li, Patricia Feldman, Xiaozhao Wang, Holly Koblish, Yvonne Lo, Jonathan Rios-Doria, Ke Liu, Peggy Scherle, Xuesong M. Liu, Chu-Biao Xue, Maryanne B. Covington, Zhenhai Gao, Kerri Lasky, Min Ye, Wenqing Yao, Chunhong He, Margaret F. Favata, Christina Stevens, Robert Landman, Yu Li, Yun-Long Li, Hui Wang, Yaoyu Chen
Publikováno v:
Cancer Research. 78:3759-3759
Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs), which are amplified, translocated, or over-expressed in numerous types of human cancer. These RTKs play important roles in tumor growth, survival, cell adhesion and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a779462e4043aa923c9c872ec3cff1
https://doi.org/10.1158/1538-7445.am2018-3759
https://doi.org/10.1158/1538-7445.am2018-3759
Autor:
Antony Chadderton, Peggy Scherle, Robert Collins, Bruce Ruggeri, Ashish Juvekar, Andrew P. Combs, Chu-Biao Xue, Holly Koblish, Melody Diamond, Richard Wynn, Xiaoming Wen, Sang Hyun Lee, Chunhong He, Gregory Hollis, Wenqing Yao, Liangxing Wu, Matthew C. Stubbs, Reid Huber
Publikováno v:
Cancer Research. 77:2032-2032
Combinatorial therapeutic strategies have achieved improved response rates and durability of responses in several malignancies either by selectively targeting distinct and non-overlapping oncogenic signaling pathways (e.g. PARP and phosphoinositide 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::013981e852c2387e1e6ff6164183c25b
https://doi.org/10.1158/1538-7445.am2017-2032
https://doi.org/10.1158/1538-7445.am2017-2032
Autor:
Brian Metcalf, Sharon Diamond, Taisheng Huang, Lixin Shao, Swamy Yeleswaram, D. Joseph Rogier, Greg Hollis, Michael Xia, Ke Zhang, Ganfeng Cao, Nancy Contel, Lingquan Kong, Peggy Scherle, Maryanne Covington, Tom Emm, Robert Hughes, Joseph Glenn, Robert C. Newton, Kris Vaddi, Changsheng Zheng, Lou Storace, Chu-Biao Xue, Rajan Anand, Hao Feng, Meloni David, Anlai Wang, Mei Li, Philip A. Morton, Robinson Darius J, Qi Han, Rajesh V. Devraj, Yingxin Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 2:913-918
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2a792b5ba70daa3c854d4e609b3ad5
https://doi.org/10.1021/ml200199c
https://doi.org/10.1021/ml200199c