Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Chu‐Bin Liao"'
Autor:
Chao-Yang Huang, Ying-Yung Lok, Chia-Hui Lin, Szu-Liang Lai, Yen-Yu Wu, Chih-Yung Hu, Chu-Bin Liao, Chen-Hsuan Ho, Yu-Ping Chou, Yi-Hsuan Hsu, Yu-Hsun Lo, Edward Chern
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundMonoclonal antibodies (mAbs) and their derivatives are the fastest expanding category of pharmaceuticals. Efficient screening and generation of appropriate therapeutic human antibodies are important and urgent issues in the field of medicin
Externí odkaz:
https://doaj.org/article/a4b03bee94c74cbeab7e62d27c7bfb94
Autor:
Hung-Jyun Huang, Win-Yin Wei, Shu Fu Lin, Shih-Hsien Chuang, Ying‐Shuen E. Lee, Chu-Bin Liao, Ching Yuh Chern, Jiann-Jyh Huang, Chun-Liang Lai, Ju-Ying Yang, Chao-Cheng Chiang, Yu-Hsiang Lin, Sheng-Chuan Yang, Chia-Wei Liu
Publikováno v:
Journal of the Chinese Chemical Society. 67:422-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d314c44815050554ea644ef35a43e201
https://doi.org/10.1002/jccs.201900466
https://doi.org/10.1002/jccs.201900466
Autor:
Cheng-I, Lee, Chu-Bin, Liao, Chih-Shang, Chen, Fen-Ying, Cheng, Yu-Hsuan, Chung, Yu-Chuan, Wang, Sian-Yi, Ciou, Wen-Yun, Hsueh, Tzu-Hao, Lo, Guan-Ru, Huang, Hsin-Yi, Huang, Chia-Shen, Tsai, Yu-Jung, Lu, Shih-Hsien, Chuang, Jiann-Jyh, Huang
Publikováno v:
Bioorganic chemistry. 109
This paper presents the design and synthesis of 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines of scaffold 9 as selective B-Raf/B-Raf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deff9655caf0e29378379bc113afe49e
https://pubmed.ncbi.nlm.nih.gov/33647741
https://pubmed.ncbi.nlm.nih.gov/33647741
Autor:
Tzu-Hao Lo, Yu-Hsuan Chung, Shih-Hsien Chuang, Cheng-I Lee, Jiann-Jyh Huang, Guan-Ru Huang, Chu-Bin Liao, Chia-Shen Tsai, Wen-Yun Hsueh, Hsin-Yi Huang, Fen-Ying Cheng, Yu-Chuan Wang, Sian-Yi Ciou, Chih-Shang Chen, Yu-Jung Lu
Publikováno v:
Bioorganic Chemistry. 109:104715
This paper presents the design and synthesis of 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines of scaffold 9 as selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 kinase inhibitors. Total 14 compounds of scaffold 9 having different side ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b175e830fda95836ac9c431c71785c
https://doi.org/10.1016/j.bioorg.2021.104715
https://doi.org/10.1016/j.bioorg.2021.104715
Publikováno v:
Journal of Clinical Oncology. 38:e15006-e15006
e15006 Background: Tumor-associated macrophages (TAMs) represent the major cell components of immune infiltrate in solid tumors, and it has been reported that high TAMs density is associated with poor clinical prognosis. Within the tumor microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b59c5fd9ee03b6c494b69c79547d6975
https://doi.org/10.1200/jco.2020.38.15_suppl.e15006
https://doi.org/10.1200/jco.2020.38.15_suppl.e15006
Autor:
Hung-Kai Chen, Li-Ming Lu, Chih-Lun Hsiao, Yin-Ping Wang, Chu-Bin Liao, Shao-Zheng Peng, Huey-Wen Hsiao, Jing-Yi Huang, Daw-Tsun Shih
Publikováno v:
Cancer Research. 79:343-343
We have found that tumor-associated macrophages (TAMs) isolated from metastatic tumors displayed a predominant M2 phenotype. Preclinical studies show that M2-polarized TAMs forge an immunosuppressive microenvironment at metastatic niches to facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2728a34487db39ee3911ceb8e2ce2e32
https://doi.org/10.1158/1538-7445.am2019-343
https://doi.org/10.1158/1538-7445.am2019-343
Publikováno v:
The Journal of Immunology. 202:135.19-135.19
Tumor-associated macrophages (TAMs) represent the major cell components of immune infiltrate in solid tumors, and it has been reported that high TAMs density is associated with poor clinical prognosis. Within the tumor microenvironment, TAMs rely on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc417329d4e6467c29d521ab8adeca13
https://doi.org/10.4049/jimmunol.202.supp.135.19
https://doi.org/10.4049/jimmunol.202.supp.135.19
Publikováno v:
DNA Repair. 7:751-761
The tumor suppressor p53 enhances repair of UVC-induced DNA damage. The comet-NE assay, a conventional alkaline comet assay which includes a nuclear digestion step, was used to examine the effects of p53 on the excision activity of nuclear extracts (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff58d2289c3087c20483fd6a0da9aa55
https://doi.org/10.1016/j.dnarep.2008.01.019
https://doi.org/10.1016/j.dnarep.2008.01.019
Publikováno v:
Journal of Cellular Biochemistry. 103:528-537
Tumor suppressor p53 is an essential regulator in mammalian cellular responses to DNA damage including cell cycle arrest and apoptosis. Our study with Chinese hamster ovary CHO-K1 cells indicates that when p53 expression and its transactivation capac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a43a39de3b3f22729e8f67436cb2cc
https://doi.org/10.1002/jcb.21428
https://doi.org/10.1002/jcb.21428
Publikováno v:
Photochemistry and Photobiology. 75:662-667
Exposure to UVC induces apoptosis in Chinese hamster ovary (CHO.K1) cells. While studying the underlying mechanism, we found that a variety of cell cycle inhibitors, including colcemid, hydroxyurea and mimosine, enhance the UV-induced apoptosis in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb4166bcd6924cbf1d305082d0ecad3
https://doi.org/10.1562/0031-8655(2002)0750662tuodtu2.0.co2
https://doi.org/10.1562/0031-8655(2002)0750662tuodtu2.0.co2