Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chrystelle Marie Rasamison"'
Autor:
Geoffrey Martyn Williams, Felix Spindler, Daniel Black, Philippe Wong-Kai-In, P. John Murray, Martin James Procter, Rosemary Chatfield, Lisa Sarah Bertram, Andrew Cooke, Kosuke Yasuda, Roy Turton, Paul H. Briner, Frédéric Naud, Karen Lesley Schofield, Günaj Rakipovski, Amanda Taylor, Masao Nawano, Christine Reynet, Chrystelle Marie Rasamison, Matthew Colin Thor Fyfe, Vilas K. Shah
Publikováno v:
Journal of Medicinal Chemistry. 51:4340-4345
Allosteric activators of the glucose-sensing enzyme glucokinase (GK) are currently attracting much interest as potential antidiabetic therapies because they can achieve powerful blood glucose lowering through actions in multiple organs. Here, the opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96638620f497a62ba910de15908f24ed
https://doi.org/10.1021/jm8003202
https://doi.org/10.1021/jm8003202
Publikováno v:
Organic Preparations and Procedures International. 37:194-197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b66cd1f91b1af433f2ee6bf5e21f6b
https://doi.org/10.1080/00304940509354887
https://doi.org/10.1080/00304940509354887
Autor:
Chrystelle Marie Rasamison, David J. Witter, Satomi Kurabayashi, Kosuke Yasuda, Kiichiro Ueta, Geoffrey Martyn Williams, Vilas K. Shah, Arlindo L. Castelhano, Masao Nawano, Karen Lesley Schofield, Matthew C. T. Fyfe, Rikiya Ohashi, Li Qiu, Martin James Procter, Lisa Sarah Gardner, Hanqing Dong, Yukari Kamikozawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1501-1504
The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2268f391017f4c82692898f0a17d5b0
https://doi.org/10.1016/j.bmcl.2004.12.083
https://doi.org/10.1016/j.bmcl.2004.12.083
Publikováno v:
Synlett. 2001:0629-0633
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67c00b346d06ce56c54b20b7184a53a
https://doi.org/10.1055/s-2001-13367
https://doi.org/10.1055/s-2001-13367
Publikováno v:
The Journal of Organic Chemistry. 66:7195-7198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0f7c2c514bd13132cc04e4b22e72bb
https://doi.org/10.1021/jo010152s
https://doi.org/10.1021/jo010152s
Autor:
Susan Helen Davis, Gillian A. Bottomley, Chrystelle Marie Rasamison, Phillip Clarke, Eleanor Curtis, James Charles Bell, John Keily, Patrick Eric Hanrahan, Gary Moore, Stuart Bradley, Graham Dawson, Jason Bloxham, James G. Horswill
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(6)
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc4431f48abf7265b60957ceae28bcd
https://pubmed.ncbi.nlm.nih.gov/22342626
https://pubmed.ncbi.nlm.nih.gov/22342626
Autor:
James G. Horswill, Utsav Bali, Chrystelle Marie Rasamison, Philippe Wong-Kai-In, Oscar Barba, David A. Pan, William Gattrell, Colin Peter Sambrook Smith, Graham Dawson, Amanda Taylor-Warne, Martin James Procter
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability, resulting in the discovery of a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d40bc47753cdb19fb1dfc0b1a8428e
https://pubmed.ncbi.nlm.nih.gov/22217874
https://pubmed.ncbi.nlm.nih.gov/22217874
Autor:
Christine Reynet, Graeme Griffin, Lisa Sarah Gardner, Mads Tang-Christensen, Peter S. Widdowson, Helen C. Jackson, Adam J. Babbs, Hilary A. Overton, Martin James Procter, Matthew C. T. Fyfe, Geoffery M. Williams, Chrystelle Marie Rasamison, Sheila M. Doel
Publikováno v:
Cell metabolism. 3(3)
SummaryThe endogenous lipid signaling agent oleoylethanolamide (OEA) has recently been described as a peripherally acting agent that reduces food intake and body weight gain in rat feeding models. This paper presents evidence that OEA is an endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89b59481153b230228a8411f3e90e5
https://pubmed.ncbi.nlm.nih.gov/16517404
https://pubmed.ncbi.nlm.nih.gov/16517404