Zobrazeno 1 - 10
of 767
pro vyhledávání: '"Chrystal, M."'
Autor:
Kelsey B. Bennion, Danya Liu, Abdelhameed S. Dawood, Megan M. Wyatt, Katie L. Alexander, Mohamed S. Abdel-Hakeem, Chrystal M. Paulos, Mandy L. Ford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The regulatory circuits dictating CD8+ T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that tumor-infiltrating antigen-specific PD-1+ TCF-1− CD8+ T cells express the immunosupp
Externí odkaz:
https://doaj.org/article/ac5c51a14c4148dcaf211da0aa6ca675
Autor:
Gregory B Lesinski, Chrystal M Paulos, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Megen C Wittling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background How distinct methods of host preconditioning impact the efficacy of adoptively transferred antitumor T helper cells is unknown.Methods CD4+ T cells with a transgenic T-cell receptor that recognize tyrosinase-related peptide (TRP)-1 melanom
Externí odkaz:
https://doaj.org/article/fe2e22541bba40599235ed797c618c73
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103022- (2024)
Summary: Precise integration of DNA constructs greater than 3 kb into mouse zygotes is difficult. Here, we present a protocol for large DNA transgenesis in mice using the Cas9+Bxb1 toolbox. We describe steps for choosing mouse strains with preplaced
Externí odkaz:
https://doaj.org/article/40be595ab342459aab90c3b92b524383
Autor:
Umit Keles, Julien Dubois, Kevin J. M. Le, J. Michael Tyszka, David A. Kahn, Chrystal M. Reed, Jeffrey M. Chung, Adam N. Mamelak, Ralph Adolphs, Ueli Rutishauser
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-15 (2024)
Abstract We present a multimodal dataset of intracranial recordings, fMRI, and eye tracking in 20 participants during movie watching. Recordings consist of single neurons, local field potential, and intracranial EEG activity acquired from depth elect
Externí odkaz:
https://doaj.org/article/6bfe334d1e89423fa22a175ea9192f8c
Autor:
Michael Kyzar, Jan Kamiński, Aneta Brzezicka, Chrystal M. Reed, Jeffrey M. Chung, Adam N. Mamelak, Ueli Rutishauser
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-12 (2024)
Abstract We present a dataset of 1809 single neurons recorded from the human medial temporal lobe (amygdala and hippocampus) and medial frontal lobe (anterior cingulate cortex, pre-supplementary motor area, ventral medial prefrontal cortex) across 41
Externí odkaz:
https://doaj.org/article/95cf11b37dc940019686d772ac736bfc
Autor:
Paolo A. Ascierto, Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Leisha A. Emens, Robert L. Ferris, Silvia C. Formenti, Omid Hamid, Douglas B. Johnson, Tomas Kirchhoff, Christopher A. Klebanoff, Gregory B. Lesinski, Anne Monette, Bart Neyns, Kunle Odunsi, Chrystal M. Paulos, Daniel J. Powell, Katayoun Rezvani, Brahm H. Segal, Nathan Singh, Ryan J. Sullivan, Bernard A. Fox, Igor Puzanov
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract The discovery and development of novel treatments that harness the patient’s immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. However, not all patients respond to immunotherapy, a
Externí odkaz:
https://doaj.org/article/627c0bedba0a40d4b9dd41c55b9dde62
Akademický článek
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Autor:
Domenico Galati, Serena Zanotta, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Marilena Romanelli, Ester Simeone, Lucia Festino, Francesca Sparano, Rosa Azzaro, Rosaria De Filippi, Antonio Pinto, Chrystal M. Paulos, Paolo A. Ascierto
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Nivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are resistant to PD-1 inhibition, occasionally experiencing severe off-target immune toxicity.
Externí odkaz:
https://doaj.org/article/fc778616ad9c4244b22051d8743c7e29
Autor:
Chrystal M Paulos, Megan M Wyatt, Kelsey B Bennion, Danya Liu, Abdelhameed Dawood, Mosalah S Abdel-Hakeem, Mandy L Ford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/91b6213a08394b59b81e424f942a1a9d
Autor:
Yuan Liu, Gregory B Lesinski, Chrystal M Paulos, Shishir Maithel, Brian Robinson, Megan M Wyatt, Jacklyn Hammons, Emilie AK Warren, Jessica Keilson, Guillermo O Rangel-Rivera, Caroline R Goel, Curtis J Henry, Sarah Kulkarni, Alyssa Krasinskas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/37367ff22182415cbee2fec23e4ef72b