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Autor:
George Z. Rassidakis, Sofia Tseleni-Balafouta, George Tzimas, Maria A. Kouvaraki, Konstantinos Dimas, Maria Karanikou, Efstratios Patsouris, Dimitrios Moraitis, Chryssa Liakou
Publikováno v:
Surgery. 156(6)
Mammalian target of rapamycin (mTOR) forms 2 active complexes in the cell: the rapamycin-sensitive mTOR-Raptor (mTORC1) and the rapamycin-insensitive mTOR-Rictor (mTORC2). The latter activates AKT kinase, which promotes tumor cell survival and prolif