Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chrysanthe Spais"'
Autor:
Thao Ung, Ronald Robinson, Chrysanthe Spais, Justin Schreiber, Hussein Hallak, Jean Husten, Thelma S. Angeles, Jacquelyn Lyons, Yun Liu
Publikováno v:
Bioanalysis. 13:575-585
Aim: To quantify the free form of a protein as a target-engagement biomarker in nonhuman primate serum, a Meso Scale Discovery ligand-binding assay was developed and qualified. Results: The initial assay produced an unexpected artifact when used to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ce1411ff5e30f589db719afc908cd8
https://doi.org/10.4155/bio-2020-0307
https://doi.org/10.4155/bio-2020-0307
Autor:
Sheryl L. Meyer, Jean Husten, Thelma S. Angeles, Chrysanthe Spais, Mark A. Ator, Seetha Murthy, Jennifer L. Mason, Mark S. Albom, Lisa Saville
Publikováno v:
ASSAY and Drug Development Technologies. 10:551-557
Homogeneous cellular assays can streamline product detection in the drug discovery process. One commercially available assay employing time-resolved fluorescence resonance energy transfer (TR-FRET) that detects phosphorylated products was used to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5912b44be55c0e7bad9f066e4b6cbfc
https://doi.org/10.1089/adt.2011.439
https://doi.org/10.1089/adt.2011.439
Autor:
Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e912dffb6b9ff1c34528c45a1f47ab
https://doi.org/10.1016/j.bmcl.2011.12.026
https://doi.org/10.1016/j.bmcl.2011.12.026
Autor:
Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:120-123
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63c099e60dd280977edea44193b5a96
https://doi.org/10.1016/j.bmcl.2011.11.050
https://doi.org/10.1016/j.bmcl.2011.11.050
Autor:
Ken Morii, Roberto A. Macina, Chrysanthe Spais, Harold Riethman, Dimitri G. Negorev, X.-L. Hu, Lisa A. Ruthig
Publikováno v:
Genome Research. 5:225-232
Large terminal fragments of human chromosomes 2p, 6p, 8q, 12q, and 18q were cloned using yeast artificial chromosomes (YACs). RecA-assisted restriction endonuclease (RARE) cleavage analysis of genomic DNA samples from II unrelated individuals using Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd76bae58c4b933d056800ab7d0b8a96
https://doi.org/10.1101/gr.5.3.225
https://doi.org/10.1101/gr.5.3.225
Autor:
Thelma S. Angeles, Chrysanthe Spais, Jean Husten, Jennifer L. Mason, Mark A. Ator, Mark S. Albom, Sheryl L. Meyer, Eric Prouty
Publikováno v:
Assay and drug development technologies. 10(5)
An understanding of the dynamics of drug-target interactions is important in the drug discovery process. Information related to the binding kinetics of a drug toward its target or off-target aids in determining the efficacy or toxicity of a drug. Bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8aa4196266a6e01a1fc657448f18aa
https://pubmed.ncbi.nlm.nih.gov/22690705
https://pubmed.ncbi.nlm.nih.gov/22690705
Autor:
Dmitri Negorev, Roberto A. Macina, Lisa A. Ruthig, X.-L. Hu, Harold Riethman, Chrysanthe Spais
Publikováno v:
Genomics. 22:569-578
DNA from three 1q44-derived human telomeric yeast artificial chromosome clones was analyzed using physical mapping methods. The smallest clone, yRM2004 (65 kb), corresponded exactly to the distal end of the largest clone, yRM2123 (270 kb). The third
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8fad79ab76bc120c5127e298f648e8
https://doi.org/10.1006/geno.1994.1430
https://doi.org/10.1006/geno.1994.1430
Autor:
X.-L. Hu, Lisa A. Ruthig, Dmitri Negorev, Chrysanthe Spais, Harold Riethman, Roberto A. Macina
Publikováno v:
Human Molecular Genetics. 3:1847-1853
The terminal 240 kb of a human 2q telomere region was cloned in two overlapping yeast artificial-chromosomes (YACs). This DNA contains a region of low-copy subtelomeric repeats (within 50 kb of the 2q telomere), a segment of DNA duplicated on distal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966c05a337cecd08e3090face460b78a
https://doi.org/10.1093/hmg/3.10.1847
https://doi.org/10.1093/hmg/3.10.1847
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbd67be491fa50904fc04fc20c374a04
https://pubmed.ncbi.nlm.nih.gov/22226656
https://pubmed.ncbi.nlm.nih.gov/22226656
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0ab8369735ed85da9712148db21027
https://pubmed.ncbi.nlm.nih.gov/22153937
https://pubmed.ncbi.nlm.nih.gov/22153937