Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chrysa Malosh"'
Autor:
Jerri M. Rook, Rebecca K. Senter, Rocco G. Gogliotti, Shaun R. Stauffer, Carrie K. Jones, Ayan Ghoshal, Craig W. Lindsley, José M. Bartolomé, Thomas M. Bridges, P. Jeffrey Conn, Chrysa Malosh, Rocio Zamorano, J. Scott Daniels, Colleen M. Niswender
Publikováno v:
Human Molecular Genetics. 25:1990-2004
Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic for
Autor:
José Manuel Bartolomé-Nebreda, Thomas Steckler, Susana Conde-Ceide, Colleen M. Niswender, Chrysa Malosh, María Piedrafita, Meredith J. Noetzel, Claire Mackie, Paige N. Vinson, Jerri M. Rook, Gregor James Macdonald, M. Rosa Sánchez-Casado, P. Jeffrey Conn, Shaun R. Stauffer, Carlos M. Martínez-Viturro, Hilde Lavreysen, J. Scott Daniels, Carrie K. Jones, Mark Turlington, Thomas M. Bridges, Craig W. Lindsley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5115-5120
We report the optimization of a series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) from an acyl dihydropyrazolo[1,5-a]pyrimidinone class. Investigation of exocyclic amide transpositions with this unique 5,6-bicy
Autor:
Concetta C. DiRusso, Craig W. Lindsley, Constance Ahowesso, Shaun R. Stauffer, Chrysa Malosh, Nipun Saini, David Montefusco, Jessica Chekal, Paul N. Black
Publikováno v:
Biochemical Pharmacology. 98:167-181
Chronic elevation of plasma free fatty acid (FFA) levels is commonly associated with obesity, type 2 diabetes, cardiovascular disease and some cancers. Experimental evidence indicates FFA and their metabolites contribute to disease development throug
Autor:
Susana Conde-Ceide, Craig W. Lindsley, P. Jeffrey Conn, Gregor James Macdonald, Colleen M. Niswender, J. Scott Daniels, Claire Mackie, Ya Zhou, José Manuel Bartolomé-Nebreda, Thomas Steckler, Chrysa Malosh, Carlos M. Martínez-Viturro, Jesús Alcázar, Thomas M. Bridges, Hilde Lavreysen, Shaun R. Stauffer, Carrie K. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3515-3519
This Letter describes the progress and challenges in the continued optimization of the mGlu5 positive allosteric modulator (PAM) clinical candidate VU0490551/JNJ-46778212. While many analogs addressed key areas for improvement, no one compound posses
Autor:
Jason Manka, Hilde Lavreysen, Colleen M. Niswender, Jon Jacobs, M. Luz Martín-Martín, P. Jeffrey Conn, Meredith J. Noetzel, Han Min Tong, Elizabeth J. Herman, C. David Weaver, Chrysa Malosh, J. Scott Daniels, Susana Conde-Ceide, Paige N. Vinson, Shaun R. Stauffer, Gregor James Macdonald, Claire Mackie, José Manuel Bartolomé-Nebreda, Thomas Steckler, Silvia López, Craig W. Lindsley, Carrie K. Jones, Satyawan Jadhav, Mark Turlington
Publikováno v:
Journal of Medicinal Chemistry. 57:5620-5637
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicycli
Autor:
Mark, Turlington, Chrysa, Malosh, Jon, Jacobs, Jason T, Manka, Meredith J, Noetzel, Paige N, Vinson, Satyawan, Jadhav, Elizabeth J, Herman, Hilde, Lavreysen, Claire, Mackie, José M, Bartolomé-Nebreda, Susana, Conde-Ceide, M Luz, Martín-Martín, Han Min, Tong, Silvia, López, Gregor J, MacDonald, Thomas, Steckler, J Scott, Daniels, C David, Weaver, Colleen M, Niswender, Carrie K, Jones, P Jeffrey, Conn, Craig W, Lindsley, Shaun R, Stauffer
Publikováno v:
Journal of Medicinal Chemistry
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicycli