Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chrysa Kapeni"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Joachim Hanna, Flavio Beke, Louise M. O’Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Th17 cells are critical players in the immunopathology of a range of autoimmune diseases. Here the authors implicate Hedgehog signaling in Th17 polarization and in the immunopathology of intestinal inflammation in murine models and suggest therapeuti
Externí odkaz:
https://doaj.org/article/37d7f063bb4e46ea82ad72c1a4b36302
Autor:
Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1039-1054 (2016)
MLL-AF4+ infant B cell acute lymphoblastic leukemia is characterized by an early onset and dismal survival. It initiates before birth, and very little is known about the early stages of the disease’s development. Using a conditional Mll-AF4-express
Externí odkaz:
https://doaj.org/article/6876b78c7636415d93054bf2cab58c7a
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69572 (2013)
BACKGROUND: Channelling the development of haematopoietic progenitor cells into T lymphocytes is dependent upon a series of extrinsic prompts whose temporal and spatial sequence is critical for a productive outcome. Simple models of human progenitor
Externí odkaz:
https://doaj.org/article/8a98423ca9c14245aa18b9ed2664a1ec
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J. Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E. Richardson, Brian Huntly, David R. Spring, Mikkel-Ole Skjødt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Leucine-rich repeat-containing G-protein receptor 5 (LGR5) has been characterised as a stem cell and cancer stem cell marker. Previous analyses of LGR5 transcript levels indicate high level expression discriminates malignancies such as colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b063d90b569482f715ab1d8ee2f0ad58
https://doi.org/10.1101/2022.09.01.506182
https://doi.org/10.1101/2022.09.01.506182
Autor:
Chrysa Kapeni, Leslie Nitsche, Alastair M. Kilpatrick, Nicola K. Wilson, Kankan Xia, Bahar Mirshekar-Syahkal, Vashe Chandrakanthan, Camille Malouf, John E. Pimanda, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Katrin Ottersbach
Publikováno v:
Kapeni, C, Nitsche, L, Kilpatrick, A, Wilson, N, Xia, K, Mirshekar-Syahkal, B, Pimanda, J E, Gottgens, B, Kirschner, K, Tomlinson, S R & Ottersbach, K 2022, ' p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion ', Blood, vol. 140, no. 5, pp. 464-477 . https://doi.org/10.1182/blood.2021014853
Hematopoietic stem cells (HSCs) are of major clinical importance, and finding methods for their in vitro generation is a prime research focus. We show here that the cell cycle inhibitor p57Kip2/Cdkn1c limits the number of emerging HSCs by restricting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f1fdfec50463384dc987be2d32c5ed
https://www.repository.cam.ac.uk/handle/1810/337436
https://www.repository.cam.ac.uk/handle/1810/337436
Autor:
Stephen Gadomski, Claire Fielding, Andrés García-García, Claudia Korn, Chrysa Kapeni, Sadaf Ashraf, Javier Villadiego, Raquel del Toro, Olivia Domingues, Jeremy N. Skepper, Tatiana Michel, Jacques Zimmer, Regine Sendtner, Scott Dillon, Kenneth E.S. Poole, Gill Holdsworth, Michael Sendtner, Juan J. Toledo-Aral, Cosimo De Bari, Andrew W. McCaskie, Pamela G. Robey, Simón Méndez-Ferrer
The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca12c9aaa18370fb305c74b24f72ea7b
https://api.elsevier.com/content/abstract/scopus_id/85127354047
https://api.elsevier.com/content/abstract/scopus_id/85127354047
Autor:
Leslie Nitsche, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Camille Malouf, Katrin Ottersbach, Alastair M. Kilpatrick, Nicola K. Wilson, Bahar Mirshekar-Syahkal, Chrysa Kapeni, Kankan Xia
Haematopoietic stem cells (HSCs) are of major clinical importance, and finding methods for their in vitro generation is a prime research focus. We demonstrate that the cell cycle inhibitor p57Kip2/Cdkn1c limits HSC numbers by restricting the size of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04162d8d872ab5c7b991968d72c64943
https://doi.org/10.1101/2021.09.13.459835
https://doi.org/10.1101/2021.09.13.459835
Autor:
Joachim Hanna, Flavio Beke, Louise O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Publikováno v:
Gastroenterology. 162:S-404
Autor:
Joachim Hanna, Chrysa Kapeni, Louise O’Brien, Valentina Carbonaro, Flavio Beke, Chandra Chilamakuri, Maike de la Roche
Cytotoxic CD8+T lymphocytes (CTLs) are critical to the immune response against intracellular pathogens and cancer and act by eliminating infected and malignant cells through targeted secretion of cytotoxic granules. Hedgehog (Hh) signaling has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72cc9882f941c95011159af29370ceeb
https://doi.org/10.1101/2021.03.01.433424
https://doi.org/10.1101/2021.03.01.433424