Zobrazeno 1 - 10
of 1 012
pro vyhledávání: '"Chronic lymphocytic leukemia (CLL)"'
Autor:
Alexandria P. Eiken, Elizabeth Schmitz, Erin M. Drengler, Audrey L. Smith, Sydney A. Skupa, Kabhilan Mohan, Sandeep Rana, Sarbjit Singh, Jayapal Reddy Mallareddy, Grinu Mathew, Amarnath Natarajan, Dalia El-Gamal
Publikováno v:
Hemato, Vol 5, Iss 3, Pp 321-339 (2024)
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) culminating to CLL cell survi
Externí odkaz:
https://doaj.org/article/d7db08149c6147c49528ecc49959d72e
Autor:
Sophie Peloquin, Florence Cymbalista, Martin Dreyling, Nirav N. Shah, Suzanne Murray, Romano Del Fiacco, Catherine E. Muehlenbein, Patrice Lazure
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background With recent advancements in the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), healthcare specialists may face challenges making treatment and management decisions based on latest evidence for the
Externí odkaz:
https://doaj.org/article/47933703a48b4d29b6a203e1a6617b66
Autor:
Talal Al-Assil, Shane Handelsman, Faisal Ansari, Ellen Flatley, Steven Stone, Mohammad Omaira
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundRichter’s transformation (RT) in chronic lymphocytic leukemia (CLL) is associated with poor prognosis and requires prompt modifications in patient care. CLL patients are susceptible to severe infections due to immune dysregulation induced
Externí odkaz:
https://doaj.org/article/3aa9ae132720414a9d094db9c3ec2080
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 2, Pp 264-270 (2024)
Chronic lymphocytic leukemia (CLL) is one of small B-cell lymphomas and leukemias, characterized as a clonal disease of mature B cells. The disease is remarkably heterogeneous, with the majority of patients having an indolent course, yet they are cur
Externí odkaz:
https://doaj.org/article/1415fa847e874ee39c1900ecdc742ff0
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Chronic lymphocytic leukemia (CLL) is a low-grade B-cell lymphoproliferative disorder. It is the most prevalent type of leukemia in the western countries, with a median age at diagnosis of 70 years. In 2023, it is estimated that there will be 18,740
Externí odkaz:
https://doaj.org/article/e05c1d877ff4497c9177bb2e71f01d23
Autor:
Agnieszka Goral, Marta Sledz, Aneta Manda-Handzlik, Adrianna Cieloch, Alicja Wojciechowska, Mieszko Lachota, Agnieszka Mroczek, Urszula Demkow, Radoslaw Zagozdzon, Katarzyna Matusik, Malgorzata Wachowska, Angelika Muchowicz
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2023)
Abstract Background Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfunctional immune response leading to life-threatening infections in patients. Some features typical of CLL neutro
Externí odkaz:
https://doaj.org/article/17a750dffacc4707803a8fb0469caae8
Autor:
James P. McKeown, Andrew J. Byrne, Sandra A. Bright, Clara E. Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M. McElligott, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1034 (2024)
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lym
Externí odkaz:
https://doaj.org/article/ec8f4b69512c421787aea349de4351eb
Autor:
Atefeh Khodakarami, Mahsa Afsari Kashani, Atefeh Nazer, Armin Mahmoudsalehi Kheshti, Bentolhoda Rashidi, Vahid Karpisheh, Ali Masjedi, Shiva Abolhasani, Sepideh Izadi, Rafieh Bagherifar, Seyyed Sina Hejazian, Hamed Mohammadi, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Mohammad Hojjat-Farsangi, Farhad Jadidi-Niaragh
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Targeting influential factors in resistance to chemotherapy is one way to increase the effectiveness of chemotherapeutics. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway overexpresses in chronic lymphocytic leukemi
Externí odkaz:
https://doaj.org/article/84bb4d6d12e846eaad43995f13b52c41
Autor:
Vera K. Schmid, Elias Hobeika
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL). The significant impr
Externí odkaz:
https://doaj.org/article/2bd4afbf33b645ff81da7c92582150f8
Autor:
Maria Tsagiopoulou, Ivo G. Gut
Publikováno v:
Frontiers in Genetics, Vol 14 (2024)
Chronic lymphocytic leukemia is a complex and heterogeneous hematological malignancy. The advance of high-throughput multi-omics technologies has significantly influenced chronic lymphocytic leukemia research and paved the way for precision medicine
Externí odkaz:
https://doaj.org/article/509c7242fc2f4d4599cb3d89bebdde40