Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Chronic lymphocytic leukaemia (CLL)"'
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Autor:
Qiuyi Zhang, Ying Gao, Shuchun Lin, Lynn R. Goldin, Yonghong Wang, Holly Stevenson, Daniel C. Edelman, Keith Killian, Gerald Marti, Paul S. Meltzer, Song Xiang, Neil E. Caporaso
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Background: DNA methylation aberrations are widespread among the malignant B lymphocytes of patients with chronic lymphocytic leukaemia (CLL), suggesting that DNA methylation might contribute to the pathogenesis of CLL.Aim: We aimed to explore the di
Externí odkaz:
https://doaj.org/article/90858d33f6f140b5a2f89276760261e9
Autor:
Alicia Landeira-Viñuela, Carlota Arias-Hidalgo, Pablo Juanes-Velasco, Miguel Alcoceba, Almudena Navarro-Bailón, Carlos Eduardo Pedreira, Quentin Lecrevisse, Laura Díaz-Muñoz, José Manuel Sánchez-Santos, Ángela-Patricia Hernández, Marina L. García-Vaquero, Rafael Góngora, Javier De Las Rivas, Marcos González, Alberto Orfao, Manuel Fuentes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymp
Externí odkaz:
https://doaj.org/article/62d0774abeb14b328f36f357e45ac731
Autor:
Jamie B. Oughton, Laura Collett, Dena R. Howard, Anna Hockaday, Talha Munir, Kathryn McMahon, Lucy McParland, Claire Dimbleby, David Phillips, Andy C. Rawstron, Peter Hillmen
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Achieving minimal residual disease (MRD) negativity in CLL is an independent predictor of survival even with a variety of different treatment approaches and r
Externí odkaz:
https://doaj.org/article/85a3ae6118144f27ac5415aae69c87c7
Publikováno v:
European Medical Journal, Vol 2, Iss 1, Pp 24-30 (2017)
The emergence of B cell receptor (BCR) kinase inhibitors has recently changed the treatment landscape in chronic lymphocytic leukaemia (CLL). The inhibitors that selectively target potential kinases downstream from BCR (particularly Bruton’s tyrosi
Externí odkaz:
https://doaj.org/article/bb3a68bbf5d5452da51c47fa3994402a
Akademický článek
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Akademický článek
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Autor:
Helen M. Parry, Nikhil Mirajkar, Natasha Cutmore, Jianmin Zuo, Heather Long, Marwan Kwok, Ceri Oldrieve, Chris Hudson, Tatjana Stankovic, Shankara Paneesha, Melanie Kelly, Jusnara Begum, Tina McSkeane, Guy Pratt, Paul Moss
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function. The mechanisms driving these features of e
Externí odkaz:
https://doaj.org/article/196204d8d4f9476b860bb9b6be78b48f
Autor:
Fabienne McClanahan, John Gribben
Publikováno v:
European Medical Journal Hematology, Vol 2, Iss 1, Pp 70-79 (2014)
While the standard of care for chronic lymphocytic leukaemia (CLL) leads to high overall response rates and a long progression-free survival, it can be highly toxic for many patients, particularly in the elderly who often present concurrent diseases
Externí odkaz:
https://doaj.org/article/de1353678a4f4cecb4dcb5326d61dc79
Autor:
Michele Dal Bo, Erika Tissino, Dania Benedetti, Chiara Caldana, Riccardo Bomben, Giovanni Del Poeta, Gianluca Gaidano, Francesca Maria Rossi, Antonella Zucchetto, Valter Gattei
Publikováno v:
European Medical Journal Hematology, Vol 2, Iss 1, Pp 80-87 (2014)
Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous disease characterised by the accumulation/expansion of a clonal population of neoplastic cells with the morphological appearance of small mature B lymphocytes in blood, bone marrow, an
Externí odkaz:
https://doaj.org/article/d3fd106b2ba04b5fbcf618df18ed28fc