Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Chromosomes and Gene Expression"'
Autor:
Wild, Sophia A, Cannell, Ian G, Nicholls, Ashley, Kania, Katarzyn, Bressan, Dario, Hannon, Gregory J, Sawicka, Kirsty, Bodenmiller, Bernd
Peer reviewed: True
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1043c33c69c89f7f98a9d96dc581d19
In model organisms, RNA-sequencing (RNA-seq) is frequently used to assess the effect of genetic mutations on cellular and developmental processes. Typically, animals heterozygous for a mutation are crossed to produce offspring with different genotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d226432a03d3cf0d5a7a5a3ecb88fdc
https://www.repository.cam.ac.uk/handle/1810/334534
https://www.repository.cam.ac.uk/handle/1810/334534
Publikováno v:
eLife, Vol 11 (2022)
eLife
eLife
Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as throug
Autor:
Juliane Glaser, Julian Iranzo, Maud Borensztein, Mattia Marinucci, Angelica Gualtieri, Colin Jouhanneau, Aurélie Teissandier, Carles Gaston-Massuet, Deborah Bourc'his
Publikováno v:
eLife, Vol 11 (2022)
eLife
eLife, 2022, 11, pp.e65641. ⟨10.7554/eLife.65641⟩
eLife, eLife Sciences Publication, 2022, 11, pp.e65641. ⟨10.7554/eLife.65641⟩
eLife
eLife, 2022, 11, pp.e65641. ⟨10.7554/eLife.65641⟩
eLife, eLife Sciences Publication, 2022, 11, pp.e65641. ⟨10.7554/eLife.65641⟩
Genomic imprinting refers to the mono-allelic and parent-specific expression of a subset of genes. While long recognized for their role in embryonic development, imprinted genes have recently emerged as important modulators of postnatal physiology, n
Autor:
David Mauduit, Ibrahim Ihsan Taskiran, Liesbeth Minnoye, Maxime de Waegeneer, Valerie Christiaens, Gert Hulselmans, Jonas Demeulemeester, Jasper Wouters, Stein Aerts
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Understanding how enhancers drive cell-type specificity and efficiently identifying them is essential for the development of innovative therapeutic strategies. In melanoma, the melanocytic (MEL) and the mesenchymal-like (MES) states present themselve
Autor:
Stephanie Portillo-Ledesma, William Stafford Noble, Cheng-Fu Kao, Tamar Schlick, Sarah G. Swygert, Dejun Lin, Toshio Tsukiyama, Po-Yen Lin, Dakota R Hunt
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
A longstanding hypothesis is that chromatin fiber folding mediated by interactions between nearby nucleosomes represses transcription. However, it has been difficult to determine the relationship between local chromatin fiber compaction and transcrip
Publikováno v:
eLife, vol. 10, pp. e67485
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
Differences between males and females are usually more subtle in dioecious plants than animals, but strong sexual dimorphism has evolved convergently in the South African Cape plant genus Leucadendron. Such sexual dimorphism in leaf size is expected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbef738f096fc49d8cb6a6d34c2f1b6
https://serval.unil.ch/resource/serval:BIB_796ADB75E583.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_796ADB75E583.P001/REF.pdf
Autor:
Rakesh Ramachandran, Fang Huang, Boris Matija Peterlin, Koh Fujinaga, Andrej Sali, Trang Nguyen, Ignacia Echeverria, Arthur Weiss, Hana Paculova, Daniele C. Cary
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The positive transcription elongation factor b (P-TEFb) is a critical coactivator for transcription of most cellular and viral genes, including those of HIV. While P-TEFb is regulated by 7SK snRNA in proliferating cells, P-TEFb is absent due to dimin
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Bacterial small RNAs (sRNAs) are important post-transcriptional regulators in stress responses and virulence. They can be derived from an expanding list of genomic contexts, such as processing from parental transcripts by RNase E. The role of RNase I
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally. Although microRNAs are critical regulators in mammalian cell differentiation, our understa