Zobrazeno 1 - 10
of 1 658
pro vyhledávání: '"Chromodomain"'
Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals
Autor:
Lisa Baumgartner, Jonathan J Ipsaro, Ulrich Hohmann, Dominik Handler, Alexander Schleiffer, Peter Duchek, Julius Brennecke
Publikováno v:
eLife, Vol 13 (2024)
Members of the diverse heterochromatin protein 1 (HP1) family play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3 lysine 9 (H3K9me2/3), different
Externí odkaz:
https://doaj.org/article/9e7f1a5d9827457f8ffc9152a2ef45be
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 357 (2024)
Background: Ubiquitination plays a key role in various cancers, and F-box and WD repeat domain containing 7 (FBW7) is a tumor suppressor that targets several cancer-causing proteins for ubiquitination. This paper set out to pinpoint the role of FBW7
Externí odkaz:
https://doaj.org/article/62d4642d124147649e358152418d8a27
Publikováno v:
Cells, Vol 13, Iss 10, p 851 (2024)
Spermatogenesis is a highly regulated process dependent on androgen receptor (AR) signaling in Sertoli cells. However, the pathogenic mechanisms of spermatogenic failure, by which loss of AR impairs downstream target genes to affect Sertoli cell func
Externí odkaz:
https://doaj.org/article/7e7b22474f5e409b9ce331f29f42101e
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced ovarian cancer is known for its poor prognosis due to extensive metastasis. Epigenetic alterations contribut
Externí odkaz:
https://doaj.org/article/9948a8f1d4ba407ba52218f3aa79e55c
Autor:
Andrea Cerase, Philip Avner
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100114- (2023)
The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with CHD8 mutations share common symptoms such as autistic behaviour, cognitive impairment, s
Externí odkaz:
https://doaj.org/article/ecaf1beaaa3045cc96c08091981cc9fa
Autor:
Zhao‐Wei Sun, Jarod M. Waybright, Serap Beldar, Lu Chen, Caroline A. Foley, Jacqueline L. Norris‐Drouin, Tian‐Jie Lyu, Aiping Dong, Jinrong Min, Yu‐Pu Wang, Lindsey I. James, Yun Wang
Publikováno v:
Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)
Abstract Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation remains elusive. Here it is reported that the epigenetic factor chromodomain Y‐l
Externí odkaz:
https://doaj.org/article/74310b4f2fb44ee3ab4ad07b520c84da
Akademický článek
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Autor:
Miaomiao Jia, Xueqin Zou, Shuying Yin, Weihong Tian, Yangjing Zhao, Hui Wang, Guoying Xu, Weili Cai, Qixiang Shao
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 7, Pp n/a-n/a (2022)
Abstract Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin a
Externí odkaz:
https://doaj.org/article/0cfc99868da84ad6b33db27928df5488
Autor:
Rinko Nakamura, Jun-ichi Nakayama
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 593 (2023)
Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the loca
Externí odkaz:
https://doaj.org/article/793db30d2855470e8989ae94acdd41e0
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Directed evolution is a widely-used engineering strategy for improving the stabilities or biochemical functions of proteins by repeated rounds of mutation and selection. A protein of interest is selected as the template and expressed on a molecular d
Externí odkaz:
https://doaj.org/article/cd55379257504de7b8b77480da8f7d82