Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Chromatin folding"'
Autor:
Mattia Conte, Alex Abraham, Andrea Esposito, Liyan Yang, Johan H. Gibcus, Krishna M. Parsi, Francesca Vercellone, Andrea Fontana, Florinda Di Pierno, Job Dekker, Mario Nicodemi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10215 (2024)
Here, we employ polymer physics models of chromatin to investigate the 3D folding of a 2 Mb wide genomic region encompassing the human LTN1 gene, a crucial DNA locus involved in key cellular functions. Through extensive Molecular Dynamics simulations
Externí odkaz:
https://doaj.org/article/12b7afbfa5414339ab25029ae08dae88
Autor:
Xingcheng Lin, Bin Zhang
Publikováno v:
eLife, Vol 12 (2024)
Molecular mechanisms that dictate chromatin organization in vivo are under active investigation, and the extent to which intrinsic interactions contribute to this process remains debatable. A central quantity for evaluating their contribution is the
Externí odkaz:
https://doaj.org/article/191e63794fe547bf95ad4f31e80d6527
Akademický článek
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Autor:
Kaustav Sengupta, Michał Denkiewicz, Mateusz Chiliński, Teresa Szczepińska, Ayatullah Faruk Mollah, Sevastianos Korsak, Raissa D'Souza, Yijun Ruan, Dariusz Plewczynski
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3591-3603 (2022)
The 2 m-long human DNA is tightly intertwined into the cell nucleus of the size of 10 μm. The DNA packing is explained by folding of chromatin fiber. This folding leads to the formation of such hierarchical structures as: chromosomal territories, co
Externí odkaz:
https://doaj.org/article/399317da093047909f0868a5f640a18a
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs has been shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances in an im
Externí odkaz:
https://doaj.org/article/80d1bcada4eb43aa81375ace6e1ae83c
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions thro
Externí odkaz:
https://doaj.org/article/a6fa8998948642d7b75363cb20dd92f4
Autor:
Konstantinos Sofiadis, Natasa Josipovic, Milos Nikolic, Yulia Kargapolova, Nadine Übelmesser, Vassiliki Varamogianni‐Mamatsi, Anne Zirkel, Ioanna Papadionysiou, Gary Loughran, James Keane, Audrey Michel, Eduardo G Gusmao, Christian Becker, Janine Altmüller, Theodore Georgomanolis, Athanasia Mizi, Argyris Papantonis
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-17 (2021)
Abstract Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This is perturbed once cells enter senescence and the highly abundant HMGB1 protein is depleted from n
Externí odkaz:
https://doaj.org/article/1c45f529d5074d11a54d216e9bc18458
Autor:
Alexandre Heurteau, Charlène Perrois, David Depierre, Olivier Fosseprez, Jonathan Humbert, Stéphane Schaak, Olivier Cuvier
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs are often flanked by chromatin insulators and transcription units that may participate in such demarcation
Externí odkaz:
https://doaj.org/article/77ef49985b184478ac739feecf921ef0
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Chromatin interactions are important for gene regulation and cellular specialization. Emerging evidence suggests many-body spatial interactions play important roles in condensing super-enhancer regions into a cohesive transcriptional apparat
Externí odkaz:
https://doaj.org/article/fc813635d0a04bbfb27cc15186788013
Autor:
Amir N. Zakirov, Sophie Sosnovskaya, Ekaterina D. Ryumina, Ekaterina Kharybina, Olga S. Strelkova, Oxana A. Zhironkina, Sergei A. Golyshev, Andrey Moiseenko, Igor I. Kireev
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development. Modern ideas about the spatial organization of the
Externí odkaz:
https://doaj.org/article/944fb6259d534d6cbb80cc13a111d052