Zobrazeno 1 - 10
of 3 022
pro vyhledávání: '"Chromatin accessibility"'
Autor:
Sheng Liu, Xiaona Chu, Jill L. Reiter, Xuhong Yu, Fang Fang, Patrick McGuire, Hongyu Gao, Yunlong Liu, Jun Wan, Yue Wang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that are under investigation for use in clinical trials because they are capable of self-renewal and differentiating into different cell types under defined conditions. None
Externí odkaz:
https://doaj.org/article/6b8dc3d28c0a48908c4edd90c47ea52a
Autor:
Mingkun Huang, Yufang Hu, Ling Zhang, Hua Yang, Chen Feng, Chunhong Jiang, Ning Xie, Difa Liu, Shilin Chen, Jihua Wang, Wei Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4179-4182 (2024)
Externí odkaz:
https://doaj.org/article/8dda9583c8cc4c6988220deb0425e27b
Autor:
Olivier B. Poirion, Wulin Zuo, Catrina Spruce, Candice N. Baker, Sandra L. Daigle, Ashley Olson, Daniel A. Skelly, Elissa J. Chesler, Christopher L. Baker, Brian S. White
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)
Abstract Enhlink is a computational tool for scATAC-seq data analysis, facilitating precise interrogation of enhancer function at the single-cell level. It employs an ensemble approach incorporating technical and biological covariates to infer condit
Externí odkaz:
https://doaj.org/article/d0958acda13f4ce2a7cfa49c1a75dbc4
Publikováno v:
BioMedInformatics, Vol 4, Iss 3, Pp 1822-1834 (2024)
Background: Improved technologies for chromatin accessibility sequencing such as ATAC-seq have increased our understanding of gene regulation mechanisms, particularly in disease conditions such as cancer. Methods: This study introduces a computationa
Externí odkaz:
https://doaj.org/article/7d88edf90f47413baa49811187c629b3
Autor:
Eleftheria Vasilaki, Yu Bai, Mohamad Moustafa Ali, Anders Sundqvist, Aristidis Moustakas, Carl-Henrik Heldin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background p63 is a transcription factor with intrinsic pioneer factor activity and pleiotropic functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative action of canonical, SMAD, and non-canonical, MAP-kinas
Externí odkaz:
https://doaj.org/article/c69b2398770746ad995d89ef0e1932d9
Autor:
Pooja Kathail, Richard W. Shuai, Ryan Chung, Chun Jimmie Ye, Gabriel B. Loeb, Nilah M. Ioannidis
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background A number of deep learning models have been developed to predict epigenetic features such as chromatin accessibility from DNA sequence. Model evaluations commonly report performance genome-wide; however, cis regulatory elements (CR
Externí odkaz:
https://doaj.org/article/da295330cb0b4f5faec4822e64e910e6
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Presbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects of aging on an individual's auditory capabilities. Given the limited understanding of epigenetic mechanisms
Externí odkaz:
https://doaj.org/article/12bf5a9dd83945419c31d50a7b145a58
Autor:
Chunpeng Liu, Na Ao, Yuwen Liang, Tingting Ma, Qishan Wang, Zhen Wang, Fen Wu, Zhenyang Zhang, Yifei Fang, Minghui Wang, Yuchun Pan, Jing Fu
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundCis-regulatory elements (CREs) are regions of DNA that regulate the expression of nearby genes. Changes in these elements can lead to phenotypic variations and adaptations in different populations. However, the regulatory dynamics underlyin
Externí odkaz:
https://doaj.org/article/94013f90139b403ca6c99dc7974987fc
Autor:
Alexandre A. S. F. Raposo, Pedro Rosmaninho, Susana L. Silva, Susana Paço, Maria E. Brazão, Ana Godinho-Santos, Yumie Tokunaga-Mizoro, Helena Nunes-Cabaço, Ana Serra-Caetano, Afonso R. M. Almeida, Ana E. Sousa
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Computational strategies to extract meaningful biological information from multiomics data are in great demand for effective clinical use, particularly in complex immune-mediated disorders. Regulatory T cells (Tregs) are essential for immune homeosta
Externí odkaz:
https://doaj.org/article/203ee27125d94642a450cdd9684a07fc
Publikováno v:
eLife, Vol 13 (2024)
Assay for Transposase-Accessible Chromatin sequencing (ATAC-Seq) is a widely used technique to explore gene regulatory mechanisms. For most ATAC-Seq data from healthy and diseased tissues such as tumors, chromatin accessibility measurement represents
Externí odkaz:
https://doaj.org/article/9712827c651948438aa338f2d4dd65f8