DNA and molecular genetics, chromosomes, genes and its functions and chromatin Chemistry department

Autor: Tuleab, Shakir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c072a8aa9abe38f61a89bbf0e2649f9d

Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer

Autor: Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, Vol. 12, No 1 (2021) P. 7235

Developmental genes are frequently controlled by multiple enhancers sharing similar specificities. As a result, deletions of such regulatory elements have often failed to reveal their full function. Here, we use the Pitx1 testbed locus to characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b5a53a17c83d09b92f2147f4291ae1
http://europepmc.org/articles/PMC8668926

Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies

Autor: Marjon J.A.M. Verstegen, Jeroen de Ridder, Ivo Renkens, Carlo Vermeulen, Wigard P. Kloosterman, Wouter de Laat, Britta A M Bouwman, Roy Straver, Peter H.L. Krijger, Christian Valdes-Quezada, Geert Geeven, Amin Allahyar

Publikováno v: Nature Protocols, 15(2), 364-397. Nature Publishing Group
Nature Protocols, 15(2), 364. Nature Publishing Group

We present the experimental protocol and data analysis toolbox for multi-contact 4C (MC-4C), a new proximity ligation method tailored to study the higher-order chromatin contact patterns of selected genomic sites. Conventional chromatin conformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e3fdcee30fb37bdcefb214e2021ae2
https://pure.knaw.nl/portal/en/publications/28abd704-3741-4ef3-9d0d-4a1562c34cee

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Autor: Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt Marie, Weinhold, Niels, Kimber, Scott, van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C., Li, Ni, Orlando, Giulia, Law, Philip J., Ali, Mina, Chen, Bowang, Mitchell, Jonathan S., Gudbjartsson, Daniel F., Kuiper, Rowan, Stephens, Owen W., Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R., Einsele, Hermann, Gregory, Walter A., Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H., Jöckel, Karl Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y., Mellqvist, Ulf Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, ZSofia S., Muir, Kenneth, Pashayan, Nora, Nickel, Jolanta, Nöthen, Markus M., Rafnar, Thorunn, Ross, Fiona M., da Silva Filho, Miguel Inacio, Townsend, Paul A.

Publikováno v: Went, M, Sud, A, Försti, A, Halvarsson, B-M, Weinhold, N, Kimber, S, van Duin, M, Thorleifsson, G, Holroyd, A, Johnson, D C, Li, N, Orlando, G, Law, P J, Ali, M, Chen, B, Mitchell, J S, Gudbjartsson, D F, Kuiper, R, Stephens, O W, Bertsch, U, Broderick, P, Campo, C, Bandapalli, O R, Einsele, H, Gregory, W A, Gullberg, U, Hillengass, J, Hoffmann, P, Jackson, G H, Jöckel, K-H, Johnsson, E, Kristinsson, S Y, Mellqvist, U-H, Nahi, H, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Swerdlow, A, Eeles, R A, Kote-Jarai, ZS, Muir, K, Pashayan, N, Nickel, J, Nöthen, M M, Rafnar, T, Thomsen, H, The PRACTICAL Consortium, Andersen, N F & Sørensen, K D 2018, ' Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 9, no. 1, 3707, pp. 3707 . https://doi.org/10.1038/s41467-018-04989-w
Went, M, Sud, A, Försti, A, Halvarsson, B M, Weinhold, N, Kimber, S, van Duin, M, Thorleifsson, G, Holroyd, A, Johnson, D C, Li, N, Orlando, G, Law, P J, Ali, M, Chen, B, Mitchell, J S, Gudbjartsson, D F, Kuiper, R, Stephens, O W, Bertsch, U, Broderick, P, Campo, C, Bandapalli, O R, Einsele, H, Gregory, W A, Gullberg, U, Hillengass, J, Hoffmann, P, Jackson, G H, Jöckel, K H, Johnsson, E, Kristinsson, S Y, Mellqvist, U H, Nahi, H, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Swerdlow, A, Eeles, R A, Kote-Jarai, ZS S, Muir, K, Pashayan, N, Nickel, J, Nöthen, M M, Vangsted, A, Andersen, N F, Nilsson, B, Nordestgaard, B G & The Practical Consortium 2018, ' Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 9, 3707 . https://doi.org/10.1038/s41467-018-04989-w

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bbac94bc5a60222b42fdefd033e74ed3
https://pure.au.dk/portal/da/publications/identification-of-multiple-risk-loci-and-regulatory-mechanisms-influencing-susceptibility-to-multiple-myeloma(e9249fc9-95ae-4bb0-abf9-491eb11b5c2e).html

Modulation of protein-interaction states through the cell cycle

Autor: Xavier Bisteau, Nayana Prabhu, Wendi Sun, Philipp Kaldis, Radoslaw M. Sobota, Tianyun Zhao, Yan Ting Lim, Lingyun Dai, Pär Nordlund

Publikováno v: Cell, 173 (6

Global profiling of protein expression through the cell cycle has revealed subsets of periodically expressed proteins. However, expression levels alone only give a partial view of the biochemical processes determining cellular events. Using a proteom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea861b078f9adef495a96b98a5d6d9a
https://hdl.handle.net/10356/90305