Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christy M. Hoffmann"'
Autor:
Kenji Kamimoto, Mohd Tayyab Adil, Kunal Jindal, Christy M. Hoffmann, Wenjun Kong, Xue Yang, Samantha A. Morris
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 97-112 (2023)
Summary: In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity. We previously developed CellOracle, a computational method to infer GRNs from single-cell transcr
Externí odkaz:
https://doaj.org/article/36245da6adcd4d28ba8dbd971ef7232b
Autor:
Kenji Kamimoto, Blerta Stringa, Christy M. Hoffmann, Kunal Jindal, Lilianna Solnica-Krezel, Samantha A. Morris
Publikováno v:
Nature. 614:742-751
Cell identity is governed by the complex regulation of gene expression, represented as gene-regulatory networks1. Here we use gene-regulatory networks inferred from single-cell multi-omics data to perform in silico transcription factor perturbations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07327241414cd8abcf92c8ba888d5d4a
https://doi.org/10.1038/s41586-022-05688-9
https://doi.org/10.1038/s41586-022-05688-9
Autor:
Ryan A. Martin, Shamus P. Keeler, Kangyun Wu, William J. Shearon, Devin Patel, Jiajia Li, My Hoang, Christy M. Hoffmann, Michael E. Hughes, Michael J. Holtzman
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology.
Chronic lung disease is often accompanied by disabling extrapulmonary symptoms, notably skeletal muscle dysfunction and atrophy. Moreover, the severity of respiratory symptoms correlates with decreased muscle mass and in turn lowered physical activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864ca22b9181944f84f2b21657b6293c
https://doi.org/10.1152/ajplung.00338.2022
https://doi.org/10.1152/ajplung.00338.2022
Autor:
Ryan A. Martin, Shamus P. Keeler, Kangyun Wu, William J. Shearon, Devin Patel, My Hoang, Christy M. Hoffmann, Michael E. Hughes, Michael J. Holtzman
Publikováno v:
bioRxiv : the preprint server for biology.
Chronic lung disease is often accompanied by disabling extrapulmonary symptoms, notably skeletal muscle dysfunction and atrophy. Moreover, the severity of respiratory symptoms correlates with decreased muscle mass and in turn lowered physical activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f8bdee0e49ad28b50ed199e6e4c348
https://pubmed.ncbi.nlm.nih.gov/36238722
https://pubmed.ncbi.nlm.nih.gov/36238722
Autor:
Kenji Kamimoto, Mohd Tayyab Adil, Kunal Jindal, Christy M. Hoffmann, Wenjun Kong, Xue Yang, Samantha A. Morris
SummaryIn direct lineage reprogramming, transcription factor (TF) overexpression reconfigures Gene Regulatory Networks (GRNs) to convert cell identities between fully differentiated cell types. We previously developed CellOracle, a computational pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f43b8f48de045bcb21df4529d0bc2f
https://doi.org/10.1101/2022.07.01.497374
https://doi.org/10.1101/2022.07.01.497374
