Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Christy K. Holland"'
Autor:
Sonya R. Kennedy, Maxime Lafond, Kevin J. Haworth, Daniel Suarez Escudero, Dan Ionascu, Brion Frierson, Shaoling Huang, Melvin E. Klegerman, Tao Peng, David D. McPherson, Curtis Genstler, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory
Externí odkaz:
https://doaj.org/article/47b03a8ce6094d39a359e684fdee0ea0
Autor:
Robert T. Kleven, Kunal B. Karani, Nicole Hilvert, Samantha M. Ford, Karla P. Mercado-Shekhar, John M. Racadio, Marepalli B. Rao, Todd A. Abruzzo, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Adjuvant ultrasound at 2 MHz with or without an ultrasound contrast agent improves the rate of thrombus resolution by recombinant tissue plasminogen activator (rt-PA) in laboratory and clinical studies. A sub-megahertz approach can further e
Externí odkaz:
https://doaj.org/article/194cf381637f4fa18334d3a7647f19d8
Autor:
Samuel A. Hendley, Aarushi Bhargava, Christy K. Holland, Geoffrey D. Wool, Osman Ahmed, Jonathan D. Paul, Kenneth B. Bader
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Deep vein thrombosis is a major source of morbidity and mortality worldwide. For acute proximal deep vein thrombosis, catheter-directed thrombolytic therapy is an accepted method for vessel recanalization. Thrombolytic therapy is not without risk, in
Externí odkaz:
https://doaj.org/article/6ec4cc3db4474f1aae0bd2dea466d8be
Autor:
Patrick H. Kee, MD, PhD, Melanie R. Moody, BSc, Shao-Ling Huang, PhD, Hyunggun Kim, PhD, Xing Yin, MD, PhD, Tao Peng, MD, Susan T. Laing, MD, Melvin E. Klegerman, PhD, Mohammad H. Rahbar, PhD, Deborah Vela, MD, Curtis Genstler, MD, PhD, Kevin J. Haworth, PhD, Christy K. Holland, PhD, David D. McPherson, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 1-11 (2020)
Summary: Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide–loaded echogenic liposomes (ELIPs) and anti–
Externí odkaz:
https://doaj.org/article/6799d85165144a17bc107c5ee232352d
Autor:
Himanshu Shekhar, Robert T. Kleven, Tao Peng, Arunkumar Palaniappan, Kunal B. Karani, Shaoling Huang, David D. McPherson, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The development of adjuvant techniques to improve thrombolytic efficacy is important for advancing ischemic stroke therapy. We characterized octafluoropropane and recombinant tissue plasminogen activator (rt-PA)-loaded echogenic liposomes (O
Externí odkaz:
https://doaj.org/article/d1579c4e74a347bc8589b30a95b120f9
Autor:
Maxime Lafond, Himanshu Shekhar, Warunya Panmanee, Sydney D. Collins, Arunkumar Palaniappan, Cameron T. McDaniel, Daniel J. Hassett, Christy K. Holland
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
The global pandemic of antibiotic resistance is an ever-burgeoning public health challenge, motivating the development of adjunct bactericidal therapies. Nitric oxide (NO) is a potent bioactive gas that induces a variety of therapeutic effects, inclu
Externí odkaz:
https://doaj.org/article/e75a8c57a2e34682a3db24b3454787b2
Autor:
Kevin J. Haworth, Nuria Gonzales Salido, Maxime Lafond, Daniel Suarez Escudero, Christy K. Holland
Publikováno v:
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 70:498-509
Autor:
Daniel Suarez Escudero, Maxime Lafond, Nuria G. Salido, Kevin J. Haworth, Alexander S. Hannah, Gregory P. Macke, Curtis Genstler, Christy K. Holland
Publikováno v:
Ultrasound in Medicine & Biology. 49:410-414
Autor:
Christy K. Holland, Adam D. Maxwell, Kevin J. Haworth, Samuel A. Hendley, Kenneth B. Bader, Wayne Kreider
Publikováno v:
IEEE Trans Ultrason Ferroelectr Freq Control
Chronic thrombi of the deep veins of the leg are resistant to dissolution or removal by current interventions and can act as thrombogenic sources. Histotripsy, a focused ultrasound therapy, uses the mechanical activity of bubble clouds to liquefy tar
Autor:
Melvin E. Klegerman, Melanie R. Moody, Shao-Ling Huang, Tao Peng, Susan T. Laing, Vijay Govindarajan, Delia Danila, Amirali Tahanan, Mohammad H. Rahbar, Deborah Vela, Curtis Genstler, Kevin J. Haworth, Christy K. Holland, David D. McPherson, Patrick H. Kee
Publikováno v:
Journal of drug targeting. 31(1)
Peri-stent restenosis following stent implantation is a major clinical problem. We have previously demonstrated that ultrasound-facilitated liposomal delivery of pioglitazone (PGN) to the arterial wall attenuated in-stent restenosis. To evaluate ultr