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pro vyhledávání: '"Christy Job"'
Autor:
Christy Job, James Eberwine
Publikováno v:
Nature Reviews Neuroscience. 2:889-898
The neurons of the brain extend axons and dendrites many hundreds of micrometres away from the cell body. The first electron microscope studies of these processes revealed that many of the structures that are found in the cell body are also present i
Autor:
Christy Job, James Eberwine
Publikováno v:
Proceedings of the National Academy of Sciences. 98:13037-13042
Neuronal processes contain mRNAs and membrane structures, and some forms of synaptic plasticity seem to require protein synthesis in dendrites of hippocampal neurons. To quantitate dendritic protein synthesis, we used multiphoton microscopy of green
Publikováno v:
Proceedings of the National Academy of Sciences. 98:7080-7085
The functioning of the neuronal dendrite results from a variety of biological processes including mRNA transport to and protein translation in the dendrite. The complexity of the mRNA population in dendrites suggests that specific biological processe
Autor:
Leon Lagnado, Christy Job
Publikováno v:
The Journal of Cell Biology
The organization of filamentous actin (F-actin) in the synaptic pedicle of depolarizing bipolar cells from the goldfish retina was studied using fluorescently labeled phalloidin. The amount of F-actin in the synaptic pedicle relative to the cell body
Autor:
Jelena Blagojevic, Christopher H. Eskiw, Inês Faro Trindade, Monee Shamsher, Christy Job, David R. F. Carter, Jon Bartlett, Meng Xu, Peter R. Cook, Maud Fromaget
Publikováno v:
Biochemical Society symposium. (73)
We have previously suggested a model for the eukaryotic genome based on the structure of the bacterial nucleoid where active RNA polymerases cluster to loop the intervening DNA. This organization of polymerases into clusters--which we call transcript
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(21)
The selective subcellular localization of mRNAs to dendrites and the recent demonstration of local protein synthesis have highlighted the potential role of postsynaptic sites in modulation of cell–cell communication. We show that epitope-tagged sub
Publikováno v:
Neuron. 17(5)
Endocytosis and exocytosis were investigated in the synaptic terminal of retinal bipolar cells by monitoring the uptake and loss of the fluorescent dye FM1-43. Depolarization in the presence of Ca2+ stimulated a continuous cycle of exocytosis and end