Výsledky vyhledávání - "Christy J.W. Watson"

Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy

Autor: Keti Bardhi, Shelby Coates, Christy J.W. Watson, Philip Lazarus

Publikováno v: Expert Review of Clinical Pharmacology. 15:1443-1460

Cannabis is an increasingly popular recreational and medicinal drug in the USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on its use. With its increased usage, there is an increased possibility for potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b4e2f0c8ac180f6a8a28ab45aeb3f0
https://doi.org/10.1080/17512433.2022.2148655

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Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers

Autor: Yadira X. Perez-Paramo, Christy J.W. Watson, Gang Chen, Claire E. Thomas, Jennifer Adams-Haduch, Renwei Wang, Chiea Chuen Khor, Woon-Puay Koh, Heather H. Nelson, Jian-Min Yuan, Philip Lazarus

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 32:54-65

Background: Nicotine metabolism is a major factor in nicotine dependence, with approximately 70% to 80% of nicotine metabolized to cotinine in Caucasians. Cotinine formation is catalyzed primarily by CYP2A6, which also converts cotinine to trans-3′

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8299c068e2f913bcf9652eaf783c43a6
https://doi.org/10.1158/1055-9965.epi-22-0868

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Inhibition of the Aromatase Enzyme by Exemestane Cysteine Conjugates

Autor: Irina Teslenko, Christy J.W. Watson, Gang Chen, Philip Lazarus

Publikováno v: Molecular Pharmacology. 102:216-222

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a490b15e2cfbf827adf2294d2adaec3
https://doi.org/10.1124/molpharm.122.000545

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Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane

Autor: Irina Teslenko, Julia Trudeau, Shaman Luo, Christy J.W. Watson, Gang Chen, Cristina I. Truica, Philip Lazarus

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 382:327-334

Exemestane (EXE) is used to treat postmenopausal women diagnosed with estrogen receptor positive (ER+) breast cancer. A major mode of metabolism of EXE and its active metabolite, 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2270eeb1f55d2a0345583faff3db94
https://doi.org/10.1124/jpet.122.001232

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CYP2C19 Plays a Major Role in the HepaticN-Oxidation of Cotinine

Autor: Yadira X. Perez-Paramo, Christy J.W. Watson, Gang Chen, Philip Lazarus

Publikováno v: Drug Metabolism and Disposition. 51:29-37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2ecd1f15ff0bf4bf99f3363feda5b74
https://doi.org/10.1124/dmd.121.000624

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Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane

Autor: Zuping Xia, Christy J.W. Watson, Philip Lazarus, Irina L. Teslenko, Gang Chen

Publikováno v: Drug Metabolism and Disposition. 49:1047-1055

Exemestane (EXE) is a hormonal therapy used to treat estrogen receptor positive (ER+) breast cancer by inhibiting the final step of estrogen biosynthesis catalyzed by the enzyme aromatase. Cysteine conjugates of EXE and its active metabolite 17β-dih

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f73037df3d8f71eb1e721e2b0c1bcb3c
https://doi.org/10.1124/dmd.121.000635

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Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites

Autor: Christy J.W. Watson, Gang Chen, Philip Lazarus, Shamema Nasrin, Keti Bardhi, Gabriela Fort

Publikováno v: Drug Metabolism and Disposition. 49:1081-1089

The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous compounds. UGTs exhibit a high degree of structural similarity and display overlapping substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822b4897ba81688669c8c32d50ea790a
https://doi.org/10.1124/dmd.121.000530

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Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

Autor: Shamema Nasrin, Philip Lazarus, Christy J.W. Watson, Yadira X. Perez-Paramo

Publikováno v: Drug Metabolism and Disposition. 49:1070-1080

The legalization of cannabis in many parts of the United States and other countries has led to a need for a more comprehensive understanding of cannabis constituents and their potential for drug-drug interactions. While (-)-trans-Δ⁹-tetrahydrocann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1905197df68329f35ad3a55fab787ea8
https://doi.org/10.1124/dmd.121.000442

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