Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christy J W, Watson"'
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233111 (2020)
Bangladesh exhibits the second highest rate of smokeless tobacco (SLT) product usage in the world, and this has been associated with the high upper aerodigestive tract cancer incidence in this country. The goal of the present study was to examine the
Externí odkaz:
https://doaj.org/article/4faeb1d15ca642b3a77cc6b922368d5e
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0225044 (2020)
Cellular stress response mechanisms normally function to enhance survival and allow for cells to return to homeostasis following an adverse event. Cancer cells often co-opt these same mechanisms as a means to evade apoptosis and mitigate a state of c
Externí odkaz:
https://doaj.org/article/033a316359994377ab41cad556c7bac9
Autor:
Ross Jason Bindler, Christy J. W. Watson, Abram J. Lyons, Lillian Skeiky, Jamie Lewis, Michael McDonell, Philip Lazarus, Marian Wilson
Publikováno v:
Hospital pharmacy. 57(4)
Objective: To determine if a 2-day protocol measuring pharmacokinetic and pharmacodynamic characteristics can demonstrate drug-drug interactions when smoked cannabis is added to orally administered hydrocodone/acetaminophen combination products. Case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfd19eaad9844640ca982a60662f1c0
https://pubmed.ncbi.nlm.nih.gov/35898257
https://pubmed.ncbi.nlm.nih.gov/35898257
Publikováno v:
Chem Res Toxicol
The UDP-glycosyltransferase (UGT) family of enzymes are important in the metabolism of a variety of exogenous substances including polycyclic aromatic hydrocarbons (PAHs), a potent class of environmental carcinogens. As compared to the majority of UG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953b88bdfd4f7a18a650f6ba642ad7ea
https://doi.org/10.1021/acs.chemrestox.0c00233
https://doi.org/10.1021/acs.chemrestox.0c00233
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(12)
Exemestane (EXE) is a hormonal therapy used to treat estrogen receptor-positive breast cancer by inhibiting the final step of estrogen biosynthesis catalyzed by the enzyme aromatase. Cysteine conjugates of EXE and its active metabolite 17β-dihydro-E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74c82e3f38fde33f7d32884d0a9551a9
https://pubmed.ncbi.nlm.nih.gov/34593616
https://pubmed.ncbi.nlm.nih.gov/34593616
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 51(1)
The primary mode of metabolism of nicotine is via the formation of cotinine by the enzyme CYP2A6. Cotinine undergoes further CYP2A6-mediated metabolism by hydroxylation to 3-hydroxycotinine and norcotinine, but can also form cotinine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bb864de39745025e838d237acc1b513
https://pubmed.ncbi.nlm.nih.gov/35197312
https://pubmed.ncbi.nlm.nih.gov/35197312
Publikováno v:
Chem Res Toxicol
Tobacco specific nitrosamines (TSNAs) are among the most potent carcinogens found in cigarettes and smokeless tobacco products. Decreases in TSNA detoxification, particularly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), have been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f2dac1aeff10a60bf1c01ba0b69207
https://doi.org/10.1021/acs.chemrestox.9b00217
https://doi.org/10.1021/acs.chemrestox.9b00217
Autor:
Zeruesenay Desta, Philip Lazarus, Christy J. W. Watson, Jessica Bo Li Lu, Stephanie N. Liu, Brandon T. Gufford
Publikováno v:
Drug Metab Dispos
Integrase strand transfer inhibitor (INSTI)–based regimens dominate initial human immunodeficiency virus treatment. Most INSTIs are metabolized predominantly via UDP-glucuronosyltransferases (UGTs). For drugs predominantly metabolized by UGTs, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bee077d19e3e91712b496f4a8524203
https://doi.org/10.1124/dmd.118.085035
https://doi.org/10.1124/dmd.118.085035
Autor:
Christie D. Fowler, Jing Wang, Yen-Chu Chen, Philip Lazarus, Yasmine Sherafat, Andres Staben, Christy J. W. Watson, James P. Fowler, Travis T. Denton
Publikováno v:
The Journal of pharmacology and experimental therapeutics, vol 372, iss 1
J Pharmacol Exp Ther
J Pharmacol Exp Ther
During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cf8f9cb983bd70a427d0ee9a96d12f
https://escholarship.org/uc/item/4rj467pn
https://escholarship.org/uc/item/4rj467pn
Autor:
Gang Chen, Zuping Xia, Pramod Kumar Srivastava, Christy J. W. Watson, Travis T. Denton, Alec Wynd, Philip Lazarus
Publikováno v:
Journal of Medicinal Chemistry. 61:7065-7086
Cigarette smoking causes nearly one in every five deaths in the United States. The development of a specific inhibitor of cytochrome P450 2A6 (CYP2A6), the major nicotine-metabolizing enzyme in humans, which could be prescribed for the cessation of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb49a8edea1ca4174ca779181f81619
https://doi.org/10.1021/acs.jmedchem.8b00084
https://doi.org/10.1021/acs.jmedchem.8b00084