Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christy E. Trussoni"'
Autor:
Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhán Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Renã A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. McGowan, Nadiezhda Cantu-Medellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St. Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Niedernhofer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://doaj.org/article/d9a5a11c481f443f90c56186ddad5c93
Autor:
Jeong-Han Kang, Patrick L. Splinter, Christy E. Trussoni, Nicholas E. Pirius, Gregory J. Gores, Nicholas F. LaRusso, Steven P. O’Hara
Publikováno v:
Gastroenterology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e430647c4d44759c1ef689661d97bc13
https://doi.org/10.1053/j.gastro.2023.03.235
https://doi.org/10.1053/j.gastro.2023.03.235
Publikováno v:
Semin Immunopathol
The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are three cholangiopathies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0baf61744f4491d4074dd0ce288281f
https://doi.org/10.1007/s00281-022-00909-9
https://doi.org/10.1007/s00281-022-00909-9
Autor:
Anatoliy I. Masyuk, Tatyana V. Masyuk, Christy E. Trussoni, Nicholas E. Pirius, Nicholas F. LaRusso
Publikováno v:
Hepatology
Polycystic liver disease (PLD) is characterized by defective cholangiocyte cilia that regulate progressive growth of hepatic cysts. Because formation of primary cilia is influenced by autophagy through degradation of proteins involved in ciliogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a13bafc2da945d7580760b3c9674d10
https://doi.org/10.1002/hep.32298
https://doi.org/10.1002/hep.32298
Autor:
Ryan D. O’Kelly, Dong Wang, Tokio Sano, Warren C. Ladiges, Yinsheng Wang, Kyoo a. Lee, Johnny Huard, Sara J. McGowan, Ingunn M. Stromnes, Rafael R. Flores, Sara E. Lewis, Laura J. Niedernhofer, Robert W. Brooks, Aiping Lu, Zoe C. Schmiechen, Michael P. Bank, Nam Vo, Jenna Klug, Adam L. Burrack, Luise A. Angelini, Nicholas F. LaRusso, Qing Dong, Paul D. Robbins, Matthew J. Yousefzadeh, Christy E. Trussoni, Christin E. Burd, Smitha P. S. Pillai, Jonathan I. Kato, Yi Zhu, Yuxiang Cui, Erin A. Wade, Collin A. McGuckian, Eric E. Kelley
Publikováno v:
Nature
Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly(1,2). To define the contribution of immune system ageing to organism ageing, here we selectively deleted Ercc1, which encodes a crucial DNA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d275b4eb33eb547755f33cc3b4b5781d
https://doi.org/10.1038/s41586-021-03547-7
https://doi.org/10.1038/s41586-021-03547-7
Autor:
Maria Eugenia Guicciardi, Adiba I. Azad, Gregory J. Gores, Tomohiro Katsumi, Anuradha Krishnan, Nazli B. Ozturk, Christy E. Trussoni
Publikováno v:
Am J Pathol
The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cholestatic liver disease is unclear. Herein, we examined TRAIL receptor signaling in a mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b3e8b9ea4f100ca68d179a5602476e
https://doi.org/10.1016/j.ajpath.2020.02.013
https://doi.org/10.1016/j.ajpath.2020.02.013
Autor:
Tatyana V. Masyuk, Jingyi Ding, Christy E. Trussoni, Bing Huang, Nicholas F. LaRusso, Brynn N. Howard, Anatoliy I. Masyuk
Publikováno v:
JHEP Reports, Vol 3, Iss 5, Pp 100345-(2021)
Background & Aims Polycystic liver disease (PLD) is characterised by increased autophagy and reduced miRNA levels in cholangiocytes. Given that autophagy has been implicated in miRNA regulation, we tested the hypothesis that increased autophagy accou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f58305089d40740cf196e55b8a3de9
http://www.sciencedirect.com/science/article/pii/S258955592100121X
http://www.sciencedirect.com/science/article/pii/S258955592100121X
Autor:
Lorena Loarca, Lorena Marcano Bonilla, Nicholas F. LaRusso, Maria J. Lorenzo Pisarello, Eugene W. Krueger, Gregory J. Gores, Guang Shi, Anuradha Krishnan, Christy E. Trussoni, Bing Huang, Leslie Morton, Robert C. Huebert, Steve F. Bronk, Patrick L. Splinter, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar, Steve P. O'Hara
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Primary sclerosing cholangitis (PSC) is an incurable, fibroinflammatory biliary disease for which there is no effective pharmacotherapy. We recently reported cholangiocyte senescence as an important phenotype in PSC while others showed that portal ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2973f6954cfbab5a68ca89fd696d72d
http://europepmc.org/articles/PMC5664217
http://europepmc.org/articles/PMC5664217
Autor:
Bryce F. Schutte, Christy E. Trussoni, Maria J. Lorenzo Pisarello, Noah S. Splinter, Steven P. O'Hara, Patrick L. Splinter, Nicholas F. LaRusso, Lorena Loarca
Publikováno v:
Journal of Biological Chemistry. 292:4833-4846
Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (disease of the bile ducts) of unknown pathogenesis. We reported that cholangiocyte senescence features prominently in PSC and that neuroblastoma RAS viral oncogene h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca3054ee03b861126a77363d9d5a6e3
https://doi.org/10.1074/jbc.m117.777409
https://doi.org/10.1074/jbc.m117.777409
Publikováno v:
Hepatology
Cholangiocytes are the target of a group of chronic liver diseases termed the "cholangiopathies," in which cholangiocytes react to exogenous and endogenous insults, leading to disease initiation and progression. In primary sclerosing cholangitis (PSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c89114cfeeca704180e9eaef669f85b
https://pubmed.ncbi.nlm.nih.gov/31833071
https://pubmed.ncbi.nlm.nih.gov/31833071