Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christy C. Ong"'
Autor:
Christy C. Ong, D. Bradley Welling, Zeng-Jie Yang, Jonathan Chernoff, Klaus P. Hoeflich, Sergio G. Durón, Long-Sheng Chang, Biao Dong, David A. Campbell, Hoi-Yee Chow
Publikováno v:
Oncotarget
// Hoi-Yee Chow 1, * , Biao Dong 2, * , Sergio G. Duron 3 , David A. Campbell 3 , Christy C. Ong 4 , Klaus P. Hoeflich 4 , Long-Sheng Chang 5, 6, 7 , D. Bradley Welling 7 , Zeng-jie Yang 1 , Jonathan Chernoff 1 1 Cancer Biology Program, Fox Chase Can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae90434789f3a7cf06ee71e106de57b
http://europepmc.org/articles/PMC4385830
http://europepmc.org/articles/PMC4385830
Autor:
Qian Xiao, Adrian M. Jubb, Robert Grützmann, Wei Zhou, Daniela Aust, Mark Merchant, William F. Forrest, Lei Zheng, Hartmut Koeppen, Elizabeth M. Jaffee, Qinghua Song, Ana De Jesus-Acosta, Klara Totpal, Florian Gnad, Christy C. Ong, Lori Friedman, Karen Lyle, Ling Fu, Mally Romero, Richard M. Neve, Marcia Belvin, Yulei Wang, Yibing Yan, Christian Pilarsky, Rajiv Raja, Klaus P. Hoeflich, Peter M. Haverty, Rupal Desai
Publikováno v:
The Journal of Pathology. 234:502-513
Pancreatic adenocarcinoma (PDAC) is a major unmet medical need and a deeper understanding of molecular drivers is needed to advance therapeutic options for patients. We report here that p21-activated kinase 1 (PAK1) is a central node in PDAC cells do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744877301fdc27d71db43376f47d2e2d
https://doi.org/10.1002/path.4412
https://doi.org/10.1002/path.4412
Autor:
Karl A. Merrick, Georgia Hatzivassiliou, Thomas O'Brien, Anneleen Daemen, Christy C. Ong, Lori Friedman
Publikováno v:
Cancer Research. 79:P5-04
Estrogen Receptor positive (ER+) breast cancer accounts for the majority of breast cancer cases and standard of care for these tumors is treatment with endocrine therapy, including the blockade of estrogen production (i.e. aromatase inhibitors; AIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f0361b6e4c6b396eecd8d8b4d72e94
https://doi.org/10.1158/1538-7445.sabcs18-p5-04-26
https://doi.org/10.1158/1538-7445.sabcs18-p5-04-26
Autor:
Audrey Minden, Karen Lyle, Marcia Belvin, Lori Friedman, Amy Young, Wei Zhou, Florian Gnad, Matthew P. Stokes, Hartmut Koeppen, Jeffrey C. Silva, Klaus P. Hoeflich, Christy C. Ong
Publikováno v:
Molecular & Cellular Proteomics. 12:2070-2080
Although K-Ras, Cdc42, and PAK4 signaling are commonly deregulated in cancer, only a few studies have sought to comprehensively examine the spectrum of phosphorylation-mediated signaling downstream of each of these key signaling nodes. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda90900f3514f21c8d5e0c701999218
https://doi.org/10.1074/mcp.m112.027052
https://doi.org/10.1074/mcp.m112.027052
Autor:
Marcin Kowanetz, Jarrod Tremayne, Christy C. Ong, Elizabeth Blackwood, Yibing Yan, Marcia Belvin, Hartmut Koeppen, Adrian M. Jubb, Mark R. Middleton, Peter M. Haverty, Richard Lisle, Diana Jakubiak, Joachim Rudolph, Wei Zhou, Adrian L. Harris, Lori Friedman, Klaus P. Hoeflich
BACKGROUND: Although remarkable clinical response rates in melanoma have been observed using vemurafenib or dabrafenib in patients with tumors carrying oncogenic mutations in BRAF, a substantial unmet medical need remains for the subset of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e867682a4720b30f9f0b08efdd7ea26c
https://doi.org/10.1093/jnci/djt054
https://doi.org/10.1093/jnci/djt054
Autor:
Marcia Belvin, Adrian M. Jubb, Wei Zhou, Lori Friedman, Peter M. Haverty, Christy C. Ong, Klaus P. Hoeflich, Adrian L. Harris, Hartmut Koeppen
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. This raises the possibility that interfering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca98b7223a6332ee896d5f521a0b4953
https://ora.ox.ac.uk/objects/uuid:81db76ce-1231-4afa-ad19-3c2f02f5bcb8
https://ora.ox.ac.uk/objects/uuid:81db76ce-1231-4afa-ad19-3c2f02f5bcb8
Autor:
Jennifer Epler, Joachim Rudolph, Joy Drobnick, Roxanne Vega, Ignacio Aliagas, Sreemathy Ramaswamy, Elizabeth Blackwood, Klaus P. Hoeflich, Diana Jakubiak, Wendy Lee, Haiming Zhang, Xianrui Zhao, Weiru Wang, Christopher E. Heise, David Favor, Chudi Ndubaku, Thomas W. O'Brien, Gary A. Cain, Lesley J. Murray, Paroma Chakravarty, Hank La, Christy C. Ong, Ping Dong, Connie Chan, James J. Crawford, Angela Oh, Yu Zhong, Dolores Díaz, Lewis J. Gazzard
Publikováno v:
Journal of medicinal chemistry. 59(11)
p21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be5f9cfb402a0bbeedbcf126e00c2a
https://pubmed.ncbi.nlm.nih.gov/27167326
https://pubmed.ncbi.nlm.nih.gov/27167326
Publikováno v:
Cancer Research. 77:P3-04
Estrogen positive (ER+) breast cancer accounts for the majority of all breast cancers and standard practice is treatment with endocrine therapy. Recently a series of CDK4/6 inhibitors have emerged that can be effectively combined with estrogen modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95c8a579612176f026aa4030d722658
https://doi.org/10.1158/1538-7445.sabcs16-p3-04-24
https://doi.org/10.1158/1538-7445.sabcs16-p3-04-24
Autor:
Jonathan Chernoff, Min Shen, Joachim Rudolph, Hartmut Koeppen, Andrew R. Green, Maike Schmidt, Carlos Caldas, Emad A. Rakha, Wenwei Huang, Suet-Feung Chin, Ian O. Ellis, Peter M. Haverty, Christy C. Ong, Wei Zhou, Lori Friedman, William F. Forrest, Sarah Gierke, Sergio G. Durón, Wei Zheng, Christine K. Cheng, Seameen Dehdashti, Thomas O'Brien, Nora Yang, Klaus P. Hoeflich, Adrian M. Jubb, Meredith Sagolla, John C. McKew, David A. Campbell, Mark Behnke, Cameron Pitt, Laura A Strickland
Publikováno v:
Breast Cancer Research : BCR
Introduction Breast cancer, the most common cause of cancer-related deaths worldwide among women, is a molecularly and clinically heterogeneous disease. Extensive genetic and epigenetic profiling of breast tumors has recently revealed novel putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8a7a729df9309fef045de72fba5957
https://doi.org/10.1186/s13058-015-0564-5
https://doi.org/10.1186/s13058-015-0564-5
Autor:
Sandra S. Zinkel, Christy C. Ong, Atan Gross, Kristen E. Hurov, Stanley J. Korsmeyer, Farvardean M. Abtahi
Publikováno v:
Cell. 122:579-591
SummaryThe BCL-2 family of apoptotic proteins encompasses key regulators proximal to irreversible cell damage. The BH3-only members of this family act as sentinels, interconnecting specific death signals to the core apoptotic pathway. Our previous da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291aaed2853957d93935ef2764a2f6e6
https://doi.org/10.1016/j.cell.2005.06.022
https://doi.org/10.1016/j.cell.2005.06.022