Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christy Brookes"'
Autor:
Bob Argiropoulos, Stephen Fung, Courteney Lai, Peter J. M. Valk, Florian Kuchenbauer, Grace Lin, R. Keith Humphries, Andrew P. Weng, Ruud Delwel, Laura M. Sly, Gerald Krystal, Bob Löwenberg, Christy Brookes, Michael Heuser, Malina Leung
Publikováno v:
Blood, 114(19), 3983-3993. American Society of Hematology
Although the cancer stem cell (CSC) concept implies that CSCs are rare, recent reports suggest that CSCs may be frequent in some cancers. We hypothesized that the proportion of leukemia stem cells would vary as a function of the number of dysregulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87884ab60896648d8d7f2f00094cb1fa
https://doi.org/10.1182/blood-2009-06-227603
https://doi.org/10.1182/blood-2009-06-227603
Autor:
Jill E. Kucab, Valentina Evdokimova, Sandra E. Dunn, C. Blake Gilks, Christy Brookes, Torsten O. Nielsen, Leonard M. Neckers, Heather N. Andrews, David G. Huntsman, Nikita Makretsov, Forrest D. Hsu, Maggie C.U. Cheang, Joseph Ragaz, Chris Bajdik
Publikováno v:
Cancer Research. 64:286-291
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of >1000 compounds, 17-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7756af3e1bfcecd8b5f69a78b1f4b5c2
https://doi.org/10.1158/0008-5472.can-03-1242
https://doi.org/10.1158/0008-5472.can-03-1242
Autor:
Christy Brookes, Adrian Wan, Veronique Lecault, James M. Piret, Patty Rosten, Corinne A. Hoesli, Clayton A. Smith, David G. Kent, Carl L. Hansen, Maura Gasparetto, R. Keith Humphries, Sanja Sekulovic, Connie J. Eaves
Publikováno v:
Blood. 118(16)
Achieving high-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important clinical impact in addition to enabling elucidation of their regulation. Here, we couple the ability of engineered NUP98-HOXA10hd expression to stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d2991954aa682252700f9b3b448903
https://pubmed.ncbi.nlm.nih.gov/21865344
https://pubmed.ncbi.nlm.nih.gov/21865344
Autor:
Fabio M.V. Rossi, Clayton A. Smith, Yasmine Even, Peter M. Lansdorp, Christy Brookes, Sanja Sekulovic, Vala Gylfadottir, Irma Vulto, Maura Gasparetto, R. Keith Humphries, Connie J. Eaves
Publikováno v:
Blood. 118(7)
Strategies for expanding hematopoietic stem cells (HSCs) could have significant utility for transplantation-based therapies. However, deleterious consequences of such manipulations remain unknown. Here we examined the impact of HSC self-renewal divis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f5e1d346e73c11f48ff66a99b0eccf
https://pubmed.ncbi.nlm.nih.gov/21730353
https://pubmed.ncbi.nlm.nih.gov/21730353
Autor:
Nicolas Pineault, Cynthia L. Fisher, Hugh W. Brock, Christy Brookes, R. Keith Humphries, Hideaki Ohta, Jay L. Hess, Cheryl D. Helgason, Caroline Bodner
The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is required to maintain both activation and silencing of Hox genes in flies and mice. Asxl prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9a51d9446eb89d64c31db680fff828
https://europepmc.org/articles/PMC2803690/
https://europepmc.org/articles/PMC2803690/
Autor:
Torsten O, Nielsen, Heather N, Andrews, Maggie, Cheang, Jill E, Kucab, Forrest D, Hsu, Joseph, Ragaz, C Blake, Gilks, Nikita, Makretsov, Chris D, Bajdik, Christy, Brookes, Leonard M, Neckers, Valentina, Evdokimova, David G, Huntsman, Sandra E, Dunn
Publikováno v:
Cancer research. 64(1)
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of1000 compounds, 17-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::285563df634236803e489967eed25ad4
https://pubmed.ncbi.nlm.nih.gov/14729636
https://pubmed.ncbi.nlm.nih.gov/14729636
Autor:
Bob Argiropoulos, Laura M. Sly, Gerald Krystal, Stephen Fung, R. Keith Humphries, Christy Brookes, Courteney Lai, Michael Heuser, Malina Leung, Florian Kuchenbauer, Grace Lin
Publikováno v:
Blood. 112:1355-1355
Leukemias are considered hierarchically organized being maintained by a leukemia stem cell (LSC). Whereas LSCs become the primary focus for targeted therapies, little is known about the pathways regulating LSC fidelity. Using retroviral gene transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3eb1dff0205e1f57bf5d443632e26d
https://doi.org/10.1182/blood.v112.11.1355.1355
https://doi.org/10.1182/blood.v112.11.1355.1355
Publikováno v:
Blood. 110:3380-3380
Leukemias are considered hierarchically organized where a leukemia stem cell (LSC) maintains the disease, can reinitiate disease upon transplantation, and gives rise to more mature cells which can not establish the disease after secondary transplanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b5de09fca1139364da4881467f05aee
https://doi.org/10.1182/blood.v110.11.3380.3380
https://doi.org/10.1182/blood.v110.11.3380.3380