CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Autor: Athmane Teghanemt, Priyanjali Pulipati, Kara Misel-Wuchter, Kenneth Day, Matthew S. Yorek, Ren Yi, Henry L. Keen, Christy Au, Thorsten Maretzky, Prajwal Gurung, Dan R. Littman, Priya D. Issuree

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Epigenetic states that are established during thymic T cell development influence functionality of mature T cells. Authors here show that early developmental programming of the Cd4 locus is comprised of DNA-demethylation at a specific stimulus-respon

Externí odkaz: https://doaj.org/article/482db9321db34efd98079e36a3067f0a

Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex

Autor: Michael Tramantano, Lu Sun, Christy Au, Daniel Labuz, Zhimin Liu, Mindy Chou, Chen Shen, Ed Luk

Publikováno v: eLife, Vol 5 (2016)

The assembly of the preinitiation complex (PIC) occurs upstream of the +1 nucleosome which, in yeast, obstructs the transcription start site and is frequently assembled with the histone variant H2A.Z. To understand the contribution of the transcripti

Externí odkaz: https://doaj.org/article/f192fa339f2b4d3cbef3f2cce5cdc0c7

Epigenetic Programming during thymic development sets the stage for optimal function in effector T cells via DNA demethylation

Autor: Athmane Teghanemt, Priyanjali Pulipati, Kenneth Day, Matt Yorek, Ren Yi, Kara Misel-Wuchter, Henry L Keen, Christy Au, Thorsten Maretzky, Prajwal Gurung, Dan R. Littman, Priya D. Issuree

The repressive effect of DNA methylation at promoters is well-known. However, its role within conserved sequences in intragenic and intergenic regions is less clear. Using Cd4 as a model gene, here we show that DNA methylation regulates the function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3014e0b313628b9e65f2531cff76d2f
https://doi.org/10.1101/2021.05.03.442517

Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development

Autor: Jane A. Skok, Richard M. Myers, Dan R. Littman, Hai-Hui Xue, Priya D. Issuree, Ramya Raviram, Paul Zappile, Christy Au, Kenneth Day

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications

The inheritance of gene expression patterns is dependent on epigenetic regulation, but the establishment and maintenance of epigenetic landscapes during T cell differentiation are incompletely understood. Here we show that two stage-specific Cd4 cis-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75926369be397fe000d3285bf2bf6710
http://link.springer.com/article/10.1038/s41467-018-05834-w

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells

Autor: Benjamin Hubert, Geneviève Almouzni, Lin Wu, Christy Au, Jean-Pierre Quivy, Tung T. Nguyen, Kai R. Mesa, Will Liao, Tariq Ahmad Najar, Dan R. Littman, Charles Ng, Martin Aichinger, Johannes Zuber

Publikováno v: Genes and Development
Genes and Development, 2019, 33 (11-12), pp.669-683. ⟨10.1101/gad.322024.118⟩
Genes & Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2019, 33 (11-12), pp.669-683. ⟨10.1101/gad.322024.118⟩

The transcriptional repression of alternative lineage genes is critical for cell fate commitment. Mechanisms by which locus-specific gene silencing is initiated and heritably maintained during cell division are not clearly understood. To study the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fa5de5c97c418819e11e88486fb91d
https://hal.science/hal-02326664