Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Christy A Harrison"'
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Akademický článek
Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis.
Autor: Daniel Laubitz, Christy A Harrison, Monica T Midura-Kiela, Rajalakshmy Ramalingam, Claire B Larmonier, John H Chase, J Gregory Caporaso, David G Besselsen, Fayez K Ghishan, Pawel R Kiela
Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152044 (2016)
Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na+/H+ exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na+/H+ exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis.
Externí odkaz: https://doaj.org/article/28718da128c4495d846ae57976e9def3
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2
Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell–Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction
Autor: Raji V Marati, Monica T. Midura-Kiela, David G. Besselsen, Fayez K. Ghishan, Pawel R. Kiela, Deepa R. Jamwal, Vanessa R Figliuolo Paz, Christy A. Harrison
Publikováno v: Inflamm Bowel Dis
Background Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef66ceae595536c57c9b6d2499593173
https://doi.org/10.1093/ibd/izz191
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3
Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis
Autor: Daniel Laubitz, Deepa R. Jamwal, Pawel R. Kiela, Monica T. Midura-Kiela, Fayez K. Ghishan, Christy A. Harrison, David G. Besselsen
Publikováno v: Journal of Crohn's and Colitis. 13:115-126
Background Broad-spectrum antibiotics [Abx], including combination therapy with ciprofloxacin and metronidazole, are often prescribed during the treatment of inflammatory bowel disease [IBD] to alleviate symptoms, but with varying success. In this pi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fda2ae3c3b7dbfbf636fa295d6949cb
https://doi.org/10.1093/ecco-jcc/jjy144
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4
Microbial Dysbiosis Associated with Impaired Intestinal Na+/H+ Exchange Accelerates and Exacerbates Colitis in Ex-Germ Free Mice
Autor: Christy A. Harrison, Fayez K. Ghishan, Pawel R. Kiela, Deepa R. Jamwal, Christina L. Ohland, Daniel Laubitz, Christian Jobin, Monica T. Midura-Kiela, David G. Besselsen, Karuna Patil
Publikováno v: Mucosal immunology
Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3fa33768de5c8aeefa2483cbdd85a6
http://europepmc.org/articles/PMC6162102
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5
How poverty affects diet to shape the microbiota and chronic disease
Autor: Christy A. Harrison, Douglas Taren
Publikováno v: Nature Reviews Immunology. 18:279-287
Here, we discuss the link between nutrition, non-communicable chronic diseases and socio-economic standing, with a special focus on the microbiota. We provide a theoretical framework and several lines of evidence from both animal and human studies th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfb3ecb6b30d0d25e1751eaf4f7a8db
https://doi.org/10.1038/nri.2017.121
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6
Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells
Autor: Vanessa Figliuolo da Paz, Deepa R. Jamwal, Michael Gurney, Monica Midura-Kiela, Christy A. Harrison, Christopher Cox, Jean M. Wilson, Fayez K. Ghishan, Pawel R. Kiela
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Dendritic cells (DCs) are pivotal in regulating tolerogenic as well as immunogenic responses against microorganisms by directing both the innate and adaptive immune response. In health, phenotypically different DC subsets found in the gut mucosa are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011d188b015d32debd513116658261b9
https://doi.org/10.3389/fimmu.2019.00304
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8
Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis
Autor: John Chase, J. Gregory Caporaso, Pawel R. Kiela, Christy A. Harrison, Monica T. Midura-Kiela, David G. Besselsen, Fayez K. Ghishan, Claire B. Larmonier, Rajalakshmy Ramalingam, Daniel Laubitz
Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152044 (2016)
PLoS ONE
Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na+/H+ exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na+/H+ exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6195836336d8312847d0e065d0fc53f9
http://europepmc.org/articles/PMC4822813?pdf=render
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