Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christos Tzitzilonis"'
Autor:
Nathan M. Fastman, Yuxi Liu, Vyas Ramanan, Hanne Merritt, Eileen Ambing, Anna A. DePaoli-Roach, Peter J. Roach, Thomas D. Hurley, Kevin T. Mellem, Julie C. Ullman, Eric Green, David Morgans, Jr., Christos Tzitzilonis
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111041- (2022)
Summary: Glycogen is the primary energy reserve in mammals, and dysregulation of glycogen metabolism can result in glycogen storage diseases (GSDs). In muscle, glycogen synthesis is initiated by the enzymes glycogenin-1 (GYG1), which seeds the molecu
Externí odkaz:
https://doaj.org/article/48c6548bd0854270915cfc7f6ac2d38f
Autor:
Roberto Jappelli, Marilyn H Perrin, Kathy A Lewis, Joan M Vaughan, Christos Tzitzilonis, Jean E Rivier, Wylie W Vale, Roland Riek
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84013 (2014)
Corticotropin-Releasing Factor Receptors (CRFRs) are class B1 G-protein-coupled receptors, which bind peptides of the corticotropin releasing factor family and are key mediators in the stress response. In order to dissect the receptors' binding speci
Externí odkaz:
https://doaj.org/article/b0a3342705b14838a2d1dd64b266fc0e
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54378 (2013)
Because membrane proteins need to be extracted from their natural environment and reconstituted in artificial milieus for the 3D structure determination by X-ray crystallography or NMR, the search for membrane mimetic that conserve the native structu
Externí odkaz:
https://doaj.org/article/415b42b0ad11455e85c4b004f29959b4
Autor:
G. Leslie Burnett, Yu C. Yang, James B. Aggen, Jennifer Pitzen, Micah K. Gliedt, Chris M. Semko, Abby Marquez, James W. Evans, Gang Wang, Walter S. Won, Aidan C. A. Tomlinson, Gert Kiss, Christos Tzitzilonis, Arun P. Thottumkara, James Cregg, Kevin T. Mellem, Jong S. Choi, Julie C. Lee, Yongyuan Zhao, Bianca J. Lee, Justin G. Meyerowitz, John E. Knox, Jingjing Jiang, Zhican Wang, David Wildes, Zhengping Wang, Mallika Singh, Jacqueline A. M. Smith, Adrian L. Gill
Publikováno v:
Journal of Medicinal Chemistry. 66:149-169
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric inhibitors of mTORC1 and orthosteric dual inhibitors of mTORC1 and mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cb750ad287b7aa33c649c1e4fa24c0
https://doi.org/10.1021/acs.jmedchem.2c01658
https://doi.org/10.1021/acs.jmedchem.2c01658
Autor:
Mallika Singh, Abby Marquez, Carlos Stahlhut, David Wildes, Mark A. Goldsmith, Zhengping Wang, Victor Olivas, Jacqueline Smith, Collin M. Blakely, Christos Tzitzilonis, Golzar Hemmati, Caroline E. McCoach, Kasia Mordec, Adrian Liam Gill, Gert Kiss, Tientien Hsieh, Christopher J. Schulze, Trever G. Bivona, Franziska Haderk, Aubhishek Zaman, Elena S. Koltun, Jason Romero, Robert J. Nichols
Publikováno v:
Nature cell biology
Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAFV600E-driven cancers, effective targeted therapies are lacking for most cancers driven by o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54773dd67116432d3f5dfcac072a5648
https://doi.org/10.1038/s41556-018-0169-1
https://doi.org/10.1038/s41556-018-0169-1
Autor:
Christos Tzitzilonis, Elena S. Koltun, Trever G. Bivona, Mallika Singh, Daphne Hsieh, Robert J. Nichols, Christopher J. Schulze, Jason Romero, Jacqueline Smith, Abby Marquez, Franziska Haderk, Kasia Mordec, Carlos Stahlhut, Adrian Liam Gill, Gert Kiss, Mark A. Goldsmith, Golzar Hemmati, David Wildes
Oncogenic alterations in the RAS-RAF-MEK-ERK pathway, including mutant forms of KRAS, BRAF, and loss of the tumor suppressor and RAS GTPase-activating protein (GAP) NF1, drive the growth of a wide spectrum of human cancers. While BRAF and MEK inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ed40580c12f3d688f34996884655b
S-Sulfhydration of the Catalytic Cysteine in the Rhodanese Domain of YgaP is Complex Dynamic Process
Publikováno v:
Matters
Matters
ISSN:2297-8240
ISSN:2297-8240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e980c23cf58e47d81b908bbda8093a
Autor:
Ashutosh S. Jogalekar, Mellem Kevin, Chris M. Semko, Andreas Buckl, Elena S. Koltun, Jacqueline Smith, Naing Aay, Mallika Singh, Christos Tzitzilonis, Robert J. Nichols, Won Walter, Nidhi Tibrewal, Zhengping Wang, Kasia Mordec, Adrian Liam Gill, Gert Kiss, Abby Marquez, Susan E. Wilson, Mae Saldajeno-Concar, David Wilds
Publikováno v:
Cancer Research. 78:4878-4878
Genetic and pharmacologic evidence has shown that SHP2, a non-receptor protein tyrosine phosphatase (PTP) and scaffold protein encoded by the PTPN11 gene, is a convergent signal transduction node that integrates growth factor signals from multiple re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9799dbbd6e549ae1405a9baa4fbc959
https://doi.org/10.1158/1538-7445.am2018-4878
https://doi.org/10.1158/1538-7445.am2018-4878
Autor:
Adrian Liam Gill, Gert Kiss, Daphne Hsieh, Jacqueline Smith, Robert J. Nichols, Chris M. Semko, Naing Aay, Ashutosh S. Jogalekar, Mellem Kevin, Mae Saldajeno-Concar, David Wildes, Won Walter, Andreas Buckl, Christopher J. Schulze, Carlos Stahlhut, Jason Romero, Christos Tzitzilonis, Elena S. Koltun, Abby Marquez
Publikováno v:
Cancer Research. 78:4877-4877
SHP2 (PTPN11) is a non-receptor protein tyrosine phosphatase and scaffold protein that functions in multiple signal transduction pathways. Genetic and pharmacologic evidence supports a role for SHP2 in driving the proliferation of cancer cells depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ded4958643dc44622b33737ce5fb4d
https://doi.org/10.1158/1538-7445.am2018-4877
https://doi.org/10.1158/1538-7445.am2018-4877
Autor:
Tomohiro Nakamura, John R. Yates, Brendan P. Eckelman, Guy S. Salvesen, Fanjun Meng, Christos Tzitzilonis, Xuemei Han, Lei Wang, Shu-ichi Okamoto, Roland Riek, Arjay Clemente, Stuart A. Lipton, Catherine C. L. Wong, Zezong Gu, Emily A. Holland, Fiona L. Scott
Publikováno v:
Molecular Cell. 39:184-195
X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase apoptotic activity. XIAP also functions as an E3 ubiquitin ligase, targeting caspases for degradation. However, molecular pathways controlling XIAP activities remain unclear. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b2fe5674114058fdc16c199b0897a6
https://doi.org/10.1016/j.molcel.2010.07.002
https://doi.org/10.1016/j.molcel.2010.07.002