Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christos Tzimas"'
Autor:
Benjamin Klocke, Aikaterini Britzolaki, Joseph Saurine, Hayden Ott, Kylie Krone, Kiara Bahamonde, Connor Thelen, Christos Tzimas, Despina Sanoudou, Evangelia G. Kranias, Pothitos M. Pitychoutis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The thalamic reticular nucleus (TRN) is a brain region that influences vital neurobehavioral processes, including executive functioning and the generation of sleep rhythms. TRN dysfunction underlies hyperactivity, attention deficits, and sle
Externí odkaz:
https://doaj.org/article/111c82fc7a3544e4b516588cc3b18349
Autor:
Michael I. Brener, Michelle L. Hulke, Nobuaki Fukuma, Stephanie Golob, Robert S. Zilinyi, Zhipeng Zhou, Christos Tzimas, Ilaria Russo, Claire McGroder, Ryan D. Pfeiffer, Alexander Chong, Geping Zhang, Daniel Burkhoff, Martin B. Leon, Mathew S. Maurer, Jeffrey W. Moses, Anne-Catrin Uhlemann, Hanina Hibshoosh, Nir Uriel, Matthias J. Szabolcs, Björn Redfors, Charles C. Marboe, Matthew R. Baldwin, Nathan R. Tucker, Emily J. Tsai
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute cardiac injury is prevalent in critical COVID-19 and associated with increased mortality. Its etiology remains debated, as initially presumed causes — myocarditis and cardiac necrosis — have proved uncommon. To elucidate the pathophysiology
Externí odkaz:
https://doaj.org/article/2de2e76911bc473598fb90fee54b07f0
Publikováno v:
Global Cardiology Science & Practice, Vol 2012, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/ed9da4ae6a23406c8714b9f5485a8e88
Autor:
Robert Zilinyi, Emily J. Tsai, Alexander M. Chong, Nathan R. Tucker, Nobuaki Fukuma, Anne-Catrin Uhlemann, Zhipeng Zhou, Ryan D Pfeiffer, Matthias Szabolcs, Mathew S. Maurer, Christos Tzimas, Martin B. Leon, Michelle L Hulke, Geping Zhang, Stephanie Golob, Nir Uriel, Matthew R. Baldwin, Claire McGroder, Charles C. Marboe, Ilaria Russo, Michael I. Brener, Jeffrey W. Moses, Björn Redfors, Daniel Burkhoff, Hanina Hibshoosh
Cardiac injury is associated with critical COVID-19, yet its etiology remains debated. To elucidate the pathogenic mechanisms of COVID-19-associated cardiac injury, we conducted a single-center prospective cohort study of 69 COVID-19 decedents. Of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21254c634de7a6a493127b8ec834fb3
https://doi.org/10.1101/2021.07.27.453843
https://doi.org/10.1101/2021.07.27.453843
Publikováno v:
Circulation Research. 127
Background: In HFpEF and PAH, men are more likely than women to develop right ventricular dysfunction (RVD) and die. Mechanisms underlying these sex differences are not well understood. In advanced HF patients, RVD is associated with RV fibrosis. Sex
Publikováno v:
Circulation Research. 127
Objectives: The nitric oxide (NO) receptor soluble guanylyl cyclase (GC-1) can localize to cell membrane microdomains, including caveolae. In failing hearts, GC-1 relocalizes away from caveolae and becomes oxidized. How this occurs is unknown. We hyp
Autor:
David J. Robbins, Christos Tzimas, Wen Zhou, Prathibha Ranganathan, Luisana Astudillo, Anthony J. Capobianco, Xiaoxia Zhu, Ke Jin, Kelly L. Weaver, Xiaoqing Han, Bin Li
Publikováno v:
Molecular Cancer Research. 15:1173-1183
It is well established that Notch functions as a transcriptional activator through the formation of a ternary complex that comprises Notch, Maml, and CSL. This ternary complex then serves to recruit additional transcriptional cofactors that link to h
Autor:
Evangelia G. Kranias, Michalis Katsimpoulas, Constantinos A. Dimitriou, Stephan E. Lehnart, Doron Shmerling, Despina Sanoudou, Daniel M. Johnson, Constantinos H. Davos, Nikolaos C. Athanasiadis, Stephan Sonntag, Mariya Kryzhanovska, Karin R. Sipido, Demetrios A. Arvanitis, Aimilia Varela, Christos Tzimas, Demetrio J. Santiago, Elizabeth Vafiadaki
Publikováno v:
Cardiovascular Research. 113:1403-1417
Aims The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy. Herein, the role o
Autor:
Petra E. Buergisser, Yibin Wang, Christoph Rau, Wen Dun, Jeffrey Chukwuneke, Emily J. Tsai, Gaston Jean-Louis, Christos Tzimas, Katherine S. Lee
Publikováno v:
JCI insight. 5
Right ventricular dysfunction is highly prevalent across cardiopulmonary diseases and independently predicts death in both heart failure (HF) and pulmonary hypertension (PH). Progression towards right ventricular failure (RVF) can occur in spite of o
Publikováno v:
The FASEB Journal. 34:1-1