Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christos Skrekas"'
Autor:
Jan Zrimec, Xiaozhi Fu, Azam Sheikh Muhammad, Christos Skrekas, Vykintas Jauniskis, Nora K. Speicher, Christoph S. Börlin, Vilhelm Verendel, Morteza Haghir Chehreghani, Devdatt Dubhashi, Verena Siewers, Florian David, Jens Nielsen, Aleksej Zelezniak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Design of de novo synthetic regulatory DNA is a promising avenue to control gene expression in biotechnology and medicine. Here the authors present EspressionGAN, a generative adversarial network that uses genomic and transcriptomic data to generate
Externí odkaz:
https://doaj.org/article/bb9aa1851b914f7090a2adb235e06f6d
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0239882 (2020)
Alkane-based biofuels are desirable to produce at a commercial scale as these have properties similar to current petroleum-derived transportation fuels. Rationally engineering microorganisms to produce a desirable compound, such as alkanes, is, howev
Externí odkaz:
https://doaj.org/article/234e8c092c4d4836987719c2cc52a18d
Autor:
Christos Skrekas, Johan Gustafsson, Florian David, Maximilian Otto, Verena Siewers, Michael Gossing
Publikováno v:
ACS Synthetic Biology
Standardisation of genetic parts has become a topic of increasing interest over the last decades. The promise of simplifying molecular cloning procedures, while at the same time making them more predictable and reproducible has led to the design of s
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2513
Metabolic engineering of microbial cells is the discipline of optimizing microbial metabolism to enable and improve the production of target molecules ranging from biofuels and chemical building blocks to high-value pharmaceuticals. The advances in g
Publikováno v:
Methods in Molecular Biology ISBN: 9781071623985
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c0a30fc7cc329a1db957eb4beb7c25
https://doi.org/10.1007/978-1-0716-2399-2_4
https://doi.org/10.1007/978-1-0716-2399-2_4
Autor:
Aleksej Zelezniak, Jens Nielsen, Vykintas Jauniskis, Morteza Haghir Chehreghani, Vilhelm Verendel, Devdatt Dubhashi, C. S. Boerlin, Azam Sheikh Muhammad, X. Fu, Jan Zrimec, N. Speicher, Christos Skrekas, Florian David, Verena Siewers
In order to control gene expression, regulatory DNA variants are commonly designed using random synthetic approaches with mutagenesis and screening. This however limits the size of the designed DNA to span merely a part of a single regulatory region,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0ba108202404de12443b5a195f0bc22
https://doi.org/10.1101/2021.07.15.452480
https://doi.org/10.1101/2021.07.15.452480
Alkane-based biofuels are desirable to produce at a commercial scale as these have properties similar to our current petroleum-derived transportation fuels. Rationally engineering microorganisms to produce a desirable compound, such as alkanes, is, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5800cd4b3cb6cb33c6f9423a84d1ffc8
https://doi.org/10.1101/2020.09.16.299479
https://doi.org/10.1101/2020.09.16.299479
Autor:
Alex Hedin, Jens Nielsen, Benjamin Sanchez, Christos Skrekas, Raphael Ferreira, Florian David, Verena Siewers
Publikováno v:
Ferreira, R, Skrekas, C, Hedin, A, Sánchez, B J, Siewers, V, Nielsen, J & David, F 2019, ' Model-Assisted Fine-Tuning of Central Carbon Metabolism in Yeast through dCas9-Based Regulation ', ACS Synthetic Biology, vol. 8, pp. 2457-2463 . https://doi.org/10.1021/acssynbio.9b00258
ACS Synthetic Biology
ACS Synthetic Biology
Engineering Saccharomyces cerevisiae for industrial-scale production of valuable chemicals involves extensive modulation of its metabolism. Here, we identified novel gene expression fine-tuning set-ups to enhance endogenous metabolic fluxes toward in
Publikováno v:
ACS synthetic biology. 7(1)
Clustered regularly interspaced short palindromic repeats (CRISPR) technology has greatly accelerated the field of strain engineering. However, insufficient efforts have been made toward developing robust multiplexing tools in Saccharomyces cerevisia