Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christos Kiourtis"'
Autor:
Christos Kiourtis, Ania Wilczynska, Colin Nixon, William Clark, Stephanie May, Thomas G. Bird
Publikováno v:
Biology Open, Vol 10, Iss 9 (2021)
Mice are a widely used pre-clinical model system in large part due to their potential for genetic manipulation. The ability to manipulate gene expression in specific cells under temporal control is a powerful experimental tool. The liver is central t
Externí odkaz:
https://doaj.org/article/20782b67b1f6464d846e370308cf1da4
Autor:
Stephanie May, Miryam Müller, Callum R. Livingstone, George L. Skalka, Peter J. Walsh, Colin Nixon, Ann Hedley, Robin Shaw, William Clark, Johan Vande Voorde, Leah Officer-Jones, Fiona Ballantyne, Ian R. Powley, Thomas M. Drake, Christos Kiourtis, Andrew Keith, Ana Sofia Rocha, Saverio Tardito, David Sumpton, John Le Quesne, Martin Bushell, Owen J. Sansom, Thomas G. Bird
Publikováno v:
May, S, Müller, M, Livingstone, C R, Skalka, G L, Walsh, P J, Nixon, C, Hedley, A, Shaw, R, Clark, W, Voorde, J V, Officer-Jones, L, Ballantyne, F, Powley, I R, Drake, T M, Kiourtis, C, Keith, A, Rocha, A S, Tardito, S, Sumpton, D, Le Quesne, J, Bushell, M, Sansom, O J & Bird, T G 2023, ' Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.01.009
BACKGROUND & AIMS: Mouse models of lineage tracing have helped to describe the important subpopulations of hepatocytes responsible for liver regeneration. However, conflicting results have been obtained from different models. Here we aimed to reconci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29bf65eb2e4c68bc848e46e670c91a9
https://doi.org/10.1016/j.jhep.2023.01.009
https://doi.org/10.1016/j.jhep.2023.01.009
Autor:
Lucy M.V. Gee, Ben Barron-Millar, Jack Leslie, Claire Richardson, Marco Y.W. Zaki, Saimir Luli, Rachel A. Burgoyne, Rainie I.T. Cameron, Graham R. Smith, John G. Brain, Barbara Innes, Laura Jopson, Jessica K. Dyson, Katherine R.C. McKay, Alexandros Pechlivanis, Elaine Holmes, Rolando Berlinguer-Palmini, Stella Victorelli, George F. Mells, Richard N. Sandford, Jeremy Palmer, John A. Kirby, Christos Kiourtis, Joao Mokochinski, Zoe Hall, Thomas G. Bird, Lee A. Borthwick, Christopher M. Morris, Peter S. Hanson, Diana Jurk, Elizabeth A. Stoll, Fiona E.N. LeBeau, David E.J. Jones, Fiona Oakley
Publikováno v:
Gee, L M V, Barron-Millar, B, Leslie, J, Richardson, C, Zaki, M Y W, Luli, S, Burgoyne, R, Cameron, R I T, Smith, G R, Brain, J G, Innes, B, Jopson, L, Dyson, J K, McKay, K R C, Pechlivanis, A, Holmes, E, Berlinguer-Palmini, R, Victorelli, S, Mells, G F, Sandford, R N, Palmer, J, Kirby, J, Kiourtis, C, Mokochinski, J, Hall, Z, Bird, T G, Borthwick, L A, Morris, C, Hanson, P, Jurk, D, Stoll, E, LeBeau, F, Jones, D & Oakley, F 2022, ' Anti-Cholestatic therapy with Obeticholic Acid improves short term memory in bile duct ligated mice ', The American Journal of Pathology . https://doi.org/10.1016/j.ajpath.2022.09.005
Patients with cholestatic liver disease, including those with primary biliary cholangitis, can experience symptoms of impaired cognition or brain fog. This phenomenon remains unexplained and is currently untreatable. Bile duct ligation (BDL) is an es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d70f37cc3ec34fd9fc440f82313fc
Autor:
Robin M. Shaw, Karen H. Vousden, Timothy J. Humpton, Thomas G. Bird, William C. Clark, Ann Hedley, Christos Kiourtis, Holly Hall, Colin Nixon, Karen Blyth
Publikováno v:
Humpton, T J, Hall, H, Kiourtis, C, Nixon, C, Clark, W, Hedley, A, Shaw, R, Bird, T G, Blyth, K & Vousden, K H 2021, ' p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 ', Cell Death and Differentiation . https://doi.org/10.1038/s41418-021-00871-3
The p53 transcription factor coordinates wide-ranging responses to stress that contribute to its function as a tumour suppressor. The responses to p53 induction are complex and range from mediating the elimination of stressed or damaged cells to prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9453106a998005b6923a497619a33a85
https://doi.org/10.1038/s41418-021-00871-3
https://doi.org/10.1038/s41418-021-00871-3
Autor:
Miryam Müller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Jack Leslie, Joep Sprangers, Gaurav Malviya, Agata Mrowinska, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Anastasia Georgakopoulou, Colin Nixon, William Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Lewis, Helen L. Reeves, Derek A. Mann, Karen Blyth, Markus H. Heim, Leo M. Carlin, Owen J. Sansom, Crispin Miller, Thomas G. Bird
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer related mortality worldwide. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78119737c41eaeb832b377a7ed788d9
https://doi.org/10.21203/rs.3.rs-1638504/v1
https://doi.org/10.21203/rs.3.rs-1638504/v1
Autor:
Timothy J. Humpton, Andreas K. Hock, Christos Kiourtis, Marco De Donatis, Frédéric Fercoq, Colin Nixon, Sheila Bryson, Douglas Strathdee, Leo M. Carlin, Thomas G. Bird, Karen Blyth, Karen H. Vousden
Genetically encoded probes are widely used to visualize cellular processes in vitro and in vivo. Although effective in cultured cells, fluorescent protein tags and reporters are suboptimal in vivo because of poor tissue penetration and high backgroun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6993bf6e4b0bc8791e2d6c71468377aa
https://eprints.gla.ac.uk/265328/1/265328.pdf
https://eprints.gla.ac.uk/265328/1/265328.pdf
Autor:
Christos Kiourtis, Thomas Bird
Publikováno v:
Cellular Senescence in Disease ISBN: 9780128225141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8dff62a388b96005e12cd0194a3910d
https://doi.org/10.1016/b978-0-12-822514-1.00004-3
https://doi.org/10.1016/b978-0-12-822514-1.00004-3
Autor:
Shariq Abid, Serge Adnot, Alvar Agusti, Delphine Beaulieu, Anil Bhushan, Thomas G. Bird, Emmanuelle Born, Marielle Breau, Alexander F. Chin, Jennifer H. Elisseeff, Zulrahman Erlangga, Konstantinos Evangelou, Rosa Faner, Joshua N. Farr, Eleni Georgakopoulou, Estela González-Gualda, Vassilis G. Gorgoulis, Elise Gray-Gaillard, Jin Han, Fernanda Hernandez-Gonzalez, Amal Houssaini, Michael D. Jensen, Diana Jurk, Goro Katsuumi, Sundeep Khosla, Christos Kiourtis, James L. Kirkland, Marta Kovatcheva, Larissa Lipskaia, Jose Alberto López-Domínguez, David Macías, Elisabeth Marcos, Mate Maus, Anette Melk, Kathleen Meyer, John Michel, Tohru Minamino, Satomi Miwa, David G. Monroe, Daniel Muñoz-Espín, Hui-Ling Ou, Allyson K. Palmer, Nayuta Saito, Roland Schmitt, Jacobo Sellares, Manuel Serrano, Myong-Hee Sung, Tamara Tchkonia, Peter J. Thompson, Thomas von Zglinicki, Tengfei Wan, Peisu Zhang
Publikováno v:
Cellular Senescence in Disease ISBN: 9780128225141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b75ae32a421dd67dc1780eb3c723f4
https://doi.org/10.1016/b978-0-12-822514-1.01002-6
https://doi.org/10.1016/b978-0-12-822514-1.01002-6
Autor:
Christos Kiourtis, Maria Terradas-Terradas, Lucy M. Gee, Ya-Ching Hsieh, Colin Nixon, William Clark, Robin Shaw, Peter S. Hanson, David Sumpton, Gillian Mackay, Stephanie May, Miryam Müller, Arafath K. Najumudeen, Andrew Campbell, Simon T. Barry, Christopher M. Morris, Fiona E. N. LeBeau, Owen J. Sansom, Kristina Kirschner, Fiona Oakley, Thomas G. Bird
Cellular senescence is associated with aging but also impacts various physiological and pathological processes such as embryonic development and wound healing. Factors secreted by senescent cells can affect their microenvironment, including local spr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2017462eefc336f5e042d4ea9ff8df0
https://doi.org/10.21203/rs.3.rs-1133747/v1
https://doi.org/10.21203/rs.3.rs-1133747/v1
Autor:
Ania Wilczynska, Colin Nixon, William C. Clark, Thomas G. Bird, Christos Kiourtis, Stephanie May
Publikováno v:
Biology Open, Vol 10, Iss 9 (2021)
Biology Open
article-version (VoR) Version of Record
Kiourtis, C, Wilczynska, A, Nixon, C, Clark, W, May, S & Bird, T G 2021, ' Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice ', Biology Open . https://doi.org/10.1242/bio.058678
Biology Open
article-version (VoR) Version of Record
Kiourtis, C, Wilczynska, A, Nixon, C, Clark, W, May, S & Bird, T G 2021, ' Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice ', Biology Open . https://doi.org/10.1242/bio.058678
Mice are a widely used pre-clinical model system in large part due to their potential for genetic manipulation. The ability to manipulate gene expression in specific cells under temporal control is a powerful experimental tool. The liver is central t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34132cd11a7d107fc7330c1737a5c8cf
http://bio.biologists.org/content/10/9/bio058678
http://bio.biologists.org/content/10/9/bio058678