Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Christos Gatsogiannis"'
Autor:
Maximilian Rüttermann, Michelle Koci, Pascal Lill, Ermis Dionysios Geladas, Farnusch Kaschani, Björn Udo Klink, Ralf Erdmann, Christos Gatsogiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling and is essential for peroxisome formation. Pex1/Pex6 mutations cause severe peroxisome associated developmental disorders. Despite its pathophysiological im
Externí odkaz:
https://doaj.org/article/aa878446295e45169d12efee2a99ca7a
Autor:
Patrícia A. Gomes, Cristian Bodo, Carlos Nogueras-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana M. Silva, Bárbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Extracellular vesicles (EVs), including small EVs (sEVs) such as exosomes, exhibit great potential for the diagnosis and treatment of brain disorders, representing a valuable tool for precision medicine. The latter demands high-qu
Externí odkaz:
https://doaj.org/article/1b9f0ce8293249e8b5b641bda464ebec
Autor:
Minghao Chen, Daniel Blum, Lena Engelhard, Stefan Raunser, Richard Wagner, Christos Gatsogiannis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The venom of Latrodectus spiders contains seven Latrotoxins (LaTXs), among them α-latrocrustatoxin (LCT) and δ- latroinsectotoxins δ-LIT. LaTXs bind to specific receptors on the surface of neuronal cells and target the molecular exocytosis machine
Externí odkaz:
https://doaj.org/article/665db54f53c6489eba8074903eca63cd
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/956284684c954ad18653de27c4ef4e5a
Autor:
Markus Stabrin, Fabian Schoenfeld, Thorsten Wagner, Sabrina Pospich, Christos Gatsogiannis, Stefan Raunser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
High-throughput single particle cryo-EM, for instance in drug research, requires the automation of the single particle analysis workflow. Here, the authors present TranSPHIRE, a software package that allows the fully-automated, feedback-driven proces
Externí odkaz:
https://doaj.org/article/d60f1db43f614ca5b692b67d9a2a71c0
Autor:
Patrick Günther, Dennis Quentin, Shehryar Ahmad, Kartik Sachar, Christos Gatsogiannis, John C Whitney, Stefan Raunser
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010182 (2022)
The type VI secretion system (T6SS) is a widespread protein export apparatus found in Gram-negative bacteria. The majority of T6SSs deliver toxic effector proteins into competitor bacteria. Yet, the structure, function, and activation of many of thes
Externí odkaz:
https://doaj.org/article/c171fbe095c84be2983b903b51245977
Autor:
Sergej Kudruk, Sharafudheen Pottanam Chali, Anna Livia Linard Matos, Cole Bourque, Clara Dunker, Christos Gatsogiannis, Bart Jan Ravoo, Volker Gerke
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract The transport of membrane impermeable compounds into cells is a prerequisite for the efficient cellular delivery of hydrophilic and amphiphilic compounds and drugs. Transport into the cell's cytosolic compartment should ideally be controllab
Externí odkaz:
https://doaj.org/article/78b828752c804bfda93d46a2fab4da6a
Autor:
Yoshikazu Tanaka, Sanae Kato, Markus Stabrin, Stefan Raunser, Takashi Matsui, Christos Gatsogiannis
Publikováno v:
IUCrJ, Vol 6, Iss 3, Pp 426-437 (2019)
The oxygen transporter of molluscs, hemocyanin, consists of long pearl-necklace-like subunits of several globular domains. The subunits assemble in a complex manner to form cylindrical decamers. Typically, the first six domains of each subunit assemb
Externí odkaz:
https://doaj.org/article/91feb17aee6742bc9e9b3c7aea13e7ae
Autor:
Claudia Antoni, Dennis Quentin, Alexander E Lang, Klaus Aktories, Christos Gatsogiannis, Stefan Raunser
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008530 (2020)
Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high mortality in humans and other mammals. It consists of a membrane translocase, known as protective antigen (PA), that catalyzes the unfolding of its cytotoxic sub
Externí odkaz:
https://doaj.org/article/a52dd63056ea47a8930898189a56eab0
Publikováno v:
eLife, Vol 9 (2020)
The BBSome is a heterooctameric protein complex that plays a central role in primary cilia homeostasis. Its malfunction causes the severe ciliopathy Bardet-Biedl syndrome (BBS). The complex acts as a cargo adapter that recognizes signaling proteins s
Externí odkaz:
https://doaj.org/article/2dff73be151249758c53600b2272457c