Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Christos G Savva"'
Autor:
Deborah H Brotherton, Sarbjit Nijjar, Christos G Savva, Nicholas Dale, Alexander David Cameron
Publikováno v:
eLife, Vol 13 (2024)
Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO2. This is proposed to be mediated through carbamylation of K125. We show that mutating K12
Externí odkaz:
https://doaj.org/article/de3c7cd867ee436496d58ec2c183d51b
Autor:
Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans, Jonathan K Ball, John W R Schwabe, Julian E Sale, Nicholas P J Brindle
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010733 (2022)
Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in develop
Externí odkaz:
https://doaj.org/article/1c450b5c20754a42910056edeab3abf1
Autor:
Jason Murray, Christos G Savva, Byung-Sik Shin, Thomas E Dever, V Ramakrishnan, Israel S Fernández
Publikováno v:
eLife, Vol 5 (2016)
Viral mRNA sequences with a type IV IRES are able to initiate translation without any host initiation factors. Initial recruitment of the small ribosomal subunit as well as two translocation steps before the first peptidyl transfer are essential for
Externí odkaz:
https://doaj.org/article/755af35de2bc4295afa69333a29cf5ba
Autor:
Jessica Huyet, Claire E Naylor, Christos G Savva, Maryse Gibert, Michel R Popoff, Ajit K Basak
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66673 (2013)
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following
Externí odkaz:
https://doaj.org/article/c3f5651218b94a3cb97156e8a284cdec
Autor:
Jakub Gruszczyk, Loic Grandvuillemin, Josephine Lai-Kee-Him, Matteo Paloni, Christos G. Savva, Pierre Germain, Marina Grimaldi, Abdelhay Boulahtouf, Hok-Sau Kwong, Julien Bous, Aurelie Ancelin, Cherine Bechara, Alessandro Barducci, Patrick Balaguer, William Bourguet
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.7010. ⟨10.1038/s41467-022-34773-w⟩
Nature Communications, 2022, 13 (1), pp.7010. ⟨10.1038/s41467-022-34773-w⟩
SummaryLiving organisms have developed protein sensors helping them to adapt to their environment1. The aryl hydrocarbon receptor (AHR) is an emblematic member of this class of proteins, and a ligand-dependent transcription factor that mediates a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16c0395b2827ff630958bdfe6419568
https://doi.org/10.1038/s41467-022-34773-w
https://doi.org/10.1038/s41467-022-34773-w
Autor:
John W.R. Schwabe, Christopher J. Millard, Christos G. Savva, Timothy J. Ragan, Louise Fairall
Publikováno v:
Nucleic Acids Research
Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have diverse modes of action determined by associated factors in the distinct complexes. The deacetylase module
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e835dc403e3d543de110c2a0a109236b
https://doi.org/10.1093/nar/gkaa1121
https://doi.org/10.1093/nar/gkaa1121
Autor:
Vlad-Stefan Raducanu, Muhammad Tehseen, Nekane Merino, Afnan Shirbini, Francisco J. Blanco, Alfredo De Biasio, Fahad Rashid, Manal S. Zaher, Claudia Lancey, Samir M. Hamdan, Timothy J. Ragan, Christos G. Savva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520ed1b2412fe299f96b7d178fbcc23b
http://link.springer.com/article/10.1038/s41467-020-14898-6
http://link.springer.com/article/10.1038/s41467-020-14898-6
Autor:
Micha B. A. Kunze, Nobuhiro Morone, Naomi Robertson, Timothy J. Ragan, Mingxuan Wu, Yun Song, Andrew G. Jamieson, Lisbeth Dagil, Almutasem Saleh, Christos G. Savva, D. Flemming Hansen, Philip A. Cole, John W.R. Schwabe, Louise Fairall
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2699-2711.e8 (2020)
Cell Reports
Cell Reports
Summary The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddab0f08ba86830043c6759c9896a14
http://www.sciencedirect.com/science/article/pii/S221112472030125X
http://www.sciencedirect.com/science/article/pii/S221112472030125X
Autor:
Deborah H, Brotherton, Christos G, Savva, Timothy J, Ragan, Nicholas, Dale, Alexander D, Cameron
Publikováno v:
Structure (London, England : 1993). 30(5)
Connexins form large-pore channels that function either as dodecameric gap junctions or hexameric hemichannels to allow the regulated movement of small molecules and ions across cell membranes. Opening or closing of the channels is controlled by a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09c962a2650b6581eb89fc92b10fc61e
https://pubmed.ncbi.nlm.nih.gov/35276081
https://pubmed.ncbi.nlm.nih.gov/35276081
Autor:
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, Julian E Sale, Nicholas PJ Brindle
Emerging SARS CoV-2 variants are creating major challenges in the ongoing Covid-19 pandemic. Predicting CoV-2 mutations that increase transmissibility or immune evasion would be extremely valuable in development of broad-acting therapeutics and vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc56e998f9cb0ce644b073a2815e766
https://doi.org/10.1101/2021.12.23.473975
https://doi.org/10.1101/2021.12.23.473975
