Zobrazeno 1 - 10 of 178 pro vyhledávání: '"Christos, Reppas"'
1
Akademický článek
The effect of propranolol on gastrointestinal motility and permeability in patients with cirrhosis and significant portal hypertension
Autor: Elias Xirouchakis, Hariklia Kranidioti, Emilia Hadziyanni, Anastasia Kourikou, Christos Reppas, Maria Vertzoni, Nikolaos Papadopoulos, Melanie Deutsch, George Papatheodoridis, Spilios Manolakopoulos
Publikováno v: BMC Gastroenterology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Patients with cirrhosis and portal hypertension may have alterations in intestinal barrier resulting in increased susceptibility for infections. We investigated the effect of propranolol in gastrointestinal motility, permeability
Externí odkaz: https://doaj.org/article/a019e05b2fb3463d8d299c093a1604db
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2
Akademický článek
Exploring the impact of Crohn’s disease on the intragastric environment of fasted adults
Autor: Maria Vertzoni, Christina Koulouri, Androniki Poulou, Konstantinos Goumas, Christos Reppas
Publikováno v: ADMET and DMPK, Vol 8, Iss 2, Pp 122-128 (2020)
We explored the potential impact of Crohn’s disease on the intragastric environment of fasted adults with a view to potential effects on intragastric performance of orally administered drugs in the fasted state. Data were collected from 15 healthy
Externí odkaz: https://doaj.org/article/82447ad3f6644bbc87f6a19046bbca37
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6
In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults
Autor: Ronald Schilderink, Maria Vertzoni, Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Christos Reppas, Mans Minekus, Mark McAllister
Publikováno v: Journal of Pharmaceutical Sciences. 111:197-205
We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were performed wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51bd1e6a35d423f74f4f489537dcfe5
https://doi.org/10.1016/j.xphs.2021.10.010
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9
Akademický článek
On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development
Autor: Patrick J. O’Dwyer, Georgios Imanidis, Karl J. Box, Christos Reppas
Publikováno v: Pharmaceutics, Vol 12, Iss 3, p 272 (2020)
A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole. Th
Externí odkaz: https://doaj.org/article/654759486b4e406f93bd46e1917a97b0
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10
Akademický článek
Increasing the biorelevance of simulated intestinal fluids for better predictions of drug equilibrium solubility in the fasted upper small intestine
Autor: Nikolaos Koumandrakis, Maria Vertzoni, Christos Reppas
Publikováno v: ADMET and DMPK, Vol 2, Iss 2, Pp 71-79 (2014)
To date the importance of luminal species other than bile salts and phosphatidylcholine on drug equilibrium solubility in the fasted upper small intestine has not been evaluated. In this communication the importance of fatty acids, cholesterol, and p
Externí odkaz: https://doaj.org/article/ac0c8861518e460281cc4fd47be33685
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