Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Christos, Chinopoulos"'
Autor:
Arpád Dobolyi, Melinda Cservenák, Attila G. Bagó, Chun Chen, Anna Stepanova, Krisztina Paal, Jeonghyoun Lee, Miklós Palkovits, Gavin Hudson, Christos Chinopoulos
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The astrocyte-to-neuron lactate shuttle model entails that, upon glutamatergic neurotransmission, glycolytically derived pyruvate in astrocytes is mainly converted to lactate instead of being entirely catabolized in mitochondria. The mechani
Externí odkaz:
https://doaj.org/article/d47b2b71158e40009605bff1a4f8f169
Autor:
Dora Ravasz, David Bui, Sara Nazarian, Gergely Pallag, Noemi Karnok, Jennie Roberts, Bryan P. Marzullo, Daniel A. Tennant, Bennett Greenwood, Alex Kitayev, Collin Hill, Timea Komlódi, Carolina Doerrier, Kristyna Cunatova, Erika Fernandez-Vizarra, Erich Gnaiger, Michael A. Kiebish, Alexandra Raska, Krasimir Kolev, Bence Czumbel, Niven R. Narain, Thomas N. Seyfried, Christos Chinopoulos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced compounds in the mitochondrial matrix which impedes dehydrogenases. By simultaneously measuring oxygen concentration, NADH autofluorescence, mitochondrial mem
Externí odkaz:
https://doaj.org/article/453486a76e924fb8b9b5af5d51ebc216
Autor:
Judit Doczi, Noemi Karnok, David Bui, Victoria Azarov, Gergely Pallag, Sara Nazarian, Bence Czumbel, Thomas N. Seyfried, Christos Chinopoulos
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Alterations in metabolism are a hallmark of cancer. It is unclear if oxidative phosphorylation (OXPHOS) is necessary for tumour cell survival. In this study, we investigated the effects of severe hypoxia, site-specific inhibition of respirat
Externí odkaz:
https://doaj.org/article/6eaf808dbbbf4c99a010823d320edd36
Autor:
Thomas N. Seyfried, Gabriel Arismendi-Morillo, Giulio Zuccoli, Derek C. Lee, Tomas Duraj, Ahmed M. Elsakka, Joseph C. Maroon, Purna Mukherjee, Linh Ta, Laura Shelton, Dominic D'Agostino, Michael Kiebish, Christos Chinopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for the synthesis of biomass and energy (ATP) regardless of the cellular or genetic heterogeneity seen within the tumor. The transition from respiration to fermentat
Externí odkaz:
https://doaj.org/article/74eb8cee777944af80425d23672b01c8
Autor:
Gergő Horváth, Gergely Sváb, Tímea Komlódi, Dora Ravasz, Gergely Kacsó, Judit Doczi, Christos Chinopoulos, Attila Ambrus, László Tretter
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1487 (2022)
α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer’s disease. The ai
Externí odkaz:
https://doaj.org/article/e63f5b161a524c698f8f6f43744d2db7
Autor:
Christos Chinopoulos
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
A metabolic hallmark of many cancers is the increase in glucose consumption coupled to excessive lactate production. Mindful that L-lactate originates only from pyruvate, the question arises as to how can this be sustained in those tissues where pyru
Externí odkaz:
https://doaj.org/article/6ec5e2f403c0453ea2a8529f2d9ccd36
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101761- (2020)
ATP is required for mammalian cells to remain viable and to perform genetically programmed functions. Maintenance of the ΔG′ATP hydrolysis of −56 kJ/mole is the endpoint of both genetic and metabolic processes required for life. Various anomalie
Externí odkaz:
https://doaj.org/article/fad3fdead8c54fbbb33120afded51644
Autor:
Thomas N. Seyfried, Purna Mukherjee, Mehmet S. Iyikesici, Abdul Slocum, Miriam Kalamian, Jean-Pierre Spinosa, Christos Chinopoulos
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Breast cancer remains as a significant cause of morbidity and mortality in women. Ultrastructural and biochemical evidence from breast biopsy tissue and cancer cells shows mitochondrial abnormalities that are incompatible with energy production throu
Externí odkaz:
https://doaj.org/article/c7068ac8e45e4026879ae5d61ece4752
Publikováno v:
Metabolites, Vol 11, Iss 9, p 572 (2021)
A theory that can best explain the facts of a phenomenon is more likely to advance knowledge than a theory that is less able to explain the facts. Cancer is generally considered a genetic disease based on the somatic mutation theory (SMT) where mutat
Externí odkaz:
https://doaj.org/article/f4b6d0bea2d348fc9274ff9254c17995
Publikováno v:
ASN Neuro, Vol 10 (2018)
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit mitochondrial abnormalities incompatible with energy production through oxidative
Externí odkaz:
https://doaj.org/article/e5dbce9c6bd94ab49c8610504032367a