Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Christopher Y, Park"'
Autor:
Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental tra
Externí odkaz:
https://doaj.org/article/0d64cab140164afb8b8aaf26ab3db645
Autor:
Adalberto Claudio Quiros, Nicolas Coudray, Anna Yeaton, Xinyu Yang, Bojing Liu, Hortense Le, Luis Chiriboga, Afreen Karimkhan, Navneet Narula, David A. Moore, Christopher Y. Park, Harvey Pass, Andre L. Moreira, John Le Quesne, Aristotelis Tsirigos, Ke Yuan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Cancer diagnosis and management depend upon the extraction of complex information from microscopy images by pathologists, which requires time-consuming expert interpretation prone to human bias. Supervised deep learning approaches have prove
Externí odkaz:
https://doaj.org/article/24019f1068da441492cffc896558e017
Autor:
Mónica del Rey González, Sohini Chakraborty, Jesús María Hernández-Sánchez, María Diez Campelo, Christopher Y. Park, Jesús María Hernández Rivas
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Treatment with the hypomethylating agent 5-azacytidine (AZA) increases survival in high-risk (HR) myelodysplastic syndrome (MDS) patients, but predicting patient response and overall survival remains challenging. To address these issues, we analyzed
Externí odkaz:
https://doaj.org/article/c7fb6c7685b74917942b55da558c1fcc
Autor:
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effe
Externí odkaz:
https://doaj.org/article/07013829e0064a6b9da30cd661ecddb5
Autor:
Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr
Externí odkaz:
https://doaj.org/article/6b54770221c34086b376c539aef6277a
Autor:
Kirsty Sawicka, Caryn R Hale, Christopher Y Park, John J Fak, Jodi E Gresack, Sarah J Van Driesche, Jin Joo Kang, Jennifer C Darnell, Robert B Darnell
Publikováno v:
eLife, Vol 8 (2019)
Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP function varies across brain regions and cell types and how this contributes to disease patho
Externí odkaz:
https://doaj.org/article/9fff226c6aef43b985f7c22c186b7dd5
Autor:
Stephen S. Chung, Christopher Y. Park
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2572-2578 (2017)
Abstract: The aging hematopoietic system undergoes numerous changes, including reduced production of red blood cells and lymphocytes as well as a relative increase in the production of myeloid cells. Emerging evidence indicates that many of these cha
Externí odkaz:
https://doaj.org/article/1da26e26f3cd48a99d2642481d538639
Publikováno v:
Current Treatment Options in Oncology. 23:1522-1534
Autor:
Omar Abdel-Wahab, Tanja A. Gruber, Neal Rosen, Jean-Francois Emile, Ahmet Dogan, Zahir Amoura, Christopher Y. Park, Barry S. Taylor, Filip Janku, José Baselga, David M. Hyman, David B. Solit, Jean Donadieu, Sebastien Héritier, Jared Block, Omotayo Fasan, Samuel R. Briggs, Siraj M. Ali, Jeffrey S. Ross, Vincent A. Miller, Philip J. Stephens, William A. Gahl, Mario Lacouture, Juvianee Estrada-Veras, David W. Ellison, James D. Dalton, Chezi Ganzel, Joy Nakitandwe, Paul Zappile, Adriana Heguy, Olga Aminova, Igor Dolgalev, Brooke Sylvester, Michael P. Walsh, Patrick Campbell, Jean-Baptiste Micol, Yijun Gao, Stanley Chun-Wei Lee, Fleur Cohen-Aubart, Eunhee Kim, John Choi, Zhaoming Wang, Sameer A. Parikh, Jing Ma, Zhan Yao, Julien Haroche, Benjamin H. Durham, Eli L. Diamond
Supplementary Figure 1. Somatic mutations detected in histiocytic neoplasms. Supplementary Figure 2. Frequencies of known activating kinase mutations in histiocytic neoplasms. Supplementary Figure 3. ARAF mutations and variants of unknown significanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0075033853c222afd5d85bcdeb5cc286
https://doi.org/10.1158/2159-8290.22530029.v1
https://doi.org/10.1158/2159-8290.22530029.v1
Autor:
Ravindra Majeti, Irving L. Weissman, Christopher Y. Park, Feifei Zhao, Rachel Weissman-Tsukamoto, Max Jan, Chad Tang, Ash A. Alizadeh, Mark P. Chao
Supplementary Table Legends 1-3, Methods, References from Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a89092c19ebc5edbf0d53cb1c878d8
https://doi.org/10.1158/0008-5472.22391199
https://doi.org/10.1158/0008-5472.22391199