Zobrazeno 1 - 1
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pro vyhledávání: '"Christopher X. Sheng"'
Autor:
Luciano Mueller, G. C. Rovnyak, Sarah C. Traeger, Henry Shen, Cornelius Lyndon A M, Steven Sheriff, Marco M. Gottardis, Robert M. Borzilleri, Marie Ortega-Nanos, David K. Williams, Frances Y. Lee, Donald Crews, Robert A. Wild, Kyoung S. Kim, Louis J. Lombardo, James S. Ryder, Deborah L. Roussell, Zheng Yang, Robert J. Schmidt, Roberta Batorsky, Patricia A. McDonnell, Andrew T. Pudzianowski, Christopher X. Sheng, Songfeng Lu, John A. Newitt, Rajeev S. Bhide, Gretchen M. Schroeder
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one