Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Christopher Willits"'
1
Akademický článek
Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
Autor: Ken Flanagan, Kent Fitzgerald, Jeanne Baker, Karin Regnstrom, Shyra Gardai, Frederique Bard, Simonetta Mocci, Pui Seto, Monica You, Catherine Larochelle, Alexandre Prat, Samuel Chow, Lauri Li, Chris Vandevert, Wagner Zago, Carlos Lorenzana, Christopher Nishioka, Jennifer Hoffman, Raquel Botelho, Christopher Willits, Kevin Tanaka, Jennifer Johnston, Ted Yednock
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40443 (2012)
TH17 cells enter tissues to facilitate pathogenic autoimmune responses, including multiple sclerosis (MS). However, the adhesion molecules involved in the unique migratory capacity of TH17 cells, into both inflamed and uninflamed tissues remain uncle
Externí odkaz: https://doaj.org/article/ce9517ea747141bb9e840827a0281c34
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2
Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Autor: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v: Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t
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3
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch
Autor: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
Publikováno v: Journal of medicinal chemistry. 56(13)
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056
https://pubmed.ncbi.nlm.nih.gov/23713656
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4
Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei
Autor: Erich Goldbach, Danielle L. Aubele, Simeon Bowers, Daniel Ness, Marcelle Bergeron, Christopher Willits, Andrew J. Olaharski, George Tonn, Kent Fitzgerald
Publikováno v: Toxicology and applied pharmacology. 269(1)
Polo like kinase 2 (PLK2) phosphorylates α-synuclein and is considered a putative therapeutic target for Parkinson's disease. Several lines of evidence indicate that PLK2 is involved with proper centriole duplication and cell cycle regulation, inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b5bd6aa31cd9eb4f7cf6fdabcdae0b
https://pubmed.ncbi.nlm.nih.gov/23466428
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5
Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies
Autor: Angie Wadsworth, Grace Kwong, Elizabeth F. Brigham, Rampurna Gullapalli, Kevin P. Quinn, Erich Goldbach, Bhushan Samant, Angelina Wong, Christopher Willits
Publikováno v: Drug delivery. 19(5)
Hydrophilic, non-aqueous solvents are frequently used to solubilize poorly water soluble compounds for use in ALZET® osmotic pumps used during the discovery and preclinical stages. Though these solvents exhibit the potential to solubilize several po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf8b406e8f756498744f29abc0a056f
https://pubmed.ncbi.nlm.nih.gov/22656673
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7
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS
Autor: Lauri Li, Carlos Lorenzana, Ken Flanagan, Alexandre Prat, Simonetta Mocci, Raquel Botelho, Christopher Nishioka, Frederique Bard, Jennifer Hoffman, Kent Fitzgerald, Shyra J. Gardai, Jeanne Baker, Karin Regnstrom, Christopher Willits, Ted Yednock, Pui Seto, Monica You, Chris Vandevert, Catherine Larochelle, Jennifer Johnston, Samuel Chow, Wagner Zago, Kevin Tanaka
Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40443 (2012)
TH17 cells enter tissues to facilitate pathogenic autoimmune responses, including multiple sclerosis (MS). However, the adhesion molecules involved in the unique migratory capacity of TH17 cells, into both inflamed and uninflamed tissues remain uncle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eef2665c296afb646678f72ef150da1
https://doi.org/10.1371/journal.pone.0040443
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