Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Christopher W. Woods"'
Autor:
Josh G. Chenoweth, Joost Brandsma, Deborah A. Striegel, Pavol Genzor, Elizabeth Chiyka, Paul W. Blair, Subramaniam Krishnan, Elliot Dogbe, Isaac Boakye, Gary B. Fogel, Ephraim L. Tsalik, Christopher W. Woods, Alex Owusu-Ofori, Chris Oppong, George Oduro, Te Vantha, Andrew G. Letizia, Charmagne G. Beckett, Kevin L. Schully, Danielle V. Clark
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precis
Externí odkaz:
https://doaj.org/article/c20dbc2d922941d3a99c931cb0e51535
Autor:
Klaus Schughart, Amber M. Smith, Ephraim L. Tsalik, Stephen C. Threlkeld, Subhashini Sellers, William A. Fischer, Jens Schreiber, Eva Lücke, Markus Cornberg, Jennifer Debarry, Christopher W. Woods, Micah T. McClain, Mark Heise
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInfluenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunop
Externí odkaz:
https://doaj.org/article/da5c678977964239adaadc4fd7821957
Autor:
Emily R. Ko, Megan E. Reller, L. Gayani Tillekeratne, Champica K. Bodinayake, Cameron Miller, Thomas W. Burke, Ricardo Henao, Micah T. McClain, Sunil Suchindran, Bradly Nicholson, Adam Blatt, Elizabeth Petzold, Ephraim L. Tsalik, Ajith Nagahawatte, Vasantha Devasiri, Matthew P. Rubach, Venance P. Maro, Bingileki F. Lwezaula, Wasantha Kodikara-Arachichi, Ruvini Kurukulasooriya, Aruna D. De Silva, Danielle V. Clark, Kevin L. Schully, Deng Madut, J. Stephen Dumler, Cecilia Kato, Renee Galloway, John A. Crump, Geoffrey S. Ginsburg, Timothy D. Minogue, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great promise distinguishing causes of fever. We generated transcriptional data for a 2
Externí odkaz:
https://doaj.org/article/6b810e23001a49d88802db46e9e5c9d3
Autor:
Bryan D. Kraft, Simon Verhulst, Tsung-Po Lai, Bruce A. Sullenger, Yunfei Wang, Wes Rountree, Lingye Chen, Christopher W. Woods, Thomas N. Denny, Abraham Aviv
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte telomere length (TL) is highly variable and shortens with age. Short telomeres may impede TL-dependent T-cell clonal expansion with viral infection. As SARS-CoV-2 infection can induce prolonged and severe T-cell lymphopenia, infected adult
Externí odkaz:
https://doaj.org/article/bd2de7c301b943aabb522de074b07aac
Autor:
A. Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J. Catanzaro, Michael L. Mallory, Melissa D. Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B. Walter, Kevin Wiehe, Robert J. Edwards, David C. Montefiori, Guido Ferrari, Ralph Baric, Derek W. Cain, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassi
Externí odkaz:
https://doaj.org/article/f7c3c671d32d475aacf1c3a48887812f
Autor:
Micah T. McClain, Ilya Zhbannikov, Lisa L. Satterwhite, Ricardo Henao, Nicholas S. Giroux, Shengli Ding, Thomas W. Burke, Ephraim L. Tsalik, Christina Nix, Jorge Prado Balcazar, Elizabeth A. Petzold, Xiling Shen, Christopher W. Woods
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108288- (2024)
Summary: To elucidate host response elements that define impending decompensation during SARS-CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for disease severity and comorbidities at the time of admission. We perfor
Externí odkaz:
https://doaj.org/article/6e07d43e0da14020bb61da0c455e7171
Autor:
James N. Moy, Ariff Mohammed Amin, Claire Chalmers-Watson, Rezwona Chowdhury, Camilla Forssten, Jun Fu, Sarit Ghosh, Jeffrey D. Harris, Simon Kordowich, Yin Li, Wenchi Lin, Stuart Mackay-Thomas, Marc Mickiewicz, Nikesh Patel, Salvador Resino, Tamsin Sevenoaks, Michael A. Tugetman, Jorge Valencia, Roy Vijesurier, Nikki White, Christopher W. Woods, Patrick T. Kennedy, Pablo Ryan
Publikováno v:
Heliyon, Vol 9, Iss 12, Pp e22612- (2023)
Background: The Panbio™ COVID-19 IgG Rapid Test Device (“Panbio™”) detects IgG antibodies against the SARS-CoV-2 spike protein from viral infection or vaccination. Objectives: To determine the diagnostic sensitivity and specificity of the Pan
Externí odkaz:
https://doaj.org/article/e8d932ab6e00475f9af211a755bd3e4d
Autor:
Susanna Naggie, Aaron Milstone, Mario Castro, Sean P. Collins, Seetha Lakshmi, Deverick J. Anderson, Lizbeth Cahuayme-Zuniga, Kisha Batey Turner, Lauren W. Cohen, Judith Currier, Elizabeth Fraulo, Anne Friedland, Jyotsna Garg, Anoop George, Hillary Mulder, Rachel E. Olson, Emily C. O'Brien, Russell L. Rothman, Elizabeth Shenkman, Jack Shostak, Christopher W. Woods, Kevin J. Anstrom, Adrian F. Hernandez
Publikováno v:
International Journal of Infectious Diseases, Vol 129, Iss , Pp 40-48 (2023)
ABSTRACT: Objectives: To determine whether hydroxychloroquine (HCQ) is safe and effective at preventing COVID-19 infections among health care workers (HCWs). Methods: In a 1: 1 randomized, placebo-controlled, double-blind, parallel-group, superiority
Externí odkaz:
https://doaj.org/article/1b8ea14072a44cb1b9ca525f0f41fbe4
Autor:
Janessa Y.J. Tan, Danielle E. Anderson, Abhay P.S. Rathore, Aled O’Neill, Chinmay Kumar Mantri, Wilfried A.A. Saron, Cheryl Q.E. Lee, Chu Wern Cui, Adrian E.Z. Kang, Randy Foo, Shirin Kalimuddin, Jenny G. Low, Lena Ho, Paul Tambyah, Thomas W. Burke, Christopher W. Woods, Kuan Rong Chan, Jörn Karhausen, Ashley L. St. John
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients who are severely ill, and the pathophysiology of disease is thought to be immune mediated. Mast cells (MCs) are polyfunctional immune cells present in the airways, whe
Externí odkaz:
https://doaj.org/article/0ded7096dad04c348c5c375637996e23
Autor:
Taylor E. Gin, Elizabeth A. Petzold, Diya M. Uthappa, Coralei E. Neighbors, Anna R. Borough, Craig Gin, Erin Lashnits, Gregory D. Sempowski, Thomas Denny, Dorothee Bienzle, J. Scott Weese, Benjamin J. Callahan, Christopher W. Woods
Publikováno v:
PeerJ, Vol 11, p e16310 (2023)
We collected oral and/or rectal swabs and serum from dogs and cats living in homes with SARS-CoV-2-PCR-positive persons for SARS-CoV-2 PCR and serology testing. Pre-COVID-19 serum samples from dogs and cats were used as negative controls, and samples
Externí odkaz:
https://doaj.org/article/e79d0a2339414bec89fc8256738c1391