Výsledky vyhledávání - "Christopher W. Wood"

Akademický článek

Differential sensing with arrays of de novo designed peptide assemblies

Autor: William M. Dawson, Kathryn L. Shelley, Jordan M. Fletcher, D. Arne Scott, Lucia Lombardi, Guto G. Rhys, Tania J. LaGambina, Ulrike Obst, Antony J. Burton, Jessica A. Cross, George Davies, Freddie J. O. Martin, Francis J. Wiseman, R. Leo Brady, David Tew, Christopher W. Wood, Derek N. Woolfson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and c

Externí odkaz: https://doaj.org/article/a820f403adc549ffa2b3bf2e841354ca

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Akademický článek

Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

Autor: Manickam Gurusaran, Jelle J. Biemans, Christopher W. Wood, Owen R. Davies

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movemen

Externí odkaz: https://doaj.org/article/36e24ef53b0d48e19c8a3773fdffbf45

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Akademický článek

Maintaining and breaking symmetry in homomeric coiled-coil assemblies

Autor: Guto G. Rhys, Christopher W. Wood, Eric J. M. Lang, Adrian J. Mulholland, R. Leo Brady, Andrew R. Thomson, Derek N. Woolfson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design

Externí odkaz: https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f4

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Akademický článek

Mapping multi-dimensional variability in water stress strategies across temperate forests

Autor: Daijun Liu, Adriane Esquivel-Muelbert, Nezha Acil, Julen Astigarraga, Emil Cienciala, Jonas Fridman, Georges Kunstler, Thomas J. Matthews, Paloma Ruiz-Benito, Jonathan P. Sadler, Mart-Jan Schelhaas, Susanne Suvanto, Andrzej Talarczyk, Christopher W. Woodall, Miguel A. Zavala, Chao Zhang, Thomas A. M. Pugh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Increasing water stress is emerging as a global phenomenon, and is anticipated to have a marked impact on forest function. The role of tree functional strategies is pivotal in regulating forest fitness and their ability to cope with water st

Externí odkaz: https://doaj.org/article/c10c02014122488b9e9f5f78d284ebba

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PDBench: evaluating computational methods for protein-sequence design

Autor: Leonardo V Castorina, Rokas Petrenas, Kartic Subr, Christopher W Wood

Publikováno v: Bioinformatics. 39

Summary Ever increasing amounts of protein structure data, combined with advances in machine learning, have led to the rapid proliferation of methods available for protein-sequence design. In order to utilize a design method effectively, it is import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81cc063a2bee154f923faa10f0dcefc9
https://doi.org/10.1093/bioinformatics/btad027

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Generation of Photocaged Nanobodies for Intracellular Applications in an Animal Using Genetic Code Expansion and Computationally Guided Protein Engineering

Autor: Jack M. O'Shea, Angeliki Goutou, Jack Brydon, Cyrus R. Sethna, Christopher W. Wood, Sebastian Greiss

Publikováno v: Shea, J M O, Goutou, A, Brydon, J, Sethna, C R, Wood, C W & Greiss, S 2022, ' Generation of photocaged nanobodies for intracellular applications in an animal using genetic code expansion and computationally guided protein engineering** ', ChemBioChem, vol. 23, no. 16, e202200321 . https://doi.org/10.1002/cbic.202200321

Nanobodies are becoming increasingly popular as tools for manipulating and visualising proteins in vivo. The ability to control nanobody/antigen interactions using light could provide precise spatiotemporal control over protein function. We develop a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f421909a07c43421c21566c182f85955
https://pubmed.ncbi.nlm.nih.gov/35731601

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Akademický článek

Sepsis endotypes identified by host gene expression across global cohorts

Publikováno v: Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)

Abstract Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precis

Externí odkaz: https://doaj.org/article/c20dbc2d922941d3a99c931cb0e51535

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Akademický článek

Dynamics of cytokine and antibody responses in community versus hospital SARS-CoV-2 infections

Autor: Tulika Singh, Andrew N. Macintyre, Thomas W. Burke, Jack Anderson, Elizabeth Petzold, Erica L. Stover, Matthew J. French, Thomas H. Oguin, Todd Demarco, Micah T. McClain, Emily R. Ko, Lawrence P. Park, Thomas Denny, Gregory D. Sempowski, Christopher W. Woods

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionDysregulated host cytokine responses to SARS-CoV-2 infection are a primary cause of progression to severe disease, whereas early neutralizing antibody responses are considered protective. However, there are gaps in understanding the early

Externí odkaz: https://doaj.org/article/9ffe9ce7cc8c4cf79e7c953067047211

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