Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Christopher W. Wood"'
Autor:
William M. Dawson, Kathryn L. Shelley, Jordan M. Fletcher, D. Arne Scott, Lucia Lombardi, Guto G. Rhys, Tania J. LaGambina, Ulrike Obst, Antony J. Burton, Jessica A. Cross, George Davies, Freddie J. O. Martin, Francis J. Wiseman, R. Leo Brady, David Tew, Christopher W. Wood, Derek N. Woolfson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and c
Externí odkaz:
https://doaj.org/article/a820f403adc549ffa2b3bf2e841354ca
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movemen
Externí odkaz:
https://doaj.org/article/36e24ef53b0d48e19c8a3773fdffbf45
Autor:
Guto G. Rhys, Christopher W. Wood, Eric J. M. Lang, Adrian J. Mulholland, R. Leo Brady, Andrew R. Thomson, Derek N. Woolfson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design
Externí odkaz:
https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f4
Autor:
Daijun Liu, Adriane Esquivel-Muelbert, Nezha Acil, Julen Astigarraga, Emil Cienciala, Jonas Fridman, Georges Kunstler, Thomas J. Matthews, Paloma Ruiz-Benito, Jonathan P. Sadler, Mart-Jan Schelhaas, Susanne Suvanto, Andrzej Talarczyk, Christopher W. Woodall, Miguel A. Zavala, Chao Zhang, Thomas A. M. Pugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Increasing water stress is emerging as a global phenomenon, and is anticipated to have a marked impact on forest function. The role of tree functional strategies is pivotal in regulating forest fitness and their ability to cope with water st
Externí odkaz:
https://doaj.org/article/c10c02014122488b9e9f5f78d284ebba
Publikováno v:
Bioinformatics. 39
Summary Ever increasing amounts of protein structure data, combined with advances in machine learning, have led to the rapid proliferation of methods available for protein-sequence design. In order to utilize a design method effectively, it is import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81cc063a2bee154f923faa10f0dcefc9
https://doi.org/10.1093/bioinformatics/btad027
https://doi.org/10.1093/bioinformatics/btad027
Autor:
Jack M. O'Shea, Angeliki Goutou, Jack Brydon, Cyrus R. Sethna, Christopher W. Wood, Sebastian Greiss
Publikováno v:
Shea, J M O, Goutou, A, Brydon, J, Sethna, C R, Wood, C W & Greiss, S 2022, ' Generation of photocaged nanobodies for intracellular applications in an animal using genetic code expansion and computationally guided protein engineering** ', ChemBioChem, vol. 23, no. 16, e202200321 . https://doi.org/10.1002/cbic.202200321
Nanobodies are becoming increasingly popular as tools for manipulating and visualising proteins in vivo. The ability to control nanobody/antigen interactions using light could provide precise spatiotemporal control over protein function. We develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f421909a07c43421c21566c182f85955
https://pubmed.ncbi.nlm.nih.gov/35731601
https://pubmed.ncbi.nlm.nih.gov/35731601
Autor:
Josh G. Chenoweth, Joost Brandsma, Deborah A. Striegel, Pavol Genzor, Elizabeth Chiyka, Paul W. Blair, Subramaniam Krishnan, Elliot Dogbe, Isaac Boakye, Gary B. Fogel, Ephraim L. Tsalik, Christopher W. Woods, Alex Owusu-Ofori, Chris Oppong, George Oduro, Te Vantha, Andrew G. Letizia, Charmagne G. Beckett, Kevin L. Schully, Danielle V. Clark
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precis
Externí odkaz:
https://doaj.org/article/c20dbc2d922941d3a99c931cb0e51535
Publikováno v:
Biophysical Journal. 122:394a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20f447c55c3a935f06bc028f53d92cfe
https://doi.org/10.1016/j.bpj.2022.11.2151
https://doi.org/10.1016/j.bpj.2022.11.2151
Autor:
Christopher W. Wood, Stam Mj
De novo protein design is a rapidly growing field and there are now many interesting and useful examples of designed proteins in the literature. However, most designs could be classed as failures when characterised in the lab, usually as a result of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa4e8a00167294259da4c7dee5ac7bf
https://doi.org/10.1101/2021.04.28.441790
https://doi.org/10.1101/2021.04.28.441790
Publikováno v:
bioRxiv
Nanobodies are becoming increasingly popular as tools for manipulating and visualising proteins in vivo. The ability to control nanobody/antigen interactions using light could provide precise spatiotemporal control over protein function. We develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575263463ed5acb5324cf94e0d018200
https://doi.org/10.1101/2021.04.16.440193
https://doi.org/10.1101/2021.04.16.440193