Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Christopher W. Ward"'
Autor:
Anicca D. Harriot, Tessa Altair Morris, Camilo Vanegas, Jacob Kallenbach, Kaylie Pinto, Humberto C. Joca, Marie-Jo Moutin, Guoli Shi, Jeanine A. Ursitti, Anna Grosberg, Christopher W. Ward
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal muscle contractile function and increases susceptibility to contraction injury. In murine Duchenne muscular dystrophy (mdx), myofibrillar alterations are ab
Externí odkaz:
https://doaj.org/article/a51700562a7c4ab8a3cb96c40aeb52a0
Autor:
Hugo Bibollet, Elton L. Nguyen, Daniel R. Miranda, Christopher W. Ward, Andrew A. Voss, Martin F. Schneider, Erick O. Hernández‐Ochoa
Publikováno v:
Physiological Reports, Vol 11, Iss 9, Pp n/a-n/a (2023)
Abstract In skeletal muscle, CaV1.1 serves as the voltage sensor for both excitation‐contraction coupling (ECC) and L‐type Ca2+ channel activation. We have recently adapted the technique of action potential (AP) voltage clamp (APVC) to monitor th
Externí odkaz:
https://doaj.org/article/936e352654cf477daee58c2bc9bd9210
Autor:
Justin G. Boyer, Jiuzhou Huo, Sarah Han, Julian R. Havens, Vikram Prasad, Brian L. Lin, David A. Kass, Taejeong Song, Sakthivel Sadayappan, Ramzi J. Khairallah, Christopher W. Ward, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Boyer et al. created genetic mouse models of muscular dystrophy in which satellite cells were selectively depleted. The depletion of satellite cells at select times was protective. Myofibers no longer had plasma membrane instability leading to tissue
Externí odkaz:
https://doaj.org/article/05d4e5eb19ab42dd9227ed224828f09d
Autor:
Brian L. Lin, Joseph Y. Shin, William P.D. Jeffreys, Nadan Wang, Clarisse A. Lukban, Megan C. Moorer, Esteban Velarde, Olivia A. Hanselman, Seoyoung Kwon, Suraj Kannan, Ryan C. Riddle, Christopher W. Ward, Steven S. Pullen, Antonio Filareto, David A. Kass
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Gene mutations causing loss of dystrophin result in the severe muscle disease known as Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair, DMD therapy remains largely palliative. Loss of dystrophin destabilizes the sarcolemmal membr
Externí odkaz:
https://doaj.org/article/813207f919bb49adb167f3f08bc8fd59
Autor:
Christian J. Kinney, Andrea O'Neill, Kaila Noland, Weiliang Huang, Joaquin Muriel, Valeriy Lukyanenko, Maureen A. Kane, Christopher W. Ward, Alyssa F. Collier, Joseph A. Roche, John C. McLenithan, Patrick W. Reed, Robert J. Bloch
Publikováno v:
Current Research in Physiology, Vol 4, Iss , Pp 47-59 (2021)
μ-Crystallin, encoded by the CRYM gene, binds the thyroid hormones, T3 and T4. Because T3 and T4 are potent regulators of metabolism and gene expression, and CRYM levels in human skeletal muscle can vary widely, we investigated the effects of overex
Externí odkaz:
https://doaj.org/article/fe77dc97c80848a79bd121d57e3278b7
Autor:
Uma Mahesh R. Avula, Haikel Dridi, Bi-xing Chen, Qi Yuan, Alexander N. Katchman, Steven R. Reiken, Amar D. Desai, Samantha Parsons, Haajra Baksh, Elaine Ma, Parmanand Dasrat, Ruiping Ji, Yejun Lin, Christine Sison, W. Jonathan Lederer, Humberto C. Joca, Christopher W. Ward, Maura Greiser, Andrew R. Marks, Steven O. Marx, Elaine Y. Wan
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, the development of which requires improved understanding of the cellular signaling pathways that facilitate the structural and ele
Externí odkaz:
https://doaj.org/article/b7be647bfebd45409f3562f2a31b359c
Publikováno v:
Frontiers in Rehabilitation Sciences, Vol 2 (2021)
The decline in the mass and function of bone and muscle is an inevitable consequence of healthy aging with early onset and accelerated decline in those with chronic disease. Termed osteo-sarcopenia, this condition predisposes the decreased activity,
Externí odkaz:
https://doaj.org/article/7b176b62b72844769b73344456b1411f
Publikováno v:
Cells, Vol 10, Iss 5, p 1189 (2021)
The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling. The stretching of the myocyte also increases the calcium affin
Externí odkaz:
https://doaj.org/article/f5d296ac36e6474ca7a634b3977f4590
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The class of muscular dystrophies linked to the genetic ablation or mutation of dysferlin, including Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Miyoshi Myopathy (MM), are late-onset degenerative diseases. In lieu of a genetic cure, treatments to
Externí odkaz:
https://doaj.org/article/fcfa4535555e44e8b83da703805ca9ac
Autor:
Hugo Bibollet, Elton L. Nguyen, Daniel R. Miranda, Christopher W. Ward, Andrew A. Voss, Martin F. Schneider, Erick O. Hernández‐Ochoa
Publikováno v:
Physiological Reports. 11