Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Christopher W. Vaughan"'
Autor:
Lyndsey M. Konen, Amanda L. Wright, Gordon A. Royle, Gary P. Morris, Benjamin K. Lau, Patrick W. Seow, Raphael Zinn, Luke T. Milham, Christopher W. Vaughan, Bryce Vissel
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nuc
Externí odkaz:
https://doaj.org/article/b5bc7dc91fc245ddbc739f87f12ef95c
Autor:
Sherelle L. Casey, Vanessa A. Mitchell, Eddy E. Sokolaj, Bryony L. Winters, Christopher W. Vaughan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8649 (2022)
(1) Background: The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), synergistically reduce allodynia in various animal models of neuropathic pain. Unfortunately, THC-containing drugs a
Externí odkaz:
https://doaj.org/article/e3d534e5f8344225a1209868f6098472
Autor:
Joshua S. Wingerd, Christine A. Mozar, Christine A. Ussing, Swetha S. Murali, Yanni K.-Y. Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W. Vaughan, Frank Bosmans, David J. Adams, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Macdonald J. Christie, Lachlan D. Rash
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Voltage-gated sodium (NaV) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new analgesics. Spider venoms are a rich source of peptide modulators useful to study ion chann
Externí odkaz:
https://doaj.org/article/f33655e710d64fada2b711f3a0de8577
Publikováno v:
Medicines, Vol 5, Iss 3, p 67 (2018)
Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current medications have limitations and new approaches are needed, particularly given the current opioid crisis. There is some cli
Externí odkaz:
https://doaj.org/article/01d8e1f658cf4117bd359d50f08a55c0
Publikováno v:
J Neurosci
The midbrain periaqueductal gray (PAG) plays a central role in pain modulation via descending pathways. Opioids and cannabinoids are thought to activate these descending pathways by relieving intrinsic GABAergic inhibition of PAG neurons which projec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c7a44e4e57a2fd08840802984429f7
https://europepmc.org/articles/PMC9581564/
https://europepmc.org/articles/PMC9581564/
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analg
Publikováno v:
Neuropharmacology. 144:115-121
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the p
Autor:
Christopher W. Vaughan, Steven O. Devenish, Jonathon C. Arnold, Bryony L. Winters, Mary Chebib, Lyndsey L. Anderson, Nathan L. Absalom, Iain S. McGregor
Publikováno v:
Neuropharmacology. 182
GABAA and glycine receptors mediate fast synaptic inhibitory neurotransmission. Despite studies showing that activation of cerebral glycine receptors could be a potential strategy in the treatment of epilepsy, few studies have assessed the effects of
Autor:
Luke T. Milham, Raphael Zinn, Gary P. Morris, Amanda L. Wright, Benjamin K. Lau, Bryce Vissel, Patrick W. Seow, Christopher W. Vaughan, Gordon Royle, Lyndsey M. Konen
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Molecular Brain
Molecular Brain
Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nucleic acid
Publikováno v:
Journal of neurochemistryReferences. 152(1)
It is thought that endogenous cannabinoids have a role in the analgesia induced by specific forms of stress. We examined if the role of endogenous cannabinoids is also dependent upon the mode of nociception, and whether this could be altered by drugs