Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Christopher W. Vaughan"'
Autor:
Lyndsey M. Konen, Amanda L. Wright, Gordon A. Royle, Gary P. Morris, Benjamin K. Lau, Patrick W. Seow, Raphael Zinn, Luke T. Milham, Christopher W. Vaughan, Bryce Vissel
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nuc
Externí odkaz:
https://doaj.org/article/b5bc7dc91fc245ddbc739f87f12ef95c
Autor:
Sherelle L. Casey, Vanessa A. Mitchell, Eddy E. Sokolaj, Bryony L. Winters, Christopher W. Vaughan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8649 (2022)
(1) Background: The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), synergistically reduce allodynia in various animal models of neuropathic pain. Unfortunately, THC-containing drugs a
Externí odkaz:
https://doaj.org/article/e3d534e5f8344225a1209868f6098472
Autor:
Joshua S. Wingerd, Christine A. Mozar, Christine A. Ussing, Swetha S. Murali, Yanni K.-Y. Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W. Vaughan, Frank Bosmans, David J. Adams, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Macdonald J. Christie, Lachlan D. Rash
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Voltage-gated sodium (NaV) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new analgesics. Spider venoms are a rich source of peptide modulators useful to study ion chann
Externí odkaz:
https://doaj.org/article/f33655e710d64fada2b711f3a0de8577
Publikováno v:
J Neurosci
The midbrain periaqueductal gray (PAG) plays a central role in pain modulation via descending pathways. Opioids and cannabinoids are thought to activate these descending pathways by relieving intrinsic GABAergic inhibition of PAG neurons which projec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c7a44e4e57a2fd08840802984429f7
https://europepmc.org/articles/PMC9581564/
https://europepmc.org/articles/PMC9581564/
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analg
Publikováno v:
Medicines, Vol 5, Iss 3, p 67 (2018)
Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current medications have limitations and new approaches are needed, particularly given the current opioid crisis. There is some cli
Externí odkaz:
https://doaj.org/article/01d8e1f658cf4117bd359d50f08a55c0
Publikováno v:
Neuropharmacology. 144:115-121
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the p
Autor:
Benjamin K Lau, Christopher W Vaughan
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/9375d4e4bda3444e941bc894f0a03d1d
Autor:
Christopher W. Vaughan, Steven O. Devenish, Jonathon C. Arnold, Bryony L. Winters, Mary Chebib, Lyndsey L. Anderson, Nathan L. Absalom, Iain S. McGregor
Publikováno v:
Neuropharmacology. 182
GABAA and glycine receptors mediate fast synaptic inhibitory neurotransmission. Despite studies showing that activation of cerebral glycine receptors could be a potential strategy in the treatment of epilepsy, few studies have assessed the effects of
Autor:
Luke T. Milham, Raphael Zinn, Gary P. Morris, Amanda L. Wright, Benjamin K. Lau, Bryce Vissel, Patrick W. Seow, Christopher W. Vaughan, Gordon Royle, Lyndsey M. Konen
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Molecular Brain
Molecular Brain
Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nucleic acid