Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher W. Ng"'
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Anthony R. Soltis, Shmulik Motola, Santiago Vernia, Christopher W. Ng, Norman J. Kennedy, Simona Dalin, Bryan J. Matthews, Roger J. Davis, Ernest Fraenkel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Diet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improve health and extend lifespan. In this work, we
Externí odkaz:
https://doaj.org/article/0ab74bf51b5343838089e195486e12c5
Autor:
Keene L. Abbott, Ahmed Ali, Dominick Casalena, Brian T. Do, Raphael Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt, Steffen Renner, Sophie E. Honeder, Michelle Wu, Sze Ham Chan, Tenzin Tseyang, Daniel Greaves, Peggy P. Hsu, Christopher W. Ng, Chelsea J. Zhang, Ali Farsidjani, Iva Monique T. Gramatikov, Nicholas J. Matheson, Caroline A. Lewis, Clary B. Clish, Matthew G. Rees, Jennifer A. Roth, Lesley Mathews Griner, Alexander Muir, Douglas S. Auld, Matthew G. Vander Heiden
SUMMARYA challenge for screening new candidate drugs to treat cancer is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121795f51a2d3bf410bf9d8120ac9c3b
https://doi.org/10.1101/2023.02.25.529972
https://doi.org/10.1101/2023.02.25.529972
Autor:
Jiang Chen, Anna M. Westermark, Lewis C. Cantley, Rakesh K. Jain, Brendan Prideaux, John M. Asara, Clary B. Clish, David P. Kodack, Neal I. Lindeman, Christopher W. Ng, Gino B. Ferraro, Ivy X. Chen, Costas A. Lyssiotis, Keene L. Abbott, Ahmed Ali, Jens Nielsen, Zohreh Amoozgar, Dai Fukumura, Raphael Ferreira, Dan G. Duda, Mark Duquette, David E. Housman, Jessica M. Possada, Véronique Dartois, Kamila Naxerova, Shawn M. Davidson, Xin Jin, Matthew G. Vander Heiden, Sylvie Roberge, Todd R. Golub, Amy Deik, Christopher R. Chin, Divya Bezwada, Elena F. Brachtel, Alba Luengo, Landry Blanc
Publikováno v:
Nature Cancer. 2:414-428
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability c
Autor:
Ferah Yildirim, Ernest Fraenkel, Jocelyne Caboche, Peter Vanhoutte, Victoria Stivanello, Siobhan K. Rigby, Tobias Ehrenberger, Anthony R. Soltis, Christopher W. Ng, Vincent Kappes, Theresa A. Gipson, David E. Housman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201908113. ⟨10.1073/pnas.1908113116⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201908113. ⟨10.1073/pnas.1908113116⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Huntington’s disease (HD) is a chronic neurodegenerative disorder characterized by a late clinical onset despite ubiquitous expression of the mutant Huntingtin gene ( HTT ) from birth. Transcriptional dysregulation is a pivotal feature of HD. Yet,
Autor:
Dai Fukumura, Anna M. Westermark, Alba Luengo, Landry Blanc, Matthew G. Vander Heiden, Brendan Prideaux, Kamila Naxerova, Keene L. Abbott, Christopher W. Ng, Rakesh K. Jain, Véronique Dartois, Raphael Ferreira, Clary B. Clish, Shawn M. Davidson, Xin Jin, Ahmed Ali, Jessica M. Posada, Amy Deik, Ivy X. Chen, Zohreh Amoozgar, Divya Bezwada, Gino B. Ferraro
Publikováno v:
Neuro Oncol
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability c
Autor:
Lewis C. Cantley, Shawn M. Davidson, Landry Blanc, Gino B. Ferraro, Costas A. Lyssiotis, Xin Jin, Ahmed Ali, John M. Asara, Divya Bezwada, Clary B. Clish, Véronique Dartois, Rakesh K. Jain, Sylvie Roberge, Kamila Naxerova, Christopher R. Chin, Jiang Chen, Brendan Prideaux, David P. Kodack, Dai Fukumura, Anna M. Westermark, Todd R. Golub, Alba Luengo, Keene L. Abbott, Christopher W. Ng, Amy Deik, Matthew G. Vander Heiden, Raphael Ferreira, Mark Duquette, Dan G. Duda, Jessica M. Possada, Ivy X. Chen, Zohreh Amoozgar
Publikováno v:
Neuro-oncology Advances
Brain metastases are refractory to therapies that otherwise control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the unique brain microenvironment contributes to this therapy resistance. Nutrie
Autor:
Rakesh K. Jain, Neal I. Lindeman, Raphael Ferreira, Christopher R. Chin, Clary B. Clish, John M. Asara, Gino B. Ferraro, Keene L. Abbott, Costas A. Lyssiotis, Jessica M. Posada, Alba Luengo, Landry Blanc, Amy Deik, Mark Duquette, Véronique Dartois, Kamila Naxerova, Divya Bezwada, Brendan Prideaux, Shawn M. Davidson, Todd R. Golub, Matthew G. Vander Heiden, David P. Kodack, Ahmed Ali, Dai Fukumura, Elena F. Brachtel, Ivy X. Chen, Xin Jin, Anna M. Westermark, Christopher W. Ng, Dan G. Duda, Zohreh Amoozgar, Sylvie Roberge, Lewis C. Cantley, Jiang Chen, David E. Housman, Jens Nielsen
Publikováno v:
Nature Cancer. 2:1243-1243
Autor:
Dai Fukumura, Rakesh K. Jain, Anna M. Westermark, Alba Luengo, Ahmed Ali, Raphael Ferreira, Keene L. Abbott, Matthew G. Vander Heiden, Véronique Dartois, Kamila Naxerova, Todd R. Golub, Sylvie Roberge, Landry Blanc, Dan G. Duda, Gino B. Ferraro, Jessica M. Possada, Jiang Chen, Ivy X. Chen, Zohreh Amoozgar, Costas A. Lyssiotis, Amy Deik, Clary B. Clish, Shawn M. Davidson, Christopher W. Ng, Xin Jin, Mark Duquette, Christopher R. Chin, Divya Bezwada, Brendan Prideaux, David P. Kodack
Publikováno v:
Cancer Research. 81:90-90
Brain metastases are refractory to therapies that otherwise control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the unique brain microenvironment contributes to this therapy resistance. Nutrie
Autor:
Christopher W. Ng, Pooja Varshney
Publikováno v:
Pediatrics. 144:S54-S55
JK Gerald, JM Fisher, MA Brown. J Allergy Clin Immunol. 2019;143(2):755–764 To evaluate the efficacy of school-supervised administration of once-daily inhaled corticosteroid to improve asthma control and reduce school absences in a primarily low-in