Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christopher W. McAleer"'
Autor:
Michael J. Rupar, Trevor Sasserath, Ethan Smith, Brandon Comiter, Narasimhan Sriram, Christopher J. Long, Christopher W. McAleer, James J. Hickman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenoc
Externí odkaz:
https://doaj.org/article/3eca252d5463404c9ef4578759b51b6e
Autor:
Victoria L. Slaughter, John W. Rumsey, Rachel Boone, Duaa Malik, Yunqing Cai, Narasimhan Narasimhan Sriram, Christopher J. Long, Christopher W. McAleer, Stephen Lambert, Michael L. Shuler, J. J. Hickman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes. We have developed a human-on-a-chip model composed of human hepatocytes and adipose
Externí odkaz:
https://doaj.org/article/3547c91f62364f5898fce5860fb718e0
Autor:
Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti‐LaPatki, Michael L. Shuler, James J. Hickman
Publikováno v:
Advanced Science, Vol 7, Iss 13, Pp n/a-n/a (2020)
Abstract A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum‐free medium is developed. This in vit
Externí odkaz:
https://doaj.org/article/e002bbb5aaeb472b9e127685dc612392
Autor:
Carlota Oleaga, Golareh Jalilvand, Gregg Legters, Candace Martin, Gail Ekman, Christopher W. McAleer, Christopher J. Long, James J. Hickman
Publikováno v:
APL Bioengineering, Vol 3, Iss 3, Pp 036103-036103-8 (2019)
Cardiac ischemic events increase the risk for arrhythmia, heart attack, heart failure, and death and are the leading mortality condition globally. Reperfusion therapy is the first line of treatment for this condition, and although it significantly re
Externí odkaz:
https://doaj.org/article/5f11ce822a804a7e90dd1c8e4fc6d2fa
Publikováno v:
Bioengineering, Vol 7, Iss 4, p 133 (2020)
In vitro generation of functional neuromuscular junctions (NMJs) utilizing the same induced pluripotent stem cell (iPSC) source for muscle and motoneurons would be of great value for disease modeling and tissue engineering. Although, differentiation
Externí odkaz:
https://doaj.org/article/190f58a2b6ce4e87898694fec32fbf62
Autor:
Yunqing Cai, Michael L. Shuler, Narasimhan Narasimhan Sriram, Christopher J. Long, Duaa Malik, Victoria L. Slaughter, Rachel Boone, Christopher W. McAleer, Stephen Lambert, John W. Rumsey, James J. Hickman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes. We have developed a human-on-a-chip model composed of human hepatocytes and adipose tissue c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48e79795bf3b3db7d946cf3ceefe2e9
https://doaj.org/article/3547c91f62364f5898fce5860fb718e0
https://doaj.org/article/3547c91f62364f5898fce5860fb718e0
Autor:
John W. Rumsey, Case Lorance, Max Jackson, Trevor Sasserath, Christopher W. McAleer, Christopher J. Long, Arindom Goswami, Melissa A. Russo, Shruti M. Raja, Karissa L. Gable, Doug Emmett, Lisa D. Hobson‐Webb, Manisha Chopra, James F. Howard, Jeffrey T. Guptill, Michael J. Storek, Miguel Alonso‐Alonso, Nazem Atassi, Sandip Panicker, Graham Parry, Timothy Hammond, James J. Hickman
Publikováno v:
Adv Ther (Weinh)
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here we describe a phenotypic, human-on-a-chip (HoaC) electrical conduction model of two rare autoimmune demyelinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1c1dbc945b9d3fe2e8b4e7d5ec6672
https://europepmc.org/articles/PMC9540753/
https://europepmc.org/articles/PMC9540753/
Autor:
Camilly P. Pires de Mello, Carlos Carmona-Moran, Christopher W. McAleer, Julian Perez, Elizabeth A. Coln, Christopher J. Long, Carlota Oleaga, Anne Riu, Reine Note, Silvia Teissier, Jessica Langer, James J. Hickman
Publikováno v:
Lab Chip
Body-on-a-chip in vitro systems are a promising technology that aims to increase the predictive power of drug efficacy and toxicity in humans when compared to traditional animal models. Here, we developed a new heart-liver body-on-a-chip system with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd99dfc816c65003bd4885bcce6c968
https://doi.org/10.1039/c9lc00861f
https://doi.org/10.1039/c9lc00861f
Autor:
Christopher J. Long, Alexander S.T. Smith, Candace Martin, Yunqing Cai, Christopher W. McAleer, Sarah A. Najjar, James J. Hickman, Balaji Srinivasan, Herman H. Vandenburgh
Publikováno v:
Biotechnol Bioeng
In vitro systems that mimic organ functionality have become increasingly important tools in drug development studies. Systems that measure the functional properties of skeletal muscle are beneficial to compound screening studies and also for integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3372ff95337a14f3dfa7f373def59984
https://doi.org/10.1002/bit.27231
https://doi.org/10.1002/bit.27231
Autor:
Patrick J. Antonelli, Christopher J. Long, Yifei Jin, James J. Hickman, Christopher W. McAleer, Yong Huang, Ruitong Xiong
Publikováno v:
Journal of Manufacturing Science and Engineering. 143
Three-dimensional (3D) extrusion printing of cellular/acellular structures with biocompatible materials has been widely investigated in recent years. However, the requirement of a suitable solidification rate of printable ink materials constrains the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3934493c581782a0de9c6e244fc00fe
https://doi.org/10.1115/1.4051010
https://doi.org/10.1115/1.4051010