Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Christopher W. Loomis"'
Publikováno v:
Anesthesiology. 106:795-805
Background Spinal prostaglandins are important in the early pathogenesis of spinal nerve ligation (SNL)-induced allodynia. This study examined the effect of SNL on the expression of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 receptors in the
Publikováno v:
Anesthesiology. 100:1611-1614
Publikováno v:
Anesthesiology. 99:1180-1188
Background Prostaglandins, synthesized in the spinal cord in response to noxious stimuli, are known to facilitate nociceptive transmission, raising questions about their role in neuropathic pain. The current study tested the hypothesis that spinal ne
Publikováno v:
Pain. 101:139-147
To determine if spinal prostaglandins (PG) contribute to tactile allodynia, male, Sprague-Dawley rats were fitted with either intrathecal (i.t.) microdialysis or drug delivery catheters 3 days before tight ligation of the left lumber 5/6 spinal nerve
Publikováno v:
Pain. 92:351-361
The purpose of this study was to investigate the allodynic effect of bicuculline (BIC) given topically to the dorsal surface of the rat spinal cord, and to determine if spinal prostaglandins (PGs) mediate the allodynic state arising from spinal GABA(
Publikováno v:
Neuroscience Letters. 287:89-92
Distension of the distal esophagus in the anesthetized rat causes a vagally-mediated arterial pressor and tachycardia response. To investigate the nature of viscerosensory fibers in the afferent limb of this reflex, the present study was carried out
Publikováno v:
Anesthesia & Analgesia. 88:1125-1130
UNLABELLED After the administration of intrathecal strychnine, allodynia is manifested as activation of supraspinal sites involved in pain processing and enhancement of cardiovascular responses evoked by normally innocuous stimuli. The objective of t
Publikováno v:
Anesthesiology. 90:165-173
Background Blockade of spinal glycine receptors with intrathecal strychnine produces an allodynia-like state in the anesthetized rat. Innocuous hair deflection in the presence of intrathecal strychnine induces a nociceptive-like activation of catecho
Publikováno v:
Brain Research. 808:106-109
Intrathecal (i.t.) strychnine produces localized allodynia in the rat without peripheral or central nerve injury. Intrathecal CPA (A1-selective agonist) and CGS-21680 (A2-selective agonist) dose-dependently inhibited strychnine-allodynia but with a 5
Publikováno v:
Anesthesiology. 104(2)
Background Spinal prostaglandins seem to be important in the early pathogenesis of experimental neuropathic pain. Here, the authors investigated changes in the expression of cyclooxygenase and nitric oxide synthase (NOS) isoforms in the lumbar, thora