Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher W. Leonard"'
Publikováno v:
RNA. 20:846-854
RNA secondary structure modeling is a challenging problem, and recent successes have raised the standards for accuracy, consistency, and tractability. Large increases in accuracy have been achieved by including data on reactivity toward chemical prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506e90639e836da7db6ac580bc8588ed
https://doi.org/10.1261/rna.043323.113
https://doi.org/10.1261/rna.043323.113
Autor:
Christopher W. Leonard, Kevin M. Weeks, Wayne Huggins, David H. Mathews, Stanislav Bellaousov, Christine E. Hajdin
Publikováno v:
Proceedings of the National Academy of Sciences
A pseudoknot forms in an RNA when nucleotides in a loop pair with a region outside the helices that close the loop. Pseudoknots occur relatively rarely in RNA but are highly overrepresented in functionally critical motifs in large catalytic RNAs, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1476d33b8f76c54f5f51de2de5dddcb1
https://doi.org/10.1073/pnas.1219988110
https://doi.org/10.1073/pnas.1219988110
Autor:
Christopher W. Leonard, Cristina Gherghe, Tania Lombo, Siddhartha A. K. Datta, Kevin M. Weeks, Alan Rein, Julian W. Bess, Robert J. Gorelick
Publikováno v:
Proceedings of the National Academy of Sciences. 107:19248-19253
All retroviral genomic RNAs contain a cis-acting packaging signal by which dimeric genomes are selectively packaged into nascent virions. However, it is not understood how Gag (the viral structural protein) interacts with these signals to package the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91b81823039e0e6b9ce3ef2a1f94595
https://doi.org/10.1073/pnas.1006897107
https://doi.org/10.1073/pnas.1006897107
Publikováno v:
Journal of Virology. 84:898-906
Retroviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5′ ends by noncovalent base pairing and tertiary interactions. Viral maturation involves large-scale morphological changes in viral proteins and in genomic RNA dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7d3b80590e94fcdf218821661ab22f
https://doi.org/10.1128/jvi.01602-09
https://doi.org/10.1128/jvi.01602-09
Publikováno v:
Biochemistry. 45:14955-14964
Many ribonucleoprotein complexes assemble stepwise in distinct cellular compartments, a process that usually involves bidirectional transport of both RNA and proteins between the nucleus and cytoplasm. The biological rationale for such complex transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec4cc6e4cb8cf5006cded138f8ad993
https://doi.org/10.1021/bi060890g
https://doi.org/10.1021/bi060890g
Autor:
Christopher W. Leonard, Antonella Longo, Traci M. Tanaka Hall, Daniel F. Berndt, Joseph M. Krahn, Gurminder S. Bassi, Kevin M. Weeks
Publikováno v:
Nature Structural & Molecular Biology. 12:779-787
LAGLIDADG endonucleases bind across adjacent major grooves via a saddle-shaped surface and catalyze DNA cleavage. Some LAGLIDADG proteins, called maturases, facilitate splicing by group I introns, raising the issue of how a DNA-binding protein and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c329bb5fb0be13ae82b003af682b8cc
https://doi.org/10.1038/nsmb976
https://doi.org/10.1038/nsmb976
Autor:
Kevin M. Weeks, Christopher W. Leonard, Oleg V. Favorov, Christine E. Hajdin, David H. Mathews, Nikolay V. Dokholyan, Fethullah Karabiber
Accurate RNA structure modeling is an important, incompletely solved, challenge. Single-nucleotide resolution SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) yields an experimental measurement of local nucleotide flexibility that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3eb004280ae860ce8374fda048b20e1
Publikováno v:
Journal of the American Chemical Society. 131(7)
The difficulty of analyzing higher order RNA structure, especially for folding intermediates and for RNAs whose functions require domains that are conformationally flexible, emphasizes the need for new approaches for modeling RNA tertiary structure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c6f4d006a1e98e39944429948a5fff
https://pubmed.ncbi.nlm.nih.gov/19193004
https://pubmed.ncbi.nlm.nih.gov/19193004
Autor:
Joseph M Watts, Cristina Gherge, Christopher W. Leonard, Alan Rein, Justin T. Low, Tania Lombo, Robert J. Gorelick, Stefanie A Knoepfel, Julian W. Bess, Siddhartha Ak Datta, Ben Berkhout, Kevin M. Weeks, Olivier ter Brake
Publikováno v:
Retrovirology, Vol 8, Iss Suppl 2, p O1 (2011)
Retrovirology
Retrovirology
Our laboratory is blending new RNA chemistries, largely directed at the ribose 2'-hydroxyl group, with quantitative interpretation to create new kinds of chemical microscopes for accurate RNA structure analysis. This seminar will focus on two example
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5467fdea5155309b09620074588bd5b