Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christopher W. Cowan"'
Autor:
Brandon W. Hughes, Jessica L. Huebschman, Evgeny Tsvetkov, Benjamin M. Siemsen, Kirsten K. Snyder, Rose Marie Akiki, Daniel J. Wood, Rachel D. Penrod, Michael D. Scofield, Stefano Berto, Makoto Taniguchi, Christopher W. Cowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Powerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated contexts and cues activate ensembles of nucleus accumbens (NAc) neurons, including D1-class me
Externí odkaz:
https://doaj.org/article/5eec6fa2690741769ccb04f1ac7279bf
Autor:
Jennifer Y. Cho, Jeffrey A. Rumschlag, Evgeny Tsvetkov, Divya S. Proper, Hainan Lang, Stefano Berto, Ahlem Assali, Christopher W. Cowan
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100289- (2024)
Background: Heterozygous mutations or deletions of MEF2C cause a neurodevelopmental disorder termed MEF2C haploinsufficiency syndrome (MCHS), characterized by autism spectrum disorder and neurological symptoms. In mice, global Mef2c heterozygosity ha
Externí odkaz:
https://doaj.org/article/5800355a599b4900a683921f4bd020f8
Autor:
Jessica A. Cooley Coleman, Sara M. Sarasua, Hannah Warren Moore, Luigi Boccuto, Christopher W. Cowan, Steven A. Skinner, Jane M. DeLuca
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract Introduction MEF2C‐related disorders are characterized by developmental and cognitive delay, limited language and walking, hypotonia, and seizures. A recent systematic review identified 117 patients with MEF2C‐related disorders across 43
Externí odkaz:
https://doaj.org/article/846519327b42404aaec70ebde4ce1f10
Autor:
Benjamin M. Siemsen, Sarah M. Barry, Kelsey M. Vollmer, Lisa M. Green, Ashley G. Brock, Annaka M. Westphal, Raven A. King, Derek M. DeVries, James M. Otis, Christopher W. Cowan, Michael D. Scofield
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
BackgroundPrelimbic cortical projections to the nucleus accumbens core are critical for cue-induced cocaine seeking, but the identity of the accumbens neuron(s) targeted by this projection, and the transient neuroadaptations contributing to relapse w
Externí odkaz:
https://doaj.org/article/b5fc6239108848da9c09372d755b51fc
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 79-80 (2022)
OBJECTIVES/GOALS: The MEF2 family of transcription factors regulate gene expression controlling cell differentiation and synapse development. Mutations or deletions in the MEF2C gene cause a neurodevelopmental disorder that includes symptoms of autis
Externí odkaz:
https://doaj.org/article/957eeb509e1d474d981ab0d041aba014
Autor:
Jasper A. Heinsbroek, Ana-Clara Bobadilla, Eric Dereschewitz, Ahlem Assali, Reda M. Chalhoub, Christopher W. Cowan, Peter W. Kalivas
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 2018-2027.e3 (2020)
Summary: Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic neurons co-express enk
Externí odkaz:
https://doaj.org/article/614fb1e2f694466a9aed2acb0f9eba64
Autor:
Theresa E Bjorness, Ashwinikumar Kulkarni, Volodymyr Rybalchenko, Ayako Suzuki, Catherine Bridges, Adam J Harrington, Christopher W Cowan, Joseph S Takahashi, Genevieve Konopka, Robert W Greene
Publikováno v:
eLife, Vol 9 (2020)
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitu
Externí odkaz:
https://doaj.org/article/1edbd56319244ea8b019e014994d5ab1
Autor:
Monserrat Armenta-Resendiz, Ahlem Assali, Evgeny Tsvetkov, Christopher W. Cowan, Antonieta Lavin
Publikováno v:
Neuropsychopharmacology. 47:1816-1825
Methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many neuropsychiatric disorders that is produced by altered balance of local excitatory and inhibitory synaptic tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd03e0c6fe7705c7fd8773054423a81
https://doi.org/10.1038/s41386-022-01371-9
https://doi.org/10.1038/s41386-022-01371-9
Autor:
Brandon W Hughes, Benjamin M Siemsen, Evgeny Tsvetkov, Stefano Berto, Jaswinder Kumar, Rebecca G Cornbrooks, Rose Marie Akiki, Jennifer Y Cho, Jordan S Carter, Kirsten K Snyder, Ahlem Assali, Michael D Scofield, Christopher W Cowan, Makoto Taniguchi
Publikováno v:
eLife. 12
Chronic stress can produce reward system deficits (i.e., anhedonia) and other common symptoms associated with depressive disorders, as well as neural circuit hypofunction in the medial prefrontal cortex (mPFC). However, the molecular mechanisms by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78edc4584f27deafae6a79908e12f169
https://doi.org/10.7554/elife.75631
https://doi.org/10.7554/elife.75631
Autor:
Ethan M. Anderson, Evgeny Tsvetkov, Allison Galante, Derek DeVries, Lauren M. McCue, Daniel Wood, Sarah Barry, Stefano Berto, Antonieta Lavin, Makoto Taniguchi, Christopher W. Cowan
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Opioid use produces enduring associations between drug reinforcement/euphoria and discreet or diffuse cues in the drug-taking environment. These powerful associations can trigger relapse in individuals recovering from opioid use disorder (OUD). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff3a91f7321a9b60ecad1e11327b80e5
https://doi.org/10.1073/pnas.2210953120
https://doi.org/10.1073/pnas.2210953120