Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Christopher W. Cairo"'
Autor:
Ikhui Kho, Ekaterina P. Demina, Xuefang Pan, Irene Londono, Christopher W. Cairo, Luisa Sturiale, Angelo Palmigiano, Angela Messina, Domenico Garozzo, Roth-Visal Ung, Fabrice Mac-Way, Éric Bonneil, Pierre Thibault, Mathieu Lemaire, Carlos R. Morales, Alexey V. Pshezhetsky
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Sialidosis is an ultra-rare multisystemic lysosomal disease caused by mutations in the neuraminidase 1 (NEU1) gene. The severe type II form of the disease manifests with a prenatal/infantile or juvenile onset, bone abnormalities, severe neuropatholog
Externí odkaz:
https://doaj.org/article/020e7d15b3464b17be3a39d683d06c32
Publikováno v:
Biophysical Reports, Vol 2, Iss 3, Pp 100064- (2022)
The B cell membrane expresses sialic-acid-binding immunoglobulin-like lectins, also called Siglecs, that are important for modulating immune response. Siglecs have interactions with sialoglycoproteins found on the same membrane (cis-ligands) that res
Externí odkaz:
https://doaj.org/article/9a7355720d0a45bfbf39fbffed742d95
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cell migration to a site of inflammation is an important step of the immune response. This process is coordinated by cytokines, receptors, and the signal processing machinery of the cell. Many cellular receptors are glycosylated, and their activity c
Externí odkaz:
https://doaj.org/article/201fb440fbc245c1a05861380baa0ac6
Autor:
Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky, Gregory A. Lodygensky
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities. In thi
Externí odkaz:
https://doaj.org/article/2b900a7c92274714b0c1ed44a9c8c208
Autor:
Ekaterina P. Demina, Victoria Smutova, Xuefang Pan, Anne Fougerat, Tianlin Guo, Chunxia Zou, Radhika Chakraberty, Brendan D. Snarr, Tze C. Shiao, Rene Roy, Alexander N. Orekhov, Taeko Miyagi, Muriel Laffargue, Donald C. Sheppard, Christopher W. Cairo, Alexey V. Pshezhetsky
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background Chronic vascular disease atherosclerosis starts with an uptake of atherogenic modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of arterial fatty streaks and eventually atheromatous plaques. Increas
Externí odkaz:
https://doaj.org/article/e7dc017e27064f1db8d43dacecc291d0
Autor:
Md. Amran Howlader, Caishun Li, Chunxia Zou, Radhika Chakraberty, Njuacha Ebesoh, Christopher W. Cairo
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Within the plasma membrane environment, glycoconjugate-receptor interactions play an important role in the regulation of cell-cell interactions. We have investigated the mechanism and activity of the human neuraminidase (NEU) isoenzyme, NEU3, on T ce
Externí odkaz:
https://doaj.org/article/741557fae43949be9b04d24ab5123453
Autor:
Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 76-88 (2018)
Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NE
Externí odkaz:
https://doaj.org/article/541e8d755b704d37851988c197c97c88
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 10, Pp o1910-o1910 (2008)
The title compound, a bis-5,5′-triazole, C38H28N6O4, was observed as a side-product from the Sharpless–Meldal click reaction of the corresponding coumarin alkyne and benzylazide. Although the compound was present as a minor component, it crystall
Externí odkaz:
https://doaj.org/article/260c7c98e87f43d39b9d9bd75b92adfa
Autor:
Gour Chand Daskhan, Bruce Motyka, Roger Bascom, Hanh Thuc Tran, Kesheng Tao, Lori J. West, Christopher W. Cairo
Publikováno v:
RSC Chemical Biology. 3:1260-1275
A strategy for augmenting multivalent glycoconjugates with a serum-protein recognition element extends half-life in vivo and maintains engagement with lectin receptors.
Autor:
Gour Chand, Daskhan, Bruce, Motyka, Roger, Bascom, Hanh Thuc, Tran, Kesheng, Tao, Lori J, West, Christopher W, Cairo
Publikováno v:
RSC chemical biology. 3(10)
Synthetic glycoconjugates are used in the development of vaccines and the design of inhibitors for glycan-protein interactions. The