In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS

Autor: Christopher W. Armstrong, Fane F. K. Mensah, Maria J. Leandro, Venkat Reddy, Paul R. Gooley, Saul Berkovitz, Geraldine Cambridge

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

IntroductionDisturbances of energy metabolism contribute to the clinical manifestations of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Previously, we found that B cells from ME/CFS patients have an increased expression of CD24, a mod

Externí odkaz: https://doaj.org/article/16803fdcd8cc4367b8b7695459a54a96

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Autor: Fane F. K. Mensah, Christopher W. Armstrong, Venkat Reddy, Amolak S. Bansal, Saul Berkovitz, Maria J. Leandro, Geraldine Cambridge

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

CD24 expression on pro-B cells plays a role in B cell selection and development in the bone marrow. We previously detected higher CD24 expression and frequency within IgD+ naïve and memory B cells in patients with Myalgic Encephalomyelitis/Chronic F

Externí odkaz: https://doaj.org/article/523d65fc6c384c538cba7f0fd9d966b0

Supplementary Figure from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers

Autor: David J.J. Waugh, Melissa J. LaBonte, Elena Deryugina, Johann S. de Bono, Amina Zoubeidi, James P. Quigley, Daniel B. Longley, Ian G. Mills, Jenny Worthington, Chee Wee Ong, Judith M. Manley, Christopher W. Armstrong, Melanie McKechnie, Pamela J. Maxwell

Supplementary Figure from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acdbbebf695349350865cf6c1f988b4
https://doi.org/10.1158/1541-7786.22527356.v1

Attenuating adaptive VEGF-A and IL-8 signaling restores durable tumor control in AR-antagonist-treated prostate cancers

Autor: Pamela J. Maxwell, Melanie McKechnie, Christopher W. Armstrong, Judith M. Manley, Chee Wee Ong, Jenny Worthington, Ian G. Mills, Daniel B. Longley, James P. Quigley, Amina Zoubeidi, Johann S. de Bono, Elena Deryugina, Melissa J. LaBonte, David J.J. Waugh

Publikováno v: Maxwell, P J, McKechnie, M, Armstrong, C W, Manley, J M, Ong, C W, Worthington, J, Mills, I G, Longley, D B, Quigley, J P, Zoubedi, A, de Bono, J S, Deryugina, E, LaBonte, M J & Waugh, D J J 2022, ' Attenuating adaptive VEGF-A and IL-8 signaling restores durable tumor control in AR-antagonist-treated prostate cancers ', Molecular cancer research : MCR, vol. 20, no. 6, pp. 841-853 . https://doi.org/10.1158/1541-7786.MCR-21-0780

Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468ed4960b88d78fad4a8d43671eabc
https://pure.qub.ac.uk/en/publications/1f1e4109-ccbc-4e72-81f3-68853787d542

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases

Autor: Donald P. Lewis, Paul R. Gooley, Christopher W. Armstrong, Neil R. McGregor

Publikováno v: Diagnostics
Volume 9
Issue 3
Diagnostics, Vol 9, Iss 3, p 70 (2019)

Post-exertional malaise (PEM) is a cardinal predictive symptom in the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). If the cases overexert themselves they have what is termed &ldquo
payback&rdquo
resulting in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe6fe965a1fecb26db4f5284a7bef23