Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Christopher W Peterson"'
Autor:
E Fabian Cardozo-Ojeda, Elizabeth R Duke, Christopher W Peterson, Daniel B Reeves, Bryan T Mayer, Hans-Peter Kiem, Joshua T Schiffer
Publikováno v:
eLife, Vol 10 (2021)
Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To projec
Externí odkaz:
https://doaj.org/article/e4fa43b65ac8466fba011375655a9c96
Autor:
Christopher W Peterson, Jianbin Wang, Claire Deleage, Sowmya Reddy, Jasbir Kaur, Patricia Polacino, Andreas Reik, Meei-Li Huang, Keith R Jerome, Shiu-Lok Hu, Michael C Holmes, Jacob D Estes, Hans-Peter Kiem
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006956 (2018)
Autologous transplantation and engraftment of HIV-resistant cells in sufficient numbers should recapitulate the functional cure of the Berlin Patient, with applicability to a greater number of infected individuals and with a superior safety profile.
Externí odkaz:
https://doaj.org/article/1c2b7e7be53d42f1b7be0b885f75a1b1
Autor:
Anjie Zhen, Christopher W Peterson, Mayra A Carrillo, Sowmya Somashekar Reddy, Cindy S Youn, Brianna B Lam, Nelson Y Chang, Heather A Martin, Jonathan W Rick, Jennifer Kim, Nick C Neel, Valerie K Rezek, Masakazu Kamata, Irvin S Y Chen, Jerome A Zack, Hans-Peter Kiem, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006891 (2018)
[This corrects the article DOI: 10.1371/journal.ppat.1006753.].
Externí odkaz:
https://doaj.org/article/e5944840550840ada1cfc5ed1d1077e8
Autor:
Anjie Zhen, Christopher W Peterson, Mayra A Carrillo, Sowmya Somashekar Reddy, Cindy S Youn, Brianna B Lam, Nelson Y Chang, Heather A Martin, Jonathan W Rick, Jennifer Kim, Nick C Neel, Valerie K Rezek, Masakazu Kamata, Irvin S Y Chen, Jerome A Zack, Hans-Peter Kiem, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006753 (2017)
Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products c
Externí odkaz:
https://doaj.org/article/a334eb1814b543559bacff9a9e54a647
Autor:
Julia Ling-Yu Chen, Daniel Merl, Christopher W Peterson, Jianli Wu, Patrick Yantyng Liu, Hanwei Yin, Deborah M Muoio, Don E Ayer, Mike West, Jen-Tsan Chi
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001093 (2010)
Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast ca
Externí odkaz:
https://doaj.org/article/63b1b63381834dcca4325d2a5db10c33
Autor:
Jason Murray, Teresa Einhaus, Rasika Venkataraman, Stefan Radtke, Anjie Zhen, Mayra A. Carrillo, Scott G. Kitchen, Christopher W. Peterson, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 276-287 (2023)
Hematopoietic stem cell gene therapy has been successfully used for a number of genetic diseases and is also being explored for HIV. However, toxicity of the conditioning regimens has been a major concern. Here we compared current conditioning approa
Externí odkaz:
https://doaj.org/article/3a1ba5b791194c6d9f5f185577ce78a5
Autor:
Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, James I. Mullins, Hans-Peter Kiem, Deborah Heydenburg Fuller, Christopher W. Peterson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which facilitates viral escap
Externí odkaz:
https://doaj.org/article/23b8184a8d714211a8e14e49ff22762b
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The development of higher-order topological insulators enables robust localization of energy at lower-dimensional boundaries. Here the authors demonstrate that partial dislocation in higher order topological insulators can be intuitively understood a
Externí odkaz:
https://doaj.org/article/e6f702ceb26c448e9ae407bb88d1c623
Autor:
Daniel Stone, Nadja Meumann, Anne-Sophie Kuhlmann, Christopher W. Peterson, Hong Xie, Pavitra Roychoudhury, Michelle A. Loprieno, Xuan-Khang Vu, Daniel E. Strongin, Elizabeth J. Kenkel, Anoria Haick, Laurence Stensland, Willimark M. Obenza, Jacob Parrott, Veronica Nelson, Robert D. Murnane, Meei-Li Huang, Martine Aubert, Hans-Peter Kiem, Hildegard Büning, Keith R. Jerome
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0009-e0009 (2023)
Background and Aims:. Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have
Externí odkaz:
https://doaj.org/article/1d40d622a45b4cc6aa011947303c4dea
Autor:
Françoise Haeseleer, Yoshinori Fukazawa, Haesun Park, Benjamin Varco-Merth, Blake J. Rust, Jeremy V. Smedley, Karsten Eichholz, Christopher W. Peterson, Rosemarie Mason, Hans-Peter Kiem, Mario Roederer, Louis J. Picker, Afam A. Okoye, Lawrence Corey
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 304-319 (2021)
Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate th
Externí odkaz:
https://doaj.org/article/2e4204042ab849e8adedcd5d6bbb820e